Abousouh, Emad Khalleefah Said (2017) The Eefect Of Thymus Vulgaris Extract On Serum, Il-12 And Bacterial Colonies In Liver Of Mice Infected By Salmonellatyphimurium. Magister thesis, Universitas Brawijaya.
Abstract
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English Abstract
The Thymus vulgaris extracts are effective as antibacterial and immunomodulating agents. Thymol becomes the primary monoterpene phenol which is isomeric with carvacrol and exists in thyme extract. The carvacrol activity is explored in microorganisms which are drug-resistant. Particularly, the strains are significantly pathogenic and difficult to cure up to currently. The intracellular infection of Salmonella stimulates macrophage to produce interleukin IL12 which plays role to stimulate naïve CD4 T cells to differentiate Th1 cells for enhancement of IFN-γ secretion. lFN γ plays important role for activate macrophage as it destroys the phagocytized bacteria. This study aimed to prove the Thymus vulgaris extract increasing IL12 and decreasing bacterial colonies in liver of mice infected with. S.Typhimurium. Thymus vulgaris extracted by maceration 3 times of the all plant (leaves, flowers and branches) which was bought from Nalut-Libya then evaporation of ethanol. The extraction results are stored in freezer. This study used 20 male mice infected Transurethraly by S.Typhimurium and divided into 5 groups, including positive control (infected with S.Typhimurium ), negative control (without infection) and treatment groups D1,D2,D3 (mice administrated with extract of Thymus vulgaris (ECV)250,500,750mg/kgB.wt and with infection) and analyzed by measuring the bacterial colonies in liver, blood levels of IL-12 by ELISA method. Results. Results showed that Thymus vulgaris extract increase serum level IL12, D1,D2 and D3 without infection and decreases in withaPvalue0,000. In same results showed decreases bacterial colonies in liver D1,D2 and D3 with positive control (infected with S.Typhimurium ), Conclusion. Thymus vulgaris extract improve immune response through the increases serum IL-12 and decreases bacterial colonies in liver in mice infected with S. Typhimurium.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/615.321/ABO/t/2017/041710181 |
| Uncontrolled Keywords: | THYMUS EXTRACT, INTERKUKIN - 12, LIVER, SALMONELLA TYPHIMURIUM |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.321 Drugs derived from plants |
| Divisions: | S2/S3 > Magister Ilmu Biomedis, Fakultas Kedokteran |
| Depositing User: | Nur Cholis |
| Date Deposited: | 26 Mar 2018 06:41 |
| Last Modified: | 29 Nov 2021 01:14 |
| URI: | http://repository.ub.ac.id/id/eprint/8954 |
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