Pranidya, NadaPutri (2016) Hubungan Antara Kadar Laktat Dengan Derajat Keparahan Sepsis pada Sepsis Neonatorum. Sarjana thesis, Universitas Brawijaya.
Abstract
Sepsis neonatorum masih menjadi penyebab utama tingginya angka kematian bayi di Indonesia. Gejala awal yang tidak spesifik menyebabkan sepsis seringkali sulit didiagnosa sehingga banyak yang memiliki outcome buruk, karena keterlambatan penanganan akan mengakibatkan kematian. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar laktat dengan derajat keparahan sepsis dan nilai prognostik kadar laktat. Penelitian ini menggunakan uji korelasi dan uji prognostik. Dari 30 subyek didapatkan 4 subyek SIRS, 7 subyek sepsis, 9 subyek sepsis berat, dan 10 subyek MODS (Multi Organ Dysfunction Syndrome). Hasil uji korelasi diperoleh adanya hubungan positif dan bermakna (p=0,023) antara kadar laktat dengan derajat keparahan sepsis sebesar 41,4% dimana setiap kenaikan satu derajat sepsis tejadi peningkatan kadar laktat sebesar 0,151 mmol/L. Hasil uji prognostik kadar laktat untuk menentukan outcome subyek dengan cut off ≥ 2,5 mmol/L menunjukkan sensitivitas 66,7% dan spesifisitas 76,2%. Uji chi square kadar laktat > 2 mmol/L dan < 2 mmol/L tidak didapat perbedaan yang bermakna antara keduanya pada outcome pasien. OR = 1,3 menunjukkan bahwa meskipun tidak ada perbedaan yang bermakna namun outcome meninggal lebih besar 1,3 kali dibanding outcome hidup pada kadar laktat > 2 mmol/L. Hasil uji pada kadar laktat > 5 mmol/L dan < 5 mmol/L tidak didapat perbedaan yang bermakna antara keduanya pada outcome pasien. OR = 4,8 menunjukkan bahwa meskipun tidak ada perbedaan yang bermakna namun outcome meninggal lebih besar 4,8 kali dibandingkan dengan outcome hidup pada kadar laktat > 5 mmol/L. Sehingga kadar laktat > 5 mmol/L lebih dapat menentukan outcome meninggal pada pasien sepsis neonatorum.
English Abstract
Neonatal sepsis remains a major cause of high infant mortality rate in Indonesia. The intial symptoms are not specific which caused difficulty in diagnosing sepsis due to any delays in treatment will lead to death. This study is to determine the relationship between lactate levels and severity of sepsis degree and lactate prognostic value. This study uses correlation and prognostic test conducted by taking secondary data. From 30 subjects obtained 4 SIRS, 7 sepsis, 9 severe sepsis, and 10 MODS. Positive correlation test 17.1% occured between lactate levels and severity of sepsis degree, lactate is increasing 0.151 mmol/L in each degree. Lactate levels’ prognostic value to determine outcome with a cut-off ≥2.5 mmol/L result in 66.7% of sensitivity and 76.2% of specificity. It is concluded that lactate levels with a cut-off ≥2.5 mmol/L is specific but not sensitive for determining the outcome. Chi-square test’ lactate levels >2 mmol/L and <2 mmol/L shows no significant differences on patient outcomes. OR = 1.3 shows that even though there’s no significant difference in outcome but death is 1.3 times greater than live in lactate levels >2 mmol/L. In lactate levels >5 mmol/L and <5 mmol/L obtained no significant differences on patient outcomes. OR = 4.8 shows that even though there’s no significant difference in outcome but death is 4.8 times greater life in lactate levels >5 mmol/L. So that the lactate levels >5 mmol/L is more able to determine outcomes of death in patients with neonatal sepsis.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/742/051700264 |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Kustati |
| Date Deposited: | 18 Jan 2017 15:03 |
| Last Modified: | 19 Oct 2021 03:31 |
| URI: | http://repository.ub.ac.id/id/eprint/126451 |
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