Ghifary, FaathirBaihaqi (2015) Uji Toksisitas Sub Kronis Ekstrak Pericarp Garcinia Mangostana Linn pada Rattus norvegicus Strain Wistar : Studi terhadap kadar SGOT dan SGPT. Sarjana thesis, Universitas Brawijaya.
Abstract
Ekstrak Kulit Manggis (Garcinia Mangostana Linn. ) adalah salah satu bahan obat yang seringkali digunakan sebagai obat herbal. Pada penelitian sebelumnya didapatkan kesimpulan bahwa ekstrak kulit manggis mampu berfungsi sebagai anti oksidan anti tumor, anti allergi, anti inflamasi, anti bakteri dan antiviral . Untuk dapat dinaytakan aman untuk dikonsumsi manusia dibutuhkan serangkaian pengujian kemanann obat. Tujuan dari penelitian ini adalah untuk mengetahui apakah pemberian Ekstrak Kulit Manggis secara sub kronis dapat meningkatkan kadar Enzim SGPT dan SGOT dalam darah yang menunjukkan efek hepatotoksik. Penelitian ini menggunakan desain eksperimen murni (true eksperimental) yang dikerjakan di laboratorium secara in vivo dengan menggunakan rancangan percobaan Post Test Only Control Group Design. hewan coba dibagi Hewan uji coba tikus terdiri dari 5 kelompok jantan dan 5 kelompok betina yang diberi pakan normal serta pada kelompok perlakuan diberikan Ekstrak Kulit Manggis sebesar 200mg/tikus/hari, 400mg/tikus/hari, 800mg/tikus/hari, 1600mg/tikus/hari. Analisa Data menggunakan Uji One Way ANOVA serta Multi comparison LSD Hasil pemeriksaan kadar SGOT dan SGPT antar kelompok menunjukkan perbedaan bermakna pada kadar SGOT dan SGPT Betina dan SGPT Jantan serta tidak terdapat perbedaan pada kadar SGOT Jantan dengan nilai signifikansi masing-masing 0,040 (SGPT Janta) ,0,037 (SGPT Jantan),dam 0,000 (SGOT Betina) namun belum dapat dinyatakan member manifestasi klinis, sehingga dapat disimpulkan bahwa Pemberian Ekstrak Kulit Manggis terhadap Rattus Novergius dengan perbedaan dosis tidak memberi perbedaan bermakna. Kesimpulan dari penelitian ini adalah tidak dapat dibuktikan adanya efek hepatotoksik pada hepar
English Abstract
Crude Extract Mangosteen Pericarp (Garcinia Mangostana Linn.) Is one of the ingredients that are often used as a herbal medicine. In previous studies it was concluded that the mangosteen pericarp extract is able to function as an anti-oxidant anti-tumor, anti-allergic, anti-inflammatory, antibacterial and antiviral . To be safe for human consumption , its needed to run for drug test series for safety . The aim of this study was to determine does giving mangosteen pericarp extract sub-chronic can increase the levels of SGPT and SGOT enzymes in the blood that indicate hepatotoxic effects. This study used true experimental design were done in the laboratory in vivo by using Post Test Only Control Group Design. Experimental animals were divided into five groups of rats male and 5 female groups were fed a normal as well as in the treatment group was given mangosteen pericarp extract of 200 mg / rat / day, 400 mg / rat / day, 800 mg / rat / day, 1600mg / mice /day. Data Analysis using One Way ANOVA and LSD comparison Multi examination results Female SGOT and SGPT levels,Male SGPT between groups showed significant difference meanwhile there is no significant different on Male SGOT serum level. Value of Sinificancy are 0,040 (Male SGPT ) ,0,037 (Female SGPT ),dam 0,000 (Female SGOT) and 0,392 on (Male SGOT). It could not to be state having clinical manifestation because its elevation are no more than two times than upper limit of normal value. So it can be concluded that the exposure of Mangosteen pericarp extract toward Rattus Norvergius with different dose not give hepatotoxic effect .
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2015/275/051502013 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Samsul Arifin |
| Date Deposited: | 11 Mar 2015 11:47 |
| Last Modified: | 19 Oct 2021 00:10 |
| URI: | http://repository.ub.ac.id/id/eprint/125032 |
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