Sutanto, SugengTrianugrahRamamuliawan (2015) Pengaruh Pemberian Ekstrak Etanol Daun Seledri (Apium Graveolans) Terhadap Penurunan Jumlah Lesi Perdarahan Pada Tikus Putih (Rattus Novergicus) Galur Wistar Model Ulkus Lambung. Sarjana thesis, Universitas Brawijaya.
Abstract
Seledri (Apium Graveolans) Mengandung Senyawa Flavonoid (Apigenin Dan Luteolin) Yang Memiliki Aktifitas Antioksidan Tinggi. Penilitian Ini Bertujuan Untuk Mengetahui Pengaruh Pemberian Ekstrak Etanol Daun Seledri Terhadap Penurunan Jumlah Lesi Perdarahan Pada Tikus Putih Model Ulkus Lambung. Penelitian Ini Adalah Penelitian Eksperimental Dengan Rancangan Post Test Only Control Group Design. Sampel Terdiri Dari 30 Ekor Tikus Wistar Jantan Usia 2-3 Bulan Yang Diadaptasi Dahulu Selama 1 Minggu Lalu Dibagi Rata Menjadi 5 Kelompok, Yaitu Kelompok Kontrol Negatif (N) Dan Positif (P) Dan 3 Kelompok Perlakuan (P1,P2,P3) Secara Acak, Kemudian Diberikan Diet Standard Dan Ekstrak Etanol Daun Seledri Selama 5 Hari. Kelompok Kontrol Negatif Diberi Pakan Standar Sedangkan Kelompok Kontrol Positif Diberi Pakan Standar Dan Indometasin. Ketiga Kelompok Perlakuan (P1,P2,P3) Diberikan Diet Indometasin+Ekstrak Etanol Daun Seledri Dengan Dosis Masing-Masing 200mg/Kgbb, 300mg/Kgbb Dan 400mg/Kgbb Selama 5 Hari. Pemberian Indometasin Pada Kelompok Kontrol Positif Dan Perlakuan Menggunakan Dosis 30 Mg/Kgbb. Jumlah Lesi Perdarahan Pada Kelompok Kontrol Negatif (0 ± 0); Kontrol Positif (36.60 ± 7.335); Perlakuan P1 (26.20 ± 6.340); P2 (20.40 ± 6.504); Dan P3 (12.00 ± 1.581). Uji One-Way Anova Menunjukkan Terdapat Perbedaan Bermakna Antar Semua Kelompok. Berdasarkan Uji Post Hoct Test Dapat Disimpulkan Bahwa Terdapat Perbedaan Signifikan Antara Kelompok Negatif Dengan Kelompok Positif Dan Kelompok Perlakuan, Dan Antara Kelompok P1 Dan P3 (P=0,000), Tidak Terdapat Perbedaan Signifikan Antara Kelompok P1 Dengan Kelompok P2 (P=0,433), Kelompok P2 Dengan Kelompok P3 (P=0,125). Pemberian Ekstrak Etanol Daun Seledri Dosis 400mg/Kgbb Mampu Menurunkan Jumlah Lesi Perdarahan Lebih Baik Dibanding Dosis Lain Pada Tikus Putih Model Ulkus Lambung.
English Abstract
Celery (Apium Graveolens) Contains Flavonoids (Apigenin And Luteolin) Which Has A High Antioxidant Activity. This Research Aims To Determine The Effect Of Ethanol Extract Of Celery To Decrease The Amount Of Bleeding Lesions In The Rat Model Of Gastric Ulcer. This Study Is An Experimental Study With The Draft Post Test Only Control Group Design. The Sample Consisted Of 30 Male Wistar Rats Aged 2-3 Months Who Previously Adapted For 1 Week And Then Divided Equally Into 5 Groups: Negative Control Group (N) And Positive (P) And The 3 Treatment Groups (P1, P2, P3) Randomly, Then Given A Standard Diet And Ethanol Exstract Celery Leaves For 5 Days. Negative Control Group Was Fed A Standard And Positive Control Group Was Fed A Standard And Indomethacin. All Three Treatment Groups (P1, P2, P3) Is Given Indomethacin Diet + Ethanol Extract Of Celery With Each Dose Of 200mg / Kg, 300mg / Kg And 400mg / Kg For 5 Days. Provision Of Indomethacin On The Positive Control And Treatment Groups Using A Dose Of 30 Mg / Kg. The Number Of Bleeding Lesions In The Negative Control Group (0 ± 0); Positive Controls (36.60 ± 7335); P1 Treatment (26.20 ± 6340); P2 (20:40 ± 6504); And P3 (12.00 ± 1.581). One-Way Anova Test Showed That There Were Significant Differences Among All Groups. Based On The Hoct Post Test Can Be Concluded That There Are Significant Differences Between The Groups And The Negative With The Positive Group And Treatment Group , Between Groups P1 And P3 (P = 0.000), There Was No Significant Difference Between Groups P1 To P2 Group (P = 0.433), The Group P2 To P3 Group (P = 0.125). Giving Ethanol Extract Of Celery Dose Of 400mg / Kg Were Able To Decrease The Amount Of Bleeding Lesions Better Than The Other Dose On White Mouse With Gastric Ulcers Model.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2015/449/051503648 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel > 610.73 Nursing and services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 04 Jun 2015 09:33 |
| Last Modified: | 19 Oct 2021 03:59 |
| URI: | http://repository.ub.ac.id/id/eprint/125222 |
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