Devi, GustiAyuPuspita (2014) Efektifitas Ekstrak Etanol Daun Kelor (Moringa Oleifera) Sebagai Antifungal Terhadap Candida Albicans Secara In Vitro. Sarjana thesis, Universitas Brawijaya.
Abstract
Infeksi Candida Albicans Menyebabkan Timbulnya Kandidiasis, Dimana Infeksi Ini Banyak Terjadi Baik Pada Bayi, Remaja, Maupun Ibu Hamil. Obat-Obatan Antifungal Memiliki Berbagai Efek Samping Yang Merugikan, Oleh Karena Itu Banyak Berkembang Obat Herbal Yang Dijadikan Sebagai Antifungal. Salah Satunya Adalah Daun Kelor, Dimana Daun Kelor Mengandung Alkaloid, Tanin, Steroid, Flavonoid, Dan Minyak Atsiri Yang Kerjanya Pada Tanaman Lain Dapat Mengahambat Candida Albicans. Tujuan Dari Penelitian Ini Adalah Untuk Membuktikan Bahwa Ekstrak Etanol Daun Kelor (Moringa Oleifera) Memiliki Efek Antifungal Terhadap C. Albicans Secara In Vitro. Penelitian Ini Menggunakan Metode Dilusi Agar Dengan Sampel Uji Berupa Empat Isolat Candida Albicans Swab Vagina. Bahan Uji Yang Digunakan Adalah Ekstrak Etanol Daun Kelor (Moringa Oleifera) Yang Dibuat Dengan Metode Maserasi Dengan Konsentrasi 0%, 12,5%, 15%, 17,5%, 20%, 22,5%, Dan 25%. Hasil Uji Analisis Kruskal-Wallis Didapatkan Perbedaan Yang Signifikan (P=0,000), Kemudian Uji Lanjutan Dengan Mann-Whitney. Uji Korelasi Spearman Menunjukkan Terdapat Hubungan Antara Kenaikan Konsentrasi Ekstrak Etanol Daun Kelor Dengan Pengurangan Jumlah Koloni Candida Albicans (R= -0,946) Dan Uji Korelasi Ini Menunjukkan Terdapat Hubungan Yang Kuat Antara Pemberian Konsentrasi Ekstrak Etanol Daun Kelor Terhadap Pertumbuhan Candida Albicans (P=0,000). Dari Penelitian Ini Dapat Disimpulkan Bahwa Ekstrak Etanol Daun Kelor Efektif Dalam Menghambat Pertumbuhan Koloni Candida Albicans Dengan Kadar Hambat Minimal (Khm) Pada Konsentrasi 22,5%. Perlu Dilakukan Penelitian Lebih Lanjut Efektifitas Ekstrak Etanol Daun Kelor Dalam Menghambat Pertumbuhan Candida Albicans Secara In Vivo.
English Abstract
Candidiasis Ofter Occur In Infants, Adolescents, And Pregnant Woman Caused By Candida Albicans Infection. Antifungal Drugs Have Adverse Side Effects, Therefore Many Herbal Remedies Are Developed As Antifungal. One Of Them Are Moringa Leaves Which Contains Alkaloids, Tannins, Steroids, Flavonoids, Reduced Sugar, And Essential Oils. These Substances Are Present In Other Plants And Able To Inhibit Candida Albicans. The Purpose Of This Study Was To Prove That The Ethanol Extract In Moringa Leaves (Moringa Oleifera) Has Antifungal Effect Against C. Albicans In Vitro. This Research Is Conducted Using Dilution Method In Order To Test Formation Of Four Candida Albicans Vaginal Swab Isolates. Material Used Were Ethanol Extracted From Moringa Leaves (Moringa Oleifera) Using Maceration Method With Various Concentrations Of 0%, 12.5%, 15%, 17.5%, 20%, 22.5%, And 25%. Results Of Kruskal - Wallis Test Were Significant Difference (P=0.000), And Further With Mann - Whitney Test. Spearman Test Showed A Relationship Between The Increasing Of Ethanol Concentration Of Moringa Leaves With The Reduction In The Number Of Candida Albicans Colonies (R= -0.946) And The Test Showed Significant Relationship Between Addition Of Ethanol Extract From Moringa Leaves And Growth Of Candida Albicans (P=0,000). It Can Be Concluded That The Ethanol Extract Of Moringa Leaves Is Effective In Inhibiting The Growth Of Candida Albicans Colonies With Minimum Inhibitory Concentration (Mic) At 22.5%. Further Research Needs To Be Done On Effectiveness Of Ethanol Extract In Moringa Leaves To Prevent The Growth Of Candida Albicans By In Vivo
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/711/051500287 |
| Subjects: | 600 Technology (Applied sciences) > 618 Gynecology, obstetrics, pediatrics, geriatrics > 618.2 Obstetrics |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 20 Jan 2015 10:22 |
| Last Modified: | 22 Oct 2021 05:55 |
| URI: | http://repository.ub.ac.id/id/eprint/124735 |
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