Achmad (2015) Pengaruh Pemberian Susu Kedelai Dalam Menghambat Ketebalan Dinding Pembuluh Darah Aorta Pada Tikus Putih (Rattus Norvegicus Strain Wistar) Dengan Diet Tinggi Lemak. Sarjana thesis, Universitas Brawijaya.
Abstract
Aterosklerosis merupakan penyakit kronik yang kompleks akibat adanya penumpukan lemak pada dinding pembuluh darah. Penumpukan total kolesterol dan LDL dalam jangka waktu lama dapat membentuk plak sehingga dapat meningkatkan ketebalan dinding pembuluh darah. Flavonoid, isoflavon, vitamin C dan vitamin E yang terkandung dalam susu kedelai berperan dalam menghambat oksidasi lemak terutama untuk menghambat oksidasi kolesterol LDL dalam darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kedelai dalam menghambat ketebalan dinding pembuluh darah aorta pada tikus putih (Rattus norvegicus strain wistar) dengan diet tinggi lemak. Penelitian true Experimental Laboratoric dengan metode Control Group Test Design ini menggunakan sampel tikus putih yang dipelihara di Laboratorium Faal FKUB. Penelitian sampel dilakukan menggunakan metode rancangan acak lengkap dengan jumlah sampel total sebanyak 25 tikus putih. Hasil analisis statistik menggunakan One Way ANOVA tidak menunjukkan adanya perbedaan yang signifikan antar kelompok, namun hasil analisis deskriptif menunjukkan kecenderungan adanya penurunan ketebalan dinding pembuluh darah aorta dengan meningkatnya dosis susu kedelai.
English Abstract
Atherosclerosis is a complex chronic disease characterized by the accumulation of lipids within arterial walls. Accumulation of total cholesterol and LDL in the long term can form plaques that can increase the thickness of the walls of blood vessels. Flavonoids, isoflavones, vitamin C and vitamin E contained in soy milk play a role in inhibiting the oxidation of fats, especially to inhibit the oxidation of LDL cholesterol in the blood. The aim of study was to determine the effect of soy milk to the thickness of aortic wall of white rat with high fatty diet. This true experimental laboratoric study using control group post test design performed in white rat that placed in Physiology laboratory Medical Faculty of Brawijaya University. Sampling was carried out by completely random sampling with 25 rats for total sample. The results of statistical analysis using One Way ANOVA showed no significant differences between groups, but the results of the descriptive analysis showed a tendency to decrease the thickness of the vessel wall of the aorta with increasing doses of milk soybeans.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2015/76/051500900 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel > 610.73 Nursing and services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Samsul Arifin |
| Date Deposited: | 13 Feb 2015 09:12 |
| Last Modified: | 20 Oct 2021 04:52 |
| URI: | http://repository.ub.ac.id/id/eprint/125565 |
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