Santi, Alif Zulis (2018) Pengaruh Gel Ekstrak Daun Salam (Syzygium Polyanthum) Terhadap Jumlah Fibroblas Pada Penyembuhan Luka Pasca Gingivektomi Pada Tikus Putih (Rattus Norvegicus). Sarjana thesis, Universitas Brawijaya.
Abstract
Pembesaran gingiva (Gingival enlargement) adalah penambahan ukuran gingiva yang berlebih. Gingivektomi merupakan salah satu fase bedah dalam terapi periodontal untuk eliminasi poket jaringan gingiva. Daun salam (syzygium polyanthum) mengandung zat aktif, seperti saponin, flavonoid, tanin yang dapat mempercepat penyembuhan luka. Tujuan penelitian ini adalah mengetahui pengaruh gel ekstrak daun salam (syzygium polyanthumi) pada penyembuhan luka pasca gingivektomi pada tikus putih (rattus norvegicus). Penelitian ini dilakukan dengan menggunakan 24 ekor tikus jantan yang dibagi 6 kelompok, yaitu kelompok kontrol hari ke-3 (K3),5 (K5), dan 7 (K7) serta kelompok perlakuan gel 100% hari ke-3 (P3), 5 (P5), dan 7 (P7). Variabel penelitian ini adalah jumlah fibroblas dari sediaan HPA dengan pengecatan HE. Analisis menggunakan uji One-Way ANOVA menunjukkan bahwa terdapat pebedaan signifikan jumlah fibroblas antar kelompok. Uji Post-Hoc Multiple Comparison menunjukkan perbedaan signifikan antara K3 dan P3, K5 dan P5, serta P7 dan K7. Hasil rerata menunjukkan kelompok perlakuan hari ke-7 memiliki jumlah fibroblas tertinggi dibandingkan kelompok lain. Kesimpulan pada penelitian ini adalah gel ekstrak daun salam (Syzygium polyanthum) berpengaruh pada penyembuhan luka pasca gingivektomi pada tikus putih (Rattus norvegicus).
English Abstract
Gingival enlargement (Gingival enlargement) is the addition of excessive gingival size. Gingivectomy is one of the surgical phases in periodontal therapy for the elimination of gingival tissue pockets. The bay leaf (syzygium polyanthum) contain active substances, such as saponins, flavonoids, tannins that can accelerate wound healing. The purpose of this research is to know the effect of gel of gel extract form bay leaf (syzygium polyanthumi) on wound healing post gingivectomy in white rat (rattus norvegicus). This research was conducted by using 24 male rats divided into 6 groups, 3-day control groups (K3), 5 (K5) and 7 (K7) and 3-day treatment groups (P3), 5 (P5), and 7 (P7). The variable of this study is the amount of fibroblasts from HPA preparations with HE painting. Analysis using One-Way ANOVA test showed that there were significant differences between the number of fibroblasts between groups. Post-Hoc Multiple Comparison showed that there were significant differences between K3 and P3, K5 and P5, K7 and P7. The mean results showed the treatment group on day 7 had the highest amount of fibroblasts compared to the other groups. The conclusion of this research is gel extract from bay leaves (Syzygium polyanthum) effect on wound healing post gingivectomy in white rat (Rattus norvegicus).
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2018/5/051803043 |
| Uncontrolled Keywords: | Gel ekstrak daun salam (Syzygium polyanthum), fibroblas, gingivektomi |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 76 Drugs derived from specific plants (Lythraceae, Myrtales) |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 08 Jun 2018 01:53 |
| Last Modified: | 21 Oct 2021 04:55 |
| URI: | http://repository.ub.ac.id/id/eprint/11523 |
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