Juliana, Lauran (2015) Pengaruh Pemberian Susu Kedelai (Glycine max) Terhadap Peningkatan Aktivitas Enzim Superoxide Dismutase (Sod) pada Tikus (Rattus norvegicus strain Wistar) yang Diberi Diet Tinggi Lemak. Sarjana thesis, Universitas Brawijaya.
Abstract
Efek merugikan hiperkolesterolemia dianggap merupakan faktor terpenting sebagai penyebab aterosklerosis. Menurut World Health Organitation (WHO) pada tahun 2008, peningkatan kolesterol total sebagai faktor resiko penyakit diperkirakan terus meningkat. Hiperkolesterolemia oleh diet tinggi lemak menyebabkan peningkatan produksi radikal bebas (anion superoksida) yang dapat merusak jaringan. Susu kedelai (Glycine max) dengan kandungan isoflavon mampu meningkatkan aktivitas enzim Superoxide Dismutase (SOD) dalam tubuh sebagai antioksidan endogenus dengan cara menetralisir radikal superoksida. Tujuan penelitian ini adalah mengetahui efek susu kedelai terhadap aktivitas enzim SOD pada tikus (Rattus norvegicus strain Wistar) yang diberi diet tinggi lemak. Penelitian ini merupakan penelitian eksperimen murni menggunakan Randomized Post test Only Control Group Design pada 5 kelompok hewan coba tikus (n=4) yang diberi diet normal (K-), diet tinggi lemak (K+), dan kelompok perlakuan dosis susu kedelai 0,81, 1,62, dan 3,24 gram/tikus/hari dalam 3 ml aquadest (P1, P2,P3). Data aktivitas enzim SOD dianalisa menggunakan One Way ANOVA menunjukan tidak ada perbedaan yang signifikan antar kelompok. Sedangkan, hasil analisis deskriptif menunjukan peningkatan aktivitas enzim SOD pada kelompok perlakuan P3, sehingga kesimpulan penelitian ini adalah susu kedelai memberikan pengaruh terhadap peningkatan aktivitas enzim SOD, namun tidak signifikan.
English Abstract
Adverse effects of hypercholesterolemia is considered an important factor as a cause of atherosclerosis. According to the World Health Organitation (WHO) in 2008, an increase in total cholesterol as a risk factor for the disease is expected to increase. Hypercholesterolemia by high-fat diet led to increased production of free radicals (superoxide anion) which can damage the tissue. Milk Soy (Glycine max) with isoflavone content can increase the activity of the enzyme superoxide dismutase (SOD) in the body as an antioxidant by neutralizing endogenous superoxide radicals. The purpose of this study was to determine the effects of soy milk on SOD enzyme activity in rats(Rattus norvegicus Wistar strain) were given a high-fat diet. This study is a pure experiment using Randomized Post Test Only Control Group Design in 5 groups of rats (n = 4 ) were given a normal diet (K), high-fat diet (K +), and soy milk-dose treatment group of 0.81, 1.62, and 3.24 g / rat / day in 3 ml of distilled water (P1, P2, P3 ). SOD enzyme activity data were analyzed using One Way ANOVA showed no significant differences between groups. Meanwhile, the results of the descriptive analysis showed increased activity of SOD in the treatment group P3, so that the conclusions of this study is the soy milk to give effect to an increase in the activity of SOD, but not significant.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2015/140/051501116 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel > 610.73 Nursing and services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Samsul Arifin |
| Date Deposited: | 13 Feb 2015 15:16 |
| Last Modified: | 22 Oct 2021 05:51 |
| URI: | http://repository.ub.ac.id/id/eprint/124882 |
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