Farahdina (2016) Pengaruh Paparan Subkronik Debu Vulkanik Gunung Kelud Terhadap Kadar Sgot Dan Sgpt Pada Tikus Model Diabetes Melitus. Sarjana thesis, Universitas Brawijaya.
Abstract
Debu vulkanik adalah partikel batuan vulkanik terfragmentasi yang dapat terinhalasi dan menyebabkan masalah kesehatan melalui peningkatan stres oksidatif, inflamasi sistemik, dan disfungsi endotel. Stres oksidatif maupun inflamasi sistemik tersebut dapat mencapai hepar dan menginduksi sel kupffer mengeluarkan sitokin pro-inflamasi yang mengakibatkan kerusakan hepar. SGOT dan SGPT serum merupakan indikator yang sensitif untuk kerusakan hepar. Penelitian ini bertujuan untuk mengetahui pengaruh paparan subkronik debu vulkanik terhadap kadar SGOT dan SGPT pada penyakit metabolik yang banyak diderita yaitu Diabetes Melitus. Penelitian ini merupakan studi eksperimental murni menggunakan rancangan Post Test Only Control Group Design yang dilakukan terhadap hewan coba tikus Wistar jantan. Sampel dipilih secara random, dibagi dalam lima kelompok, yaitu kelompok Normal(N), Diabetes Melitus(D), Dosis 1(DVA), Dosis 2(DVB) dan Dosis 3(DVC) yang masing-masing kelompok terdapat 4 sampel. Hasil penelitian menunjukkan bahwa terdapat perbedaan bermakna kadar SGOT serum darah antar kelompok dengan nilai p= 0,023 (p < 0,05) (Uji One-Way Anova). Sedangkan, pada hasil pengujian kadar SGPT serum didapatkan nilai p = 0, 248 (p > 0,05) (Uji One-Way Anova), yang menunjukkan bahwa tidak terdapat perbedaan kadar SGPT serum darah antar kelompok. Kesimpulan dari penelitian ini adalah paparan subkronik debu vulkanik mempengaruhi kadar SGOT dan SGPT serum, yang secara statistik mempengaruhi kadar SGOT serum secara signifikan dan mempengaruhi kadar SGPT serum secara tidak signifikan.
English Abstract
Volcanic ash is fragmented particle of volcanic rock that can be inhaled and cause health problems through increased oxidative stress, systemic inflammation, and endothelial dysfunction. Oxidative stress and systemic inflammation can reach the liver and induces kupffer cells to produce pro-inflammatory cytokines that lead to liver damage. SGOT and SGPT serum are sensitive indicators for liver damage. This research is aimed to determine the effect of subchronic volcanic ash exposure against the level of SGOT and SGPT in the metabolic disease that affects many, namely diabetes mellitus. Experimental study using “Post Test Only Control Group Design” was conducted into male rats. Samples were selected by random sampling and divided into five groups, namely Normal(N), diabetes mellitus(D), dosage 1 (DVA), dosage 2 (DVB), and dosage 3 (DVC), each group contained 4 samples. The results showed that there were significant differences in blood serum SGOT levels between groups with p value = 0.023 (p <0.05) (One-Way ANOVA test). Meanwhile, the results of serum SGPT levels p value = 0, 248 (p> 0.05) (One-Way ANOVA test), and showed that there were no differences in the blood serum SGPT levels between groups. The conclusion of this study is the subchronic exposure of volcanic ash affect serum SGOT and SGPT levels, which is statistically, affect significantly serum SGOT and affect insignificantly SGPT levels serum.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/573/ 051610617 |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Kustati |
| Date Deposited: | 20 Oct 2016 08:04 |
| Last Modified: | 20 Oct 2016 08:04 |
| URI: | http://repository.ub.ac.id/id/eprint/126281 |
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