Susilaningtyas, WydhaSeptia (2016) Analisis Cost-Effectiveness Penggunaan Sefotaksim, Seftriakson, Dan Levofloksasin Pada Pasien Demam Tifoid Dengan Status Pembayaran Umum Dan Jaminan Kesehatan Nasional (Penelitian Dilakukan Di Ruma. Sarjana thesis, Universitas Brawijaya.
Abstract
Demam tifoid merupakan penyakit yang disebabkan bakteri Salmonella typhi. Tingginya kasus Multi-Drug Resistance (MDR) Salmonella typhi menyebabkan ketepatan pemilihan antibiotik menjadi kunci utamanya. Penelitian bertujuan menganalisis efektivitas terapi dan efisiensi biaya penggunaan sefotaksim, seftriakson, dan levofloksasin menggunakan Cost-Effectiveness Analysis (CEA) pada pasien demam tifoid dengan status pembayaran umum dan Jaminan Kesehatan Nasional (JKN) berdasarkan perspektif penyedia layanan kesehatan. Penelitian menggunakan data rekam medis dan keuangan pasien secara retrospektif. Sampel dipilih menggunakan teknik total sampling dan diperoleh 25 sampel. Biaya yang dianalisa meliputi biaya antibiotik, rawat inap, laboratorium, dan tindakan tenaga medis. Metode analisis CEA menggunakan perhitungan Average Cost-Effectiveness Ratio (ACER) dan Incremental Cost-Effectiveness Ratio (ICER). Lama rawat inap dan hilangnya demam yang lebih cepat pada pasien anak adalah sefotaksim paten pasien umum (4,2; 2,3 hari) dan sefotaksim generik pasien JKN (4,5; 2,5 hari). Pada pasien dewasa, didapatkan sefotaksim generik pasien umum (5,3; 3,4 hari) dan seftriakson generik pasien JKN (5; 3 hari). Berdasarkan perhitungan ACER dan ICER pasien anak, sefotaksim generik pasien umum lebih cost-effective berdasarkan lama hilangnya demam dengan tambahan biaya Rp 5.110 pada sefotaksim paten pasien umum dan Rp 3.126 pada sefotaksim generik pasien JKN untuk menghasilkan pengurangan 1 hari rawat inap. Pada pasien dewasa, terapi yang lebih cost-effective berdasarkan lama rawat inap dan hilangnya demam adalah sefotaksim generik pasien umum, seftriakson generik pasien JKN, dan tambahan biaya Rp 906 pada levofloksasin generik untuk menghasilkan pengurangan 1 hari rawat inap. Sehingga dapat disimpulkan antibiotik yang lebih cost-effective pada pasien anak dan dewasa adalah sefotaksim generik pasien umum.
English Abstract
Typhoid Fever is a disease caused by bacterium Salmonella typhi. The high incidence of Multi-Drug Resistance (MDR) Salmonella typhi leads to the importance of appropriate antibiotics. This research aimed to analyze the effectiveness of therapy and cost efficiency in the usage of cefotaxime, ceftriaxone, and levofloxacin by using Cost-Effectiveness Analysis (CEA) in typhoid fever patients with general and national health assurance (JKN) payment status viewed from the perspective of health care providers. This research used patient’s medical record and financial data retrospectively. This research had 25 samples that was selected using total sampling. Cost that have been analyzed were antibiotic’s cost, hospitalization’s cost, laboratory’s cost, and medical action’s cost. Pharmacoeconomic analysis method of this research was CEA with the calculation of the Average Cost-Effectiveness Ratio (ACER) and Incremental Cost-Effectiveness Ratio (ICER). Antibiotics which had shorter on the length of stay and the loss of fever in pediatric patients were patent cefotaxime in general patients (4.2; 2.3 days) and generic cefotaxime in JKN patients (4.5; 2.5 days). While in adult patients, generic cefotaxime in general patients (5.3; 3.4 days) and generic ceftriaxone in JKN patients (5; 3 days) had shorter on the length of stay and the loss of fever. Based on the calculation of ACER and ICER in pediatric patients, the payment of generic cefotaxime on general patients was more cost-effective in terms of the fever-free time, whereas in terms of long hospitalization in patients with general payment status using patent cefotaxime required Rp 5,110 as an additional cost and use of generic cefotaxime in patients with JKN payment status required Rp 3,126 per day as an additional cost for reduction in hospitalization. The more cost-effective antibiotic therapy in adult patients based on fever free-time and long hospitalization were generic cefotaxime in general patients; generic ceftriaxone in JKN patients; and generic ceftriaxone in JKN patients in terms of fever-free time with an additional cost of Rp 906 per day for reduction in hospitalization. It can be concluded that the more cost-effective antibiotics in pediatric and adult patients is generic cefotaxime in general patients.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/496/ 051607392 |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Kustati |
| Date Deposited: | 29 Aug 2016 14:12 |
| Last Modified: | 29 Aug 2016 14:12 |
| URI: | http://repository.ub.ac.id/id/eprint/126195 |
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