Sulfiana, Marnia (2015) Pengaruh Tingkat Kelembaban Kompres Cairan Betaine Polyhexanide 0.1% Terhadap Peningkatan Kepadatan Kolagen Luka Bakar Grade II A Pada Tikus Wistar Putih. Sarjana thesis, Universitas Brawijaya.
Abstract
Luka bakar grade II A merupakan luka bakar terbanyak yang terjadi di masyarakat. Perawatan luka bakar yang tidak tepat mengakibatkan perlambatan penyembuhan. Lingkungan lembab telah terbukti memfasilitasi proses penyembuhan luka dengan mencegah dehidrasi dan meningkatkan angiogenesis dan sintesis kolagen bersama-sama dengan peningkatan kerusakan jaringan yang mati dan fibrin. Betaine Polyhexanide 0,1 % digunakan untuk membersihkan dan melembabkan luka dan digunakan sebagai antibiotik dan antimikroba pada luka akut maupun kronis. Penelitian ini bertujuan untuk melihat pengaruh tingkat kelembaban kompres cairan betaine polyhexanide 0.1% terhadap peningkatan kepadatan kolagen luka bakar grade II A pada tikus wistar putih. Desain penelitian ini menggunakan true experimental laboratory post-test only control group. Luka bakar diinduksi dengan air panas menggunakan sterofoam berukuran 2 x 2 cm yang dibalut kasa lalu dipanaskan dalam air panas selama 3 menit. Sampel dipilih secara acak, dibagi ke dalam 5 kelompok yaitu kelompok NS sebagai kontrol dan 4 kelompok perlakuan : kelompok perawatan luka menggunakan kompres cairan betaine polyhexanide 0.1% dengan kelembaban 50%, 60%, 70%, dan 80%. Penelitian dilakukan selama 10 hari, pembuatan preparat histologi menggunakan pewarnaan Hematoxcylin eosin. Preparat histologi diamati menggunakan metode gridline. Hasil penelitian menunjukkan adanya perbedaan signifikan pada kelompok kontrol dan kelompok perlakuan. Kesimpulan penelitian ini yaitu perawatan luka bakar dengan kompres cairan betaine polyhexanide 0.1% dengan kelembaban yang semakin tinggi maka akan semakin meningkatkan persentase kepadatan kolagen.
English Abstract
Burns grade II is the most burns which happens in the society. An inappropriate treatment causes retardation healing. A humid environment proves that it facilitates the healing burns process by preventing dehydration and improving angiogenesis and collagen syntheses together with increasing damages in dead tissue and fibrin. Betaine Polyhexanide 0,1 % is used to clean and humidify wound and is used as antibiotics and antimicrobials in acute and chronic wounds. The purpose of this study was to find the influence of humidity compress level of Betaine Polyhexanide 0.1% liquid towards the propability improvement of colagen burns grade II A on the white wistar rat. Design of this research was true-experimental laboratory post-test only control group. Burns was induced by hot water using sterofoam sized 2 x 2 centrimetres which were wrapped in gauze and then heated in hot water for 3 minutes. Sample of this research was chosen randomly, was divided into 5 groups, namely NS group as control group and 4 groups as experimental group: burn groups used compress of Betaine Polyhexanide 0.1% liquid by humidity 50%, 60%, 70%, and 80%. This research was conducted for 10 days. Production of histology of blood smear by using coloration of Hematoxcylin eosin. Histology of blood smear was observed by using gridline method. Result of this research shows that there is a significant difference on the control groups and the experimental groups. Conclusion of this research is that burns treatment by using compress of betaine polyhexanide 0.1% liquid with higher humidity,so it will increase the precentage of collagen density.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2015/61/051500885 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel > 610.73 Nursing and services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Samsul Arifin |
| Date Deposited: | 13 Feb 2015 13:54 |
| Last Modified: | 19 Oct 2021 08:38 |
| URI: | http://repository.ub.ac.id/id/eprint/125398 |
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