Widiyana, Devi (2013) Pengaruh Pemberian Ekstrak Air Buah Kesemek (Diospyros kaki L.f.) terhadap Kadar Malondialdehid (MDA) dan Gambaran Histopatologi Jaringan Sendi Tikus (Rattus novergicus) Artritis. Sarjana thesis, Universitas Brawijaya.
Abstract
Artritis reumatoid (AR) merupakan penyakit inflamasi kronik pada persendian. Pengobatan AR seperti pemberian Nonsteroidal Anti-Inflammatory Drugs (NSID) memiliki efek samping seperti pendarahan pada gastrointestinal. Buah kesemek memiliki kandungan bahan sebagai antioksidan dan antiinflamasi. Tujuan penelitian ini adalah untuk mengetahui potensi pemberian ekstrak air buah kesemek terhadap penurunan kadar malondialdehid (MDA) dan perbaikan gambaran histopatologi jaringan sendi tikus artritis hasil induksi Complete Freund’s Adjuvan (CFA). Penelitian ini mengunakan hewan coba tikus yang dikelompokan menjadi 4 kelompok yaitu kelompok kontrol, kelompok artritis, kelompok artritis yang mendapat terapi 750 mg/Kg BB dan kelompok artritis yang mendapat terapi 1000 mg/Kg BB. Hasil penelitian menunjukan bahwa terapi ekstrak air buah kesemek dapat menurunkan kadar malondialdehid (MDA). Dosis terapi 1000 mg/Kg BB menunjukan dosis efektif menurunkan kadar MDA. Terdapat perbaikan gambaran histopatologi jaringan sendi tikus artritis yang mendapat terapi ekstrak air buah kesemek.
English Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints. Treatments such as Nonsteroidal AntiInflammatory Drugs (NSID) has side effects such as gastrointestinal bleeding. Persimmon contains antioxidant and antiinflammatory. The aim of this study was to determine the potential of water extract of persimmon to decreased the levels of malondialdehyde (MDA) and repaired joint tissue histopathology of arthritis rats induced by Complete Freunds Adjuvant (CFA). This study used rats were divided into 4 groups, the control group, arthritis group, group that received therapy for arthritis 750 mg/kg of body weight and group that received therapy for arthritis 1000 mg/Kg of body weight. The results showed that the water extract of persimmon therapy can reduced levels of MDA. Therapeutic dose of 1000 mg/kg of body weight is affective dose to reduced levels of MDA. There is showed joint tissue histopathology of arthritis rat were repaired treat with water extract of persimmon.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2013/1/051307300 |
| Subjects: | 600 Technology (Applied sciences) > 636 Animal husbandry > 636.08 Specific topics in animal husbandry > 636.089 Veterinary medicine |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Hasbi |
| Date Deposited: | 20 Aug 2013 14:37 |
| Last Modified: | 19 Oct 2021 04:17 |
| URI: | http://repository.ub.ac.id/id/eprint/126860 |
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