Gatiningrum, Anindita (2018) Efek Pemberian Ekstrak Etanol Akar Gantung Beringin (Ficus benjamina) Terhadap Streptococcus pyogenes Secara In Vitro. Sarjana thesis, Universitas Brawijaya.
Abstract
Streptococcus pyogenes sering menimbulkan peyakit di kulit, mukosa, dan saluran pernapasan dan membutuhkan antibiotik untuk penyembuhannya. Penggunaan antibiotik yang tidak tepat dapat menimbulkan resistensi. Maka dari itu, perlu dicari bahan alternatif dari antibiotik. Akar gantung beringin dapat digunakan karena mengandung senyawa kimia seperti saponin, flavonoid dan polifenol yang dipercaya memiliki efek antibakteri. Penelitian ini menggunakan desain penelitian True Experimental-post test only Control Group Design dan bertujuan untuk mengetahui apakah ekstrak akar gantung beringin dapat menghambat pertumbuhan Streptococcus pyogenes secara in vitro dengan metode difusi sumuran. Hasil yang diperoleh berupa zona hambat yang terbentuk disekitar lubang sumuran dengan konsentrasi 0% sebagai kontrol negatif, 20%, 40%, 60%, 80%, 100%, dan amoxicillin sebagai pembanding. Didapatkan pengukuran diameter terkecil 6,56 mm pada konsentrasi 20% dan diameter teerbesar 14,18 mm pada konsentrasi 100%. Hasil uji statistik One-Way ANOVA menunjukan nilai signifikansi sebesar 0,000 (p< 0,05) yang diperkuat dengan Uji Post Hoc Tukey. Hasil uji korelasi Pearson dan uji regresi menunjukan bahwa semakin besar konsentrasi maka semakin besar zona hambat yang terbentuk.
English Abstract
Streptococcus pyogenes often cause manifestation in the skin, mucosa, and respiratory tract that require antibiotics for its cure. Improper use of antibiotics can lead to resistance. Therefore, it is necessary to look for alternative materials from antibiotics. Banyan hanging roots can be used because they contain chemical compounds such as saponins, flavonoids and polyphenols that are believed to have antibacterial effects. This research uses True Experimentalpost test only Control Group Design design and aims to find out whether the banyan root extract can inhibit the growth of Streptococcus pyogenes in vitro by the diffusion method of wells. The results obtained in the form of drag zone formed around the wellbore with a concentration of 0% as a negative control, 20%, 40%, 60%, 80%, 100%, and amoxicillin as a comparison. The measurement of the smallest diameter 6.56 mm at concentration 20% and the diameter of magnitude 14.18 mm at 100% concentration. One-Way ANOVA statistical test results showed a significance value of 0.000 (p <0.05) reinforced by Post Tukey's Post Hoc Test. Pearson correlation test results and regression tests showed that the greater the concentration the greater the inhibit zone is formed.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2017/575/051803165 |
| Uncontrolled Keywords: | Streptococcus Pyogenes, Akar Gantung Beringin (Ficus Benjamina), Difusi Sumuran |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 45 Drugs derived from spesific plants (Ficus, Moraceae) |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Yusuf Dwi N. |
| Date Deposited: | 13 Apr 2018 09:00 |
| Last Modified: | 26 Oct 2021 03:49 |
| URI: | http://repository.ub.ac.id/id/eprint/9450 |
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