A`ini, NovitaQurrota (2016) Efek Paparan Subkronis Peptida Polisakarida (Psp) Ganoderma Lucidum Terhadap Kadar Ureum Dan Kreatinin Rattus Novergicus Strain Wistar. Sarjana thesis, Universitas Brawijaya.
Abstract
Saat ini, obat tradisional yang banyak dikonsumsi berasal dari jamur. Masyarakat banyak menggunakan jamur sebagai suplemen makanan untuk pemeliharaan kesehatan. Beberapa jamur telah diisolasi dan diidentifikasi, salah satu contoh adalah Ganoderma lucidum yakni jamur yang telah banyak digunakan untuk pencegahan dan pengobatan berbagai penyakit di negara-negara Asia. Studi true experimental ini bertujuan untuk mengetahui efek paparan subkronik PsP Ganoderma lucidum terhadap kadar ureum dan kreatinin tikus Rattus Novergicus strain wistar. Sebayak 80 tikus wistar jantan dan betina yang berusia 2-3 bulan dengan berat badan 200-300 gram, terbagi dalam empat kelompok perlakuan yaitu kelompok kontrol, kelompok pemberian dosis PsP Ganoderma lucidum 300 mg/kgBB, 600 mg/kgBB, dan 1200 mg/kg selama 90 hari. Dilakukan pengukuran parameter kadar ureum dengan metode Enzymatic UV test Urease - GLDH dan kreatinin dengan metode kinetic test without deproteinisation Jaffe. Dari hasil penelitian, kadar ureum tertinggi ditemukan pada kelompok betina perlakuan PsP dosis 300 mg/kgBB/hr dengan kadar rata-rata ureum sebesar 33.2 mg/dL, sedangkan kadar kreatinin pada perlakuan PsP dosis 1200mg/kgBB/hr, 600mg/kgBB/hr, dan 300mg/kgBB/hr adalah sama besar yakni 0.3 mg/dL. Hasil Anova Test menunjukkan tidak ada perbedaan signifikan pada semua dosis PsP Ganoderma lucidum . Disimpulkan pemberian PsP Ganoderma lucidum pada 3 variasi dosis tidak berpengaruh signifikan pada kadar ureum dan kreatinin.
English Abstract
Currently, traditional medicine that is widely consumed is derived from mushrooms. Many people use mushrooms as a food supplement for health maintenance. Some mushroom have been isolated and identified. One example is Ganoderma lucidum, a fungus that has been widely used for the prevention and treatment of various diseases in the Asia countries. This true experimental study aims to determine the subchronic exposure effect of PsP Ganoderma lucidum of urea and creatinine level of Rattus novergicus Wistar strain. 80 male and female wistar rats aged 2-3 months weighing 200-300 grams, divided into four treatment groups: control group, a group of dosing PSP Ganoderma lucidum300 mg / kg, 600 mg / kg, and 1200 mg / kg for 90 days. Urea parameter measurements with UV test Enzymatic methods Urease - GLDH and creatinine by kinetic test method without deproteinisation Jaffe. From the research, urea levels are highest in the group of females treated PSP dose of 300 mg / kg / hr to the average level of urea amounted to 33.2 mg / dL, whereas creatinine levels in the treatment of PSP dose of 1200mg / kg / hr, 600 mg / kg / hr , and 300mg / kg / hr is equally large: 0.3 mg / dL. Anova Test results showed no significant difference at all doses PsP Ganoderma lucidum. It is concluded that administration of PsP Ganoderma lucidum at 3 dose variations does not significally influence the level of urea and creatinine.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2016/40/ 051602459 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Kustati |
| Date Deposited: | 31 Mar 2016 14:59 |
| Last Modified: | 31 Mar 2016 14:59 |
| URI: | http://repository.ub.ac.id/id/eprint/126090 |
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