Maulida, KhairaHanifah (2016) Pengaruh Ekstrak Daun Kemiri (Aleurites Moluccana) Terhadap Kadar Trigliserida Serum Tikus (Rattus Norvegicus) Wistar Model Diabetes Mellitus Tipe 2. Sarjana thesis, Universitas Brawijaya.
Abstract
Peningkatan kadar trigliserida merupakan masalah penyerta yang sering terjadi pada penderita Diabetes mellitus tipe 2. Penggunaan bermacam-macam obat untuk menurunkan kadar trigliserida pada penderita Diabetes mellitus ini, kerap kali menimbulkan bermacam-macam efek samping. Oleh karena itu, perlu dilakukan penelitian untuk menemukan obat herbal yang dapat digunakan dalam terapi penurunan kadar Trigliserida pada penderita Diabetes mellitus. Daun kemiri mengandung flavonoid swertisin yang diduga dapat menghambat enzim α-glukosidase yang berperan pada metabolism karbohidrat. Penelitian ini bertujuan untuk membuktikan bahwa ekstrak daun kemiri (Aleurites moloccana) dapat menurunkan kadar trigliserida serum tikus (Rattus Norvegicus) wistar model diabetes mellitus tipe 2. Metode penelitian yang digunakan adalah Randomized Post Test Only Control Group Design. Pemilihan sampel dilakukan dengan cara Simple Random Sampling untuk dibagi dalam 5 kelompok, yaitu kelompok “kontrol negative” (n=4), kelompok “kontrol positif” (n=4), “kelompok perlakuan” D1 (n=4), “kelompok perlakuan” D2 (n=4),dan “kelompok perlakuan” D3 (n=4). Variabel yang diukur adalah kadar trigliserida serum tikus wistar menggunakan uji spektrofotometri. Hasil penelitian menunjukkan adanya perbedaan kadar trigliserida serum tikus wistar yang signifikan antar kelompok perlakuan (Anova, p = 0.000). Terdapat hubungan yang kuat antara penambahan dosis ekstrak daun kemiri dengan penurunan kadar trigliserida serum (pearson correlation, p = 0.001). Pemberian ekstrak daun kemiri cukup berkontribusi terhadap penurunan kadar trigliserida serum tikus wistar. (R2 = 0.584). Kesimpulan dari penelitian ini adalah pemberian ekstrak daun kemiri (Aleurites moluccana) dapat menurunkan kadar trigliserida serum tikus (Rattus Norvegicus) wistar model diabetes mellitus tipe 2.
English Abstract
Elevation of triglycerides levels often occur as a problem accompanying patients with diabetes mellitus type 2. The use of various medications to lower triglyceride levels in patients with diabetes mellitus, often followed by many side effects. For that reason we need to do research to find herbal medication that can be used in the treatment of decreasing levels of triglycerides in patients with diabetes mellitus. Candlenut leaf contain swertisin flavonoids that can inhibit α-glucosidase enzyme that plays a role in the metabolism of carbohydrates. This research was aimed to prove that Candlenut (Aleurites moloccana) leaf extract can reduce Triglyceride Serum levels of Type 2 Diabetes Mellitus Wistar (Rattus norvegicus) Rats Model. The method that used in this research was Randomized Post Test Only Control Group Design. The sample selection was done by Simple Random Sampling to be divided into five groups, that was the "negative control" (n = 4), the "positive control" (n = 4), "treatment group” D1 (n = 4), " treatment group” D2 (n = 4), and the" treatment group” D3 (n = 4). The variables measured was triglyceride serum levels of Wistar rats that was measured by using spectrophotometric test. The results showed that there was a significant differences in triglyceride serum levels of Wistar rats among the groups (ANOVA, p = 0.000). There was a strong relationship between increasing doses of candlenut leaf extract and the reduction in serum triglyceride levels (Pearson correlation, p = 0.001). Candlenut leaf extract was contribute enough to a decrease in serum triglyceride levels Wistar rats. (R2 = 0584). The conclusion of this research is the use of Candlenut (Aleurites moloccana) leaf extract can reduce Triglyceride Serum levels of Type 2 Diabetes Mellitus Wistar (Rattus norvegicus) Rat Model.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/648/051612228 |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Kustati |
| Date Deposited: | 29 Nov 2016 10:35 |
| Last Modified: | 19 Oct 2021 03:30 |
| URI: | http://repository.ub.ac.id/id/eprint/126365 |
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