Widyani, ElsaLarissa (2016) Pengaruh Paparan Subkronik Debu Vulkanik Terhadap Kadar SGOT Dan SGPT Tikus Strain Wistar. Sarjana thesis, Universitas Brawijaya.
Abstract
Debu vulkanik merupakan partikel berukuran kecil yang diciptakan selama erupsi vulkanik. Kandungan terbanyak yang terdapat pada debu vulkanik adalah Silika yang merupakan radikal bebas yang apabila terinhalasi dan beredar di pembuluh darah dan sampai ke sel hepar dapat berefek pada kerusakan sel hepar akibat ketidak seimbangan radikal bebas dengan antioksidan. Kerusakan sel hepar mengakibatkan pengeluaran enzim dalam sel hepar yaitu SGOT dan SGPT. Tujuan dari penelitian ini adalah menganalisis adanya perubahan kadar SGOT dan SGPT pada tikus jantan normal strain Wistar yang terpapar debu vulkanik secara subkronik (28 hari). Studi eksperimen murni menggunakan Post Test Only Control Group Design dilakukan terhadap hewan coba tikus Wistar jantan dengan memaparkan debu vulkanik dosis 6,25 mg/m3 (VA), 12,5 mg/m3 (VB), dan 25 mg/m3 (VC) selama 1 jam/hari dan kelompok kontrol yang tak dipapar debu vulkanik (N). Variabel yang diukur adalah SGOT dan SGPT. Analisa data menggunakan uji One Way ANOVA. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna pada kadar SGOT (p=0,6) dan SGPT (p=0,48). Kesimpulan dari penelitian ini adalah tidak terdapat perbedaan kadar SGOT dan SGPT pada tikus jantan normal strain Wistar yang terpapar debu vulkanik secara sub kronik (28 hari).
English Abstract
Volcanic dusts are small sized particles that created during volcanic eruptions. Volcanic dusts mostly made of Silica, which is free radical that if inhaled and circulated in the bloodstream and to the liver can cause hepatocellular damage as a result of imbalance between free radicals and antioxidants. Hepatocytes then released AST and ALT enzymes as a result of hepatocellular damage. The purpose of this study was to analyze the changes in levels of SGOT / SGPT of male Wistar rats that were exposed to volcanic ash in sub chronic periods (28 days). True experimental studies using Post Test Only Control Group Design conducted on male Wistar rats by exposing the volcanic dust at dose 6.25 mg/m3 (VA), 12.5 mg/m3 (VB), and 25 mg/m3 (VC) for 1 hour / day and the control group that not exposed to volcanic ash (N). The variables measured were AST and ALT. One Way ANOVA used to analyze the data. The results showed there were no significant differences in the levels of AST (p=0,6) and ALT (p=0,8). From the study, it can be concluded that there are no differences in the levels of AST and ALT in normal male Wistar Rats strain that were exposed to volcanic ash in sub-chronic (28 days) periods.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/830/051702707 |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Kustati |
| Date Deposited: | 20 Mar 2017 10:54 |
| Last Modified: | 19 Oct 2021 06:11 |
| URI: | http://repository.ub.ac.id/id/eprint/126549 |
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