Lestari, PutiFajri (2013) Uji Efektivitas Ekstrak Daun Ceremai (Phyllanthus acidus (L.) Skeels.) sebagai Antimikroba terhadap Bakteri Salmonella Typhi secara In Vitro’. Sarjana thesis, Universitas Brawijaya.
Abstract
Salmonella Typhi adalah bakteri batang Gram negatif yang dapat menyebabkan berbagai penyakit pada manusia termasuk demam tifoid. Salmonella Typhi cepat menjadi resisten terhadap banyak obat antimikroba sehingga menimbulkan masalah terapi yang sulit. Salah satu alternatif terapi adalah dengan bahan alami, yaitu daun ceremai (Phyllanthus acidus (L.) Skeels.). Daun ceremai mengandung senyawa aktif seperti saponin, tanin, flavonoid, dan alkaloid. Senyawa aktif ini bermanfaat sebagai antimikroba. Penelitian ini bertujuan untuk mengetahui efek ekstrak daun ceremai sebagai antimikroba terhadap Salmonella Typhi secara in vitro. Pada penelitian ini digunakan rancangan penelitian True Experimental Post Test Only Control Group Design dengan empat kali pengulangan. Konsentrasi ekstrak daun ceremai yang digunakan pada penelitian ini adalah 0%, 16%, 18%, 20%, 22%, 24%, dan 26%. Metode yang digunakan untuk menentukan Kadar Hambat Minimum (KHM) adalah dilusi tabung dan didapatkan KHM pada konsentrasi 22%. Metode yang digunakan untuk menentukan Kadar Bunuh Minimum (KBM) adalah dilusi tabung dengan penanaman pada media Nutrient Agar Plate (NAP) dan didapatkan KBM pada konsentrasi 26%. Hasil statistik One way ANNOVA menunjukkan terdapat perbedaan jumlah koloni bakteri Salmonella Typhi yang bermakna pada berbagai konsentrasi ekstrak daun ceremai (p < 0,05). Uji korelasi Pearson menunjukkan terdapat korelasi yang bermakna antara konsentrasi ekstrak daun ceremai terhadap jumlah koloni bakteri Salmonella Typhi dengan nilai signifikansi sebesar 0,000 (p < 0,05) dan hubungan yang sangat kuat antara konsentrasi ekstrak daun ceremai dengan jumlah koloni bakteri Salmonella Typhi (Koefisien Korelasi, r = -0,900). Dengan demikian, dapat disimpulkan bahwa ekstrak daun ceguk mempunyai efek antimikroba terhadap Salmonella Typhi secara in vitro.
English Abstract
Salmonella Typhi is a Gram-negative bacteria stems that can cause various diseases in humans, including typhoid fever. Salmonella Typhi is quickly becoming resistant to many antimicrobial drugs and lead to a difficult therapeutic problems. One natural alternative therapy that can be used is ceremai leaf (Phyllanthus acidus (L.) Skeels.). Ceremai leaf contains active compounds such as saponin, tanin, flavonoid, and alkaloid. These active compounds of ceremai leaf have antimicrobial activity.This study was conducted to know antimicrobial effect of ceremai leaf extract to Salmonella Typhi in vitro. This experimental study used was the Post Test Only Control Group Design with four times research repetition. Extract concentrations used were 0%, 16%, 18%, 20%, 22%, 24%, and 26%. Methods used to determine the Minimum Inhibitory Concentration (MIC) was tube dilution and the MIC was found at 22%. Methods used to determine the Minimum Bactericidal Concentration (MBC) was tube dilution by using Nutrient Agar Plate (NAP) medium and the MBC was found at 26%. Statistical result using One way ANNOVA showed significant difference of the number of Salmonella Typhi colonies toward concentrations of ceremai leaf extract with the significant value is 0,000 (p < 0,05). The Pearson correlation test showed a significant correlation between concentrations of ceremai leaf extract and the number of Salmonella Typhi colonies with the significant value is 0,000 (p < 0,05) and a very strong correlation between concentrations of ceremai leaf extract and the number of Salmonella Typhi colonies (Coefficient Correlation, r = -0,900). It can be concluded that ceremai leaf extract has the antimicrobial effect against Salmonella Typhi in vitro.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/700/051401456 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Endang Susworini |
| Date Deposited: | 26 Feb 2014 14:05 |
| Last Modified: | 21 Oct 2021 04:29 |
| URI: | http://repository.ub.ac.id/id/eprint/123993 |
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