Prabawati, Linda (2014) Optimasi Fast Disintegrating Tablet Ranitidin Hidroklorida dengan Menggunakan Metode Simplex Lattice Design. Sarjana thesis, Universitas Brawijaya.
Abstract
Gastroesophageal reflux disease (GERD) adalah suatu kondisi terjadinya kerusakan mukosa yang diakibatkan oleh aliran kembali isi lambung menuju esofagus. Gejala yang umum terjadi yaitu dada terasa terbakar dan kesulitan menelan. Salah satu strategi mengatasi masalah kesulitan menelan pada pasien GERD adalah melalui pengembangan bentuk sediaan padat tanpa memerlukan waktu hancur lebih lama dalam rongga mulut. Bentuk sediaan tablet tersebut adalah fast disintegrating tablet (FDT). Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi dan perbandingan kadar chitosan dan sodium starch glycolate yang dapat mempengaruhi sifat fisik FDT Ranitidin HCl. Tiga formula FDT Ranitidin HCl dirancang berdasarkan metode simplex lattice design dengan perbandingan chitosan : sodium starch glycolate sebagai berikut: F I (0% : 100%), F II (50% : 50%), F III (100% : 0%). Metode granulasi basah dilakukan untuk pembuatan FDT Ranitidin HCl. FDT Ranitidin HCl yang diperoleh kemudian diuji sifat fisiknya meliputi kekerasan, kerapuhan, waktu hancur, waktu keterbasahan, dan disolusi. Hasil uji sifat fisik dianalisis menggunakan One Way ANOVA pada batas kepercayaan α = 0,05. Uji Tukey dilakukan untuk menguji pengaruh kombinasi chitosan dan sodium starch glycolate terhadap sifat fisik FDT Ranitidin HCl, serta menguji perbandingan kadar chitosan dan sodium starch glycolate yang dapat menghasilkan FDT Ranitidin HCl yang memiliki sifat fisik optimum. Hasil penelitian yang diperoleh yaitu kombinasi chitosan dan sodium starch glycolate dapat meningkatkan waktu disintegrasi FDT Ranitidin HCl dan memberikan sifat fisik tablet yang optimum. Formula optimum FDT Ranitidin HCl berdasarkan metode simplex lattice design adalah formula dengan kombinasi chitosan 50% : sodium starch glycolate 50%. Sedangkan formula optimum FDT Ranitidin HCl berdasarkan trial setelah simplex lattice design adalah formula dengan kombinasi chitosan 40% : sodium starch glycolate 60% yang dapat memberikan sifat fisik tablet yang optimum.
English Abstract
Gastroesophageal reflux disease (GERD) is a condition of the occurrence of mucosal damage caused by the back flow of stomach contents to the esophagus. Common symptoms are heart burn and dysphagia. One strategy to overcome problems dysphagia in patients with GERD is through the development of solid dosage forms without the need for a longer disintegration time in the oral cavity. The innovated dosage forms is fast disintegrating tablet (FDT). The purpose of this study was to determine the effect of the combination and comparison of concentrations of chitosan and sodium starch glycolate which may affect the physical properties of Ranitidine HCl FDT. Three Ranitidine HCl FDT formulas designed by the simplex lattice design method with a ratio of chitosan : sodium starch glycolate as follows: FI (0% : 100%), F II (50% : 50%), F III (100% : 0%). Wet granulation method performed for the manufacture of Ranitidine HCl FDT. Ranitidine HCl FDT has been obtained and tested for physical properties include hardness, friability, disintegration time, wetting time, and dissolution. Physical properties of the test results were analyzed using One Way ANOVA at α = 0.05. Tukey test conducted to examine the effect of the combination of chitosan and sodium starch glycolate on the physical properties of Ranitidine HCl FDT, and a comparison test concentrations of chitosan and sodium starch glycolate which may produces Ranitidine HCl FDT which have optimum physical properties. The results obtained are a combination of chitosan and sodium starch glycolate can increase the disintegration time Ranitidine HCl FDT and provide optimum physical properties. Optimum formula of Ranitidine HCl FDT based simplex lattice design method is a formula with a combination of 50% chitosan: 50% sodium starch glycolate. While the optimum formula Ranitidine HCl FDT based on trial after simplex lattice design is a formula with a combination of 40% chitosan: 60% sodium starch glycolate which can provide optimum physical properties of tablets.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2014/505/051403776 |
| Uncontrolled Keywords: | fast disintegrating tablet, ranitidin hidroklorida, simplex lattice design; fast disintegrating tablets, ranitidine hydrochloride, simplex lattice design |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.19 Pharmaceutical chemistry |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | Hasbi |
| Date Deposited: | 11 Jul 2014 09:35 |
| Last Modified: | 03 Dec 2021 07:28 |
| URI: | http://repository.ub.ac.id/id/eprint/124507 |
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