Rahmi, DitaOktavia (2015) Korelasi sensitisasi alergen dengan derajat penyakit asma pada pasien asma anak. Sarjana thesis, Universitas Brawijaya.
Abstract
Definisi asma menurut GINA yaitu gangguan inflammasi kronik saluran nafas yang disertai oleh peranan berbagai sel, khususnya sel mast, eosinophil, dan limfosit T. inflammasi tersebut menyebabkan mengi berulang, sesak nafas, rasa dada tertekan, dan batuk, khusunya malam atau dini hari. Prevalensi asma meningkat di sebagian besar negara, terutama di kalangan anak-anak. Alergi merupakan salah satu faktor risiko asma. Belum banyak penelitian tentang hubungan faktor risiko asma dengan derajat asma khususnya derajat penyakit asma pada pasien asma anak.Tujuan dari penelitian ini adalah untuk mengetahui korelasi antara sensitisasi alergen dengan derajat penyakit asma pada pasien asma anak.Penelitian ini merupakan penelitian observasional desain potong lintang dengan analisis korelatif. Subyek merupakan pasien asma anak di Poli Respirologi dan Alergi Imunologi Rumah Sakit dr Saiful Anwar Malang periode Desember 2011 sampai dengan Desember 2014.Hitung besar sampel didapatkan 85 sampel. Dilakukan penderajatan berdasarkan PNAA dan SPT untuk konfirmasi alergen berupa aeroalergen dan alergen makanan. Analisis statistik menggunakan Spearman. Hasilnya didapat Subyek 171 anak terdiri dari 89 (52,04%) anak dengan asma episodik jarang, 77 (45,03%) anak dengan asma episodik sering, dan 5 (2,92%) anak dengan asma persisten. Sensitisasi alergen negatif 8 (4,7%), tersensitisasi mono alergen 40 (23,4%), dan tersensitisasi multiple alergen 123 (71,9%). Nilai probabilitas (p=0,029) dan koefisiien korelasi (r=0,243).Sehingga apatdisimpulkan bahwa terdapat korelasi yang bermakna antara sensitisasi alergen dengan derajat penyakit asma pada pasien asma anak namun memiliki kekuatan korelasi lemah
English Abstract
The definition of asthma according to GINA is a chronic inflammatory airway disorders accompanied by the role of various cells, in particular mast cells, eosinophil and T lymphocytes inflammation causes recurrent wheezing, shortness of breath, chest tightness, and coughing, particularly at night or early morning. The prevalence of asthma increased in most countries, especially among children. Allergy is one of risk factor for asthma. It has not been many researches for correlation between asthma degree of disease and risk factors of asthma particularly in childhood asthma.The purpose of this study is to determine the correlation between allergen sensitization with the disease degree of asthma in childhood asthma.This study is a cross-sectional observational study design with correlative analysis. The subjects are children with asthma in Respirology and Allergy Immunology Unit in Dr. Saiful Anwar Hospital period December 2011 to December 2014. Calculating of sample size is obtained 85 samples. It has been determined for disease degree of asthma based on PNAA and SPT for confirmation to allergens sensitization such as aeroallergens and food allergens. Statistical analysis is by using Spearman.The results is obtained 171 children with asthma consisted of 89 (52.04%) children with infrequent episodic asthma, 77 (45.03%) children with frequent episodic asthma, and 5 (2.92%) children with persistent asthma. Negative allergen sensitization 8 (4.7%), mono sensitized to allergens 40 (23.4%), and multiple allergen sensitized 123 (71.9%). Probability value (p = 0.029) and correlation coefficient (r = 0.243).So it can be concluded that there is a significant correlation between allergen sensitization with asthma degree of disease in childhood asthma but has a weak correlation in strength of correlation.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2015/248/051501928 |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Samsul Arifin |
| Date Deposited: | 12 Mar 2015 10:34 |
| Last Modified: | 18 Oct 2021 23:46 |
| URI: | http://repository.ub.ac.id/id/eprint/125002 |
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