Negara, RezaFitraKusuma (2013) Pengaruh Perawatan Luka Bakar Derajat II Menggunakan Ekstrak Etanol Daun Sirih (Piper Betle Linn.) Terhadap PeningkatanKetebalan Jaringan Granulasi Pada Tikus Putih (Rattus Norvegicus Galur Wistar) Ja. Sarjana thesis, Universitas Brawijaya.
Abstract
Luka bakar sering terjadi di rumah dan ditemukan terbanyak adalah luka bakar derajat II. Daun sirih (Piper betle Linn.) adalah bahan alam yang memiliki kandungan aktif seperti saponin, tannin, flavonoid, minyak atsiri dan diduga dapat membantu mempercepat proses penyembuhan luka, khususnya pembentukan jaringan granulasi. Jaringan granulasi merupakanpertumbuhan jaringan baru yang terjadi ketika luka mengalami proses penyembuhan dan pembentukannya merupakan salah satu komponen penting dalam penyembuhan luka.Tujuan penelitian ini adalah untuk mengetahui pengaruh perawatan luka bakar derajat II secara topikal menggunakan ekstrak daun sirih (Piper betle Linn.) terhadap peningkatan ketebalan jaringan granulasi pada tikus putih (Rattus norvegicusgalur Wistar) jantan. Desain penelitian menggunakantrue-experiment post-test dilakukan terhadap hewan coba tikus putih (Rattus norvegicus galur Wistar) jantan. Sampel diambil dengan teknik rancangan acak kelompok dan dibagi dalam empat kelompok yaitu 3 perlakuan ekstrak daun sirih: konsentrasi 15% (n=6), 30%(n=6), 45% (n=6), dan kelompok kontrol dengan NS (n=6). Data yang diukur adalah ketebalan jaringan granulasi pasca perawatan luka bakar selama 14 hari. Analisis data pada variabel menggunakan uji One-Way ANOVA dengan p = 0,04 (p < 0,05).Melalui uji Post Hoc Test dapat dilihat bahwa perlakuan yang paling signifikan ditunjukkanoleh konsentrasi daun sirih 45% denganp=0,03 (p < 0,05).Dari penelitian ini dapat disimpulkan bahwa perawatan luka bakar derajat II menggunakan ekstrak etanol daun sirih (Piper betle Linn) mempengaruhi peningkatan ketebalan jaringan granulasi.
English Abstract
Burns most often occur at home and found that second degree burns is the highest prevalence. Sirih leaves (Piper betle Linn.) arenatural materials that have active substances such as saponin, tannin, flavonoid, essential oil and supposedly can promote wound healing process, especially in granulation tissue formation. Granulation tissue is growth of new tissue that occurs when the process of wound healing in progress and its formation one of important component in wound healing. The aim of this study is to find out the effect of second degree burn topicaltreatment using the extract of sirih leaves (Piper betleLinn.) toward the granulation tissue thickness in male white rats (Rattus norvegicus strain Wistar). True-experimental post-test design was used and conducted to male white rats. Samples taken with a randomized block design and divided into four groupswhich 3 of them were treated using Piper betle Linn.extract with variety of concentrate: 15% (n=6), 30% (n=6), 45% (n=6), and NS 0,9% served as control. Granulation tissue thickness was measured after second degree burn treatment for 14 days. One-Way ANOVA test shows that there is a significant difference of granulation tissue thickness among each group withp=0,04 (p < 0,05).Post Hoc Test demonstrated that 45% dose was the best concentrate to optimize granulation tissue formation with p= 0,03 (p < 0,05). From this study, it can be concluded that the second degree burn treatmentsusing the ethanol extract of sirih leaves (Piper betle Linn.) affects the increasing of granulation tissue formation
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2013/443/051305847 |
| Subjects: | 600 Technology (Applied sciences) > 610 Medicine and health > 610.7 Education, research, nursing, services of allied health personnel > 610.73 Nursing and services of allied health personnel |
| Divisions: | Fakultas Kedokteran > Ilmu Keperawatan |
| Depositing User: | Hasbi |
| Date Deposited: | 30 Jul 2013 08:53 |
| Last Modified: | 19 Oct 2021 01:56 |
| URI: | http://repository.ub.ac.id/id/eprint/123726 |
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