Kurniati, - (2017) Pengaruh Terapi Salep Daun Singkong (Manihot esculenta) terhadap Luka Bakar pada Tikus Putih berdasarkan Kadar Enzim SOD dan Re-epitelisasi Histopatologi Kulit. Sarjana thesis, Universitas Brawijaya.
Abstract
Luka bakar merupakan salah satu masalah kesehatan non infeksius yang menyebabkan kerusakan jaringan epitel kulit, sehingga rentan terhadap infeksi dan menghambat proses penyembuhan luka. Daun singkong (Manihot esculenta) dapat dijadikan sebagai salah satu alternatif pengobatan luka bakar yang mengandung beberapa komponen yang berpotensi mempercepat re-epitelisasi, seperti flavonoid dan saponin berperan sebagai antiinflamasi dan antibakteri; tanin dan triterpenoid berperan sebagai antioksidan; dan vitamin C. Penelitian ini bertujuan untuk mengetahui pengaruh terapi salep daun singkong terhadap luka bakar derajat II pada tikus putih berdasarkan kadar enzim SOD dan re-epitelisasi histopatologi kulit. Penelitian ini bersifat eksperimental menggunakan RAL dengan lima kelompok perlakuan yaitu kontrol negatif (tikus sehat), kontrol positif (diinduksi luka bakar tanpa pemberian terapi) dan tiga kelompok terapi (diinduksi luka bakar dengan pemberian terapi salep daun singkong konsentrasi bertingkat 4%, 8% dan 12% selama 14 hari). Pengukuran kadar enzim SOD menggunakan metode spektrofotometri kemudian data dianalisis menggunakan uji One-Way ANOVA dengan taraf kepercayaan 95% dan pengamatan histopatologi kulit dengan pewarnaan Hematoxylin-Eosin perbesaran 100x. Hasil penelitian menunjukkan percepatan re-epitelisasi pada kelompok terapi dilihat dari kadar enzim SOD dan histopatologi kulit terutama pada kelompok terapi 12%. Kesimpulan penelitian ini yaitu terapi luka bakar menggunakan salep daun singkong mampu mempercepat re-epitelisasi.
English Abstract
Burn injuries are one of the noninfectious health problems that cause damage to the epithelial tissue of the skin, making it susceptible to infection and inhibiting wound healing. Cassava leaves (Manihot esculenta) can be used as an alternative treatment of burn injuries that contain several components that potentially accelerate re-epithelization, such as flavonoids and saponins act as anti-inflammatory and antibacterial; tannins and triterpenoids act as antioxidants; and vitamin C. This study aims to determine the effect of cassava leaves ointment therapy on grade II burn injuries in white rats based on SOD enzyme levels and skin histopathology re-epithelization. This study was experimental using RAL with five treatment groups: negative control (healthy rats), positive control (induced burn without therapy) and three treatment groups (induced burns with 4%, 8% 12% for 14 days). Measurement of SOD enzyme level using spectrophotometric method then data was analyzed using One-Way ANOVA test with 95% confidence level and skin histopathology observation with 100x Hematoxylin-Eosin magnification. The results showed accelerated re-epithelialization in the therapy groups seen from the levels of SOD enzymes and histopathology of the skin, especially in the 12% therapy group. The conclusion of this research is that burn injuries therapy using cassava leaves ointment can accelerate re-epithelization.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2017/196/051712380 |
| Uncontrolled Keywords: | Luka bakar, Kulit, Daun singkong, SOD, Histopatologi, Burns, Skin, Cassava leaves, SOD, Histopathology. |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.1 Injuries and wounds > 617.11 Burns and scalds > 617.110 6 Burns and scalds--Treatment |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 22 Dec 2017 03:00 |
| Last Modified: | 20 Jan 2022 07:31 |
| URI: | http://repository.ub.ac.id/id/eprint/7476 |
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