Pusparatri, Anisa Putri (2018) Pengaruh Gel Kulit Delima (Punica Granatum L.) Terhadap Jumlah Fibroblas Pada Proses Penyembuhan Ulkus Traumatik Tikus Wistar (Rattus Norvegicus) Yang Diinduksi Panas. Sarjana thesis, Universitas Brawijaya.
Abstract
Ulkus traumatik merupakan lesi yang sering ditemukan di rongga mulut. Pemberian topikal Triamcinolone acetonide 0,1% untuk mengobati ulkus dapat menyebabkan kandidiasis oral. Gel kulit delima (Punica granatum L.) mengandung flavonoid dan tanin yang di dalamnya terdapat ellagic acid yang dapat merangsang proliferasi fibroblas pada proses penyembuhan luka. Jenis penelitian yang digunakan adalah penelitian eksperimental Post Test Only Randomized Control Group Design untuk mengetahui pengaruh gel kulit delima terhadap jumlah fibroblas pada proses penyembuhan ulkus traumatik mukosa labial tikus wistar. Sampel sebanyak 27 tikus wistar dibagi dalam tiga kelompok, yaitu: kelompok kontrol negatif (K-), kelompok kontrol positif (K+), dan kelompok perlakuan (P) dengan tiga time series. Variabel yang diteliti adalah jumlah fibroblas pada jaringan ulkus mukosa labial tikus dihitung dari sediaan HPA dengan pengecatan HE. Hasil penelitian menunjukkan bahwa terjadi peningkatan jumlah fibroblas pada kelompok kontrol negatif (K-), kelompok kontrol positif (K+), dan kelompok perlakuan (P). Hasil penelitian berdasarkan uji One Way ANOVA menunjukkan bahwa jumlah fibroblas antar kelompok berbeda secara signifikan (p<0,05). Rata-rata jumlah fibroblas pada semua kelompok meningkat dari hari ke hari dan kelompok perlakuan memiliki rerata jumlah fibroblas tertinggi yang berbeda secara signifikan dibandingkan kelompok kelompok kontrol negatif dan kelompok kontrol positif (Post Hoc Tukey). Kesimpulan pada penelitian ini yaitu gel kulit delima (Punica granatum L.) mempunyai pengaruh dalam meningkatkan jumlah sel fibroblas pada proses penyembuhan ulkus traumatik mukosa labial tikus wistar (Rattus norvegicus).
English Abstract
Traumatic ulcers are lesions which have the most commonly found in the oral cavity. Topical application Triamcinolone acetonide 0,1% for ulcer treatment can caused oral candidiasis. Pomegrannate peel gel (Punica granatum L.) contains flavonoid and tannin which ellagic acid in, that could stimulates the proliferation of fibroblasts in the wound healing process. This study was an experimental study using Randomized Post Test Only Control Group Design to determine the effect of pomegrannate peel gel to the fibroblast’s number in the healing process of labial mucous traumatic ulcer in wistar rat. 27 wistar rat as sample were divided into three groups: negative control group (K-), positive control gropus (K+), and the treatment group (P) with three time series. Variable that examinated was the number of fibroblast in the oral mucous ulcer tissues that measured from HPA preparation with HE staining. The result based on one way ANOVA test showed that the number of fibroblasts different significantly between the group (p<0.05). the average number of fibroblasts in all groups increased from day to day and the treatment group had the highest average of fibroblasts number which is significantly different than the negative control group and positive control group (Post Hoc Tukey). The conclusion of this research was pomegrannate peel gel (Punica granatum L.) had an effect to increase the fibroblast’s number in the wound healing process of labial mucous traumatic ulcer in wistar rat (Rattus norvegicus).
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2018/6/051803044 |
| Uncontrolled Keywords: | Gel kulit delima (Punica granatum L.), penyembuhan ulkus, fibroblas |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.63 Dental diseases > 617.632 Diseases of gums and tooth sockets / Periodontics > 617.632 06 Periodontics--Treatment / Gingivitis--Treatment > 617.632 061 Periodontics--Chemotherapy |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Sugeng Moelyono |
| Date Deposited: | 08 Jun 2018 01:47 |
| Last Modified: | 21 Oct 2021 04:56 |
| URI: | http://repository.ub.ac.id/id/eprint/11522 |
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