Pengaruh Hidrogel Phytosome Ekstrak Pegagan (Centella Asiatica) Dalam Meningkatkan Ekspresi S100b Pada Tikus Model Traumatic Brain Injury (Tbi)

Nugroho, Wahyu Dwi (2017) Pengaruh Hidrogel Phytosome Ekstrak Pegagan (Centella Asiatica) Dalam Meningkatkan Ekspresi S100b Pada Tikus Model Traumatic Brain Injury (Tbi). Sarjana thesis, Universitas Brawijaya.

Abstract

Traumatic Brain Injury (TBI) adalah cedera struktural pada otak atau gangguan fisiologis fungsi otak akibat trauma. Ekstrak Pegagan mempunyai kandungan aktif Asiatikosida yang mampu meningkatkan transkripsi S100B yang berperan dalam perbaikan fungsi kognitif dan memori. Hidrogel fitosom merupakan drug delivery systems untuk memperbaiki farmakokinetik bahan aktif suatu zat. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian hidrogel fitosom ekstrak pegagan pada tikus model TBI terhadap peningkatan ekspresi S100B. Desain penelitian ini menggunakan desain eksperimen murni (true experimental design) dengan rancangan randomized post test only controlled group design yang menggunakan enam belas kelompok tikus Sprague dawley jantan yang masing-masing terdiri dari tiga sampel. Variabel yang diukur adalah S100B yang dilihat secara mikroskopis dengan pengecatan imunohistokimia. Berdasarkan hasil tes ANOVA, menunjukkan bahwa hidrogel fitosom ekstrak pegagan memperbaiki sel-sel saraf melalui aktivasi S100B secara signifikan (p<0,05). Dari hasil analisis data, dapat disimpulkan bahwa pemberian hidrogel fitosom ekstrak pegagan mampu meningkatkan ekspresi S100B pada tikus model traumatic brain injury (TBI).

English Abstract

Traumatic Brain Injury (TBI) is a structural injury to the brain or a physiological disorder of brain function due to trauma. Pegagan extract has an active component Asiaticoside which can improve S100B transcription that plays a role in the improvement of cognitive and memory functions. Phytosome is a drug delivery system for improving the pharmacokinetics of an active substance. This study is aimed to determine the effects of giving phytosome hydrogel of pegagan extract on rats model TBI to increase the expression of S100B. This study was using pure experimental design with randomized post-test only controlled group design using sixteen groups of Sprague dawley rats, each group consists three samples. The measured variable is S100B, which was seen by microscope with imunohistochemical imaging. According to ANOVA test results, it was showed that phytosome hydrogel improved the nerve cells through the activation of S100B significantly (p <0.05). From result of data analysis, it can be concluded that giving phytosome hydrogel of pegagan extract (Centella asiatica) can increase expression of S100B in rat model of traumatic brain injury (TBI).

Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2017/513/051800883
Uncontrolled Keywords: Traumatic Brain Injury , Hidrogel fitosom, Ekstrak pegagan (Centella asiatica), S100B, Traumatic Brain Injury, Hidrogel Phytosome, Pegagan Extract (Centella asiatica), S100B.
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.7 Pharmacokinetics > 615.78 Drugs affecting nervous system
Divisions: Fakultas Kedokteran > Pendidikan Dokter
Depositing User: Nur Cholis
Date Deposited: 25 Jan 2018 07:12
Last Modified: 26 Oct 2021 03:17
URI: http://repository.ub.ac.id/id/eprint/8419
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