Pengaruh Lendir Bekicot (Achatina Fulica) Terhadap Jumlah Limfosit Pada Proses Penyembuhan Luka Soket Gigi Pasca Pencabutan Gigi Tikus Wistar (Rattus Norvegicus)

Riyani, Nadya Jeihan (2017) Pengaruh Lendir Bekicot (Achatina Fulica) Terhadap Jumlah Limfosit Pada Proses Penyembuhan Luka Soket Gigi Pasca Pencabutan Gigi Tikus Wistar (Rattus Norvegicus). Sarjana thesis, Universitas Brawijaya.

Abstract

Pencabutan gigi merupakan suatu tindakan pengambilan gigi dari dalam soket pada tulang alveolar yang dapat menyebabkan kesatuan dari jaringan lunak dan jaringan keras gigi dalam rongga mulut mengalami kerusakan. Peradangan merupakan respon dasar terhadap adanya kerusakan jaringan atau luka pasca pencabutan gigi yang kemudian dilanjutkan dengan proses penyembuhan. Lendir bekicot dari spesies Achatina fulica diketahui mengandung protein achasin dan glycosaminoglycan yang berupa heparan sulfate sebagai alternatif obat yang mempercepat proses penyembuhan luka. Heparan sulfat diketahui memiliki fungsi sebagai pengikat dan penyimpanan bagi faktor pertumbuhan juga berperan dalam merangsang rekrutmen limfosit dan sel radang ke daerah luka sesaat setelah terjadi perlukaan, sehingga fase inflamasi berlangsung lebih singkat. Jenis penelitian yang digunakan adalah eksperimental laboratoris dengan desain penelitian Randomized Post-Test Only Control Group. Sampel dipilih menggunakan teknik Simple Random Sampling kemudian dibagi ke dalam dua kelompok, yaitu kelompok kontrol (K) dan perlakuan (P). Variabel yang diteliti pada penelitian ini adalah jumlah limfosit pada hari ketiga, kelima, dan ketujuh proses penyembuhan luka soket gigi tikus wistar yang diukur dari sediaan HPA dengan pengecata Hematoxylin-Eosin. Hasil penelitian menunjukan adanya perbedaan jumlah limfosit pada hari ketiga, kelima, dan ketujuh baik pada kelompok kontrol (K) maupun perlakuan (P). Kesimpulan pada penelitian ini adalah lendir bekicot (Achatina fulica) berpengaruh pada jumlah limfosit pada proses penyembuhan luka soket gigi tikus wistar (Rattus norvegicus).

English Abstract

Tooth extraction is a process of taking tooth from its socket in the alveolar bone which can lead the injury of soft tissue and hard tissue in oral cavity. Inflammation is a basic response to tissue injury or wound after tooth extraction which followed by the healing process. Snail slime from Achatina fulica species contain of achasin and glycosaminoglycan which known as an alternative medicine that can accelerates the wound healing process. Heparan sulfate that can be found in Achatina fullica’s slime is known to have function as a binder and storage for growth factors, it’s also play role in stimulating the recruitment of lymphocytes and other inflammatory cells into the wound area shortly after the injury that can make the inflammatory phase lasts shorter. The type of this study was experimental laboratory research and using Post Test Only Group Design. Samples were selected using simple random sampling technique then divided into two groups: control (K) and treatment (P). Variables examined in this study is the number of lymphocytes in the third, fifth, and seventh day in tooth socket healing process on wistar rats were measured from HPA preparations with Hematoxylin-Eosin staining. The results showed a significant differences in the number of lymphocytes on the third, fifth, and seventh day in tooth socket healing process both in the control group (K) and treatment (P). The conclusion of this research is snail slime (Achatina fulica) has effect on the number of lymphocytes in the tooth socket healing process post white rats (Rattus norvegicus) tooth extraction.

Item Type: Thesis (Sarjana)
Identification Number: SKR/FKG/2017/60/051704259
Uncontrolled Keywords: Pencabutan Gigi, Lendir Bekicot (Achatina fulica), Heparan Sulfat, Penyembuhan Luka, Limfosit
Subjects: 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.63 Dental diseases > 617.632 Diseases of gums and tooth sockets / Periodontics
Divisions: Fakultas Kedokteran Gigi > Kedokteran Gigi
Depositing User: Kustati
Date Deposited: 03 Oct 2017 02:48
Last Modified: 30 Sep 2020 07:25
URI: http://repository.ub.ac.id/id/eprint/3147
[thumbnail of Riyani, Nadya Jeihan.pdf] Text
Riyani, Nadya Jeihan.pdf

Download (3MB)
[thumbnail of Thumbnails conversion from text to thumbnail_lightbox] Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg

Download (69kB)
[thumbnail of Thumbnails conversion from text to thumbnail_preview] Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg

Download (25kB)
[thumbnail of Thumbnails conversion from text to thumbnail_medium] Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg

Download (7kB)
[thumbnail of Thumbnails conversion from text to thumbnail_small] Other (Thumbnails conversion from text to thumbnail_small)
small.jpg

Download (2kB)

Actions (login required)

View Item View Item