Pratiwi, NiKadekNensiDwi (2014) Efek Antifungi Ekstrak Etanol Daun Lidah Mertua (Sansevieria Trifasciata Var.Laurentii) Terhadap Candida Albicans Isolat 1148-Sv Secara In Vitro. Sarjana thesis, Universitas Brawijaya.
Abstract
Kandidiasis Merupakan Suatu Infeksi Yang Disebabkan Oleh Candida Albicans. Terapi Antifungi Yang Tersedia Saat Ini Memiliki Resistensi Yang Cukup Tinggi Dan Efek Samping Terapi. Oleh Karena Itu Perlu Dilakukan Penelitian Untuk Mendapatkan Antifungi Alternatif. Antifungi Alternatif Tersebut Adalah Daun Lidah Mertua (Sansevieria Trifasciata Var.Laurentii) Yang Memiliki Kandungan Zat Aktif Seperti Alkaloid, Flavonoid, Saponin, Tannin, Dan Terpenoid. Penelitian Ini Bertujuan Untuk Membuktikan Bahwa Ekstrak Etanol Daun Lidah Mertua Mempunyai Efek Antifungi Terhadap Candida Albicans Secara In Vitro. Penelitian Ini Menggunakan Desain Eksperimental Laboratorium Dengan Metode Dilusi Tabung Yang Terdiri Dari Tahap Penentuan Kadar Hambat Minimum (Khm) Dan Kadar Bunuh Minimum (Kbm). Konsentrasi Ekstrak Yang Digunakan Yaitu 0%, 5%, 6%, 7%, 8% Dan 9%, Sedangkan Konsentrasi Candida Albicans Adalah 1,3 X 104cfu/Ml. Kadar Hambat Minimum (Khm) Dari Penelitian Ini Adalah 8% Dan Kadar Bunuh Minimum (Kbm) Adalah 9%. Hasil Statistik One-Way Anova Menunjukkan Terdapat Perbedaan Yang Signifikan Pada Perubahan Konsentrasi Ekstrak Terhadap Jumlah Koloni Candida Albicans (P=0,000) Dan Terdapat Hubungan Yang Erat Antara Konsentrasi Ekstrak Dengan Jumlah Koloni (R= -0,913). Uji Korelasi Menunjukkan Semakin Tinggi Konsentrasi Ekstrak Etanol Daun Lidah Mertua, Maka Semakin Rendah Jumlah Pertumbuhan Koloni. Berdasarkan Penelitian Ini, Dapat Disimpulkan Bahwa Ekstrak Etanol Daun Lidah Mertua Mempunyai Efek Antifungi Terhadap Candida Albicans.
English Abstract
Candidiasis Is A Fungal Infection Caused By Candida Albicans. Antifungal Therapy Has A High Resistance And Side Effects Of Therapy. It Is Therefore Necessary To Study To Get An Alternative Antifungal. The Alternative Antifungal Is Leaf Of Lidah Mertua (Sansevieria Trifasciata Var.Laurentii), That Contents Of Active Essence Inside As Alkaloids, Flavonoids, Tannins, Saponins And Terpenoids. This Study Aims To Prove That The Ethanol Extract Of The Leaves Of The Lidah Mertua Has Antifungal Effect Against Candida Albicans In Vitro. This Study Used A Laboratory Experimental Design With Tube Dilution Method Comprising The Steps Of Determining The Minimum Inhibitory Concentration (Mic) And Minimum Fungicidal Concentration (Mfc). The Concentration Of Extract Used Was 0%, 5%, 6%, 7%, 8%, And 9%, And The Concentration Of Candida Albicans Was 1,3 X 104cfu/Ml. Minimum Inhibitory Concentration (Mic) Of The Study Was 8% And Minimum Fungicidal Concentration (Mfc) Was 9%. The Result Of One-Way Anova Statistic Showed That There Is A Significant Difference In The Change In Concentration Of Extract To The Number Of Colonies Of Candida Albicans (P=0.000) And There Is A Close Relationship Between The Concentration Of Extract With The Number Of Colonies (R= -0.913). The Correlation Test Showed That The Higher Concentration Of Extract, The Less Number Of Colony Growth. Based On This Research, It Can Be Concluded That The Concentration Of Ethanol Extract Of The Leaves Of Lidah Mertua Has An Antifungal Effect Against Candida Albicans.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/706/051500200 |
| Subjects: | 600 Technology (Applied sciences) > 618 Gynecology, obstetrics, pediatrics, geriatrics > 618.2 Obstetrics |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 16 Jan 2015 08:07 |
| Last Modified: | 22 Oct 2021 05:48 |
| URI: | http://repository.ub.ac.id/id/eprint/124729 |
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