Saveria, Irene (2017) Pengaruh Suplementasi Curcuma Xanthorriza Pada Pasien Lupus Eritematosus Sistemik (Les) Dengan Hipovitamin D Yang Diberikan Vitamin D3 Terhadap Derajat Kelelahan (Fatigue), Kadar Il-6 Dan Tgf–Β1 Serum. Magister thesis, Universitas Brawijaya.
Abstract
PPDS I Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Brawijaya, Rumah Sakit Umum Daerah dr. Saiful Anwar Malang 2 Divisi Reumatologi dan Alergi Imunologi, Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Brawijaya Malang, Rumah Sakit Umum Daerah dr. Saiful Anwar Malang Tujuan: Bagaimana pengaruh penambahan Curcuma xanthorriza pada pemberian vitamin D3 terhadap derajat kelelahan (fatigue) serta perubahan kadar sitokin IL-6 dan TGF-β1 pada pasien LES dengan hipovitamin D. Metode : Penelitian randomized double blind controlled trial pada 40 pasien LES yang rutin berobat di Poli Reumatologi RS Dr. Saiful Anwar Malang, 20 sampel mendapat softgel vitamin D3/Cholecalciferol 1200 IU/hari dan plasebo sedangkan 20 lainnya mendapat softgel vitamin D3/Cholecalciferol 1200 IU/hari dan tablet Curcuma xanthoriza 60mg/hari selama 3 bulan. Variabel yang dianalisis sebelum dan sesudah suplementasi adalah nilai FSS (Fatigue Severity Scale) dan VAS-F (Visual Analogue Scale-Fatigue), kadar vitamin D/ 25(OH)D diukur dalam serum dengan metoda Enzyme Immuno Assay dari DiaSorin dengan satuan ng/ml, kadar IL-6 dan TGF-β1 serum yang diukur dengan metode ELISA dari Biolegend dengan satuan pg/ml. Hasil: Pasien yang memenuhi kriteria inklusi dan eksklusi untuk kelompok plasebo adalah 20 orang dan kelompok Curcuma xanthorriza adalah 19 orang dimana 1 pasien dari kelompok Curcuma xanthorriza dropout karena ketidakpatuhan berobat. Terdapat peningkatan signifikan kadar vitamin D pada kedua kelompok tetapi tidak berbeda bermakna antara delta keduanya (p=0.166). Kadar vitamin D setelah suplementasi berbeda bermakna pada kelompok plasebo dibandingkan kelompok Curcuma xanthorriza (p=0.047*). Nilai FSS menurun signifikan tetapi tidak berbeda bermakna antara delta keduanya (p=0.300). Nilai VAS-F menurun signifikan pada kedua kelompok tetapi tidak berbeda bermakna antara delta keduanya (p=0.085). Kadar IL-6 menurun signifikan pada kedua kelompok tetapi tidak berbeda bermakna antara delta keduanya (p=0.061). Kadar TGF-β1 meningkat signifikan tetapi tidak berbeda bermakna antara delta keduanya (p=0.535). Terapat korelasi positif antara nilai FSS dan VAS-F dengan (p=0.001*, r=0.571), tetapi tidak didapatkan korelasi antara fatigue dengan IL-6 dan TGF-β1 serum. Kesimpulan: Pemberian Curcuma xanthorriza pada pemberian vitamin D3 bagi pasien LES yang hipovitamin D tidak berbeda bermakna dalam menurunkan derajat fatigue, menurunkan kadar IL-6, TGF-β1 serum dibandingkan pemberian vitamin D3 saja.
English Abstract
1 Resident of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital, Malang 2 Rheumatology, Allergy and Immunology Division, Internal Medicine Department, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital, Malang Introduction: The aim of this study is to determine effect supplementation of Curcuma xanthorriza in giving of vitamin D3 to fatigue and change of IL-6 and TGF β1 serum in LES patient with hypovitaminosis D. Methods: A double blind randomized controlled trial, with 40 subjects. Subjects were SLE outpatient clinic in rheumatology clinic Saiful Anwar hospital that suffered from hypovitaminosis D (vitamin D<30 ng/ml). From 40 Patients we divided into 2 groups, each group 20 patients with simple randomization. First group will receive softgel vitamin D3/cholecalciferol 1200 IU/day and placebo and the other 20 patients will receive softgel vitamin D3/cholecalciferol 1200 IU/day and Curcuma xanthorriza tablet 60 mg/days, study was conducted for 3 months. Variable that will be analyzed before and after experiment were fatigue, measured by Fatigue Severity Scale (FSS) and Visual Analogue Scale-Fatigue (VAS-F). Vitamin D/ 25(OH)D serum is measured by Enzyme Immuno Assay from DiaSorin with units of measurement is ng/ml, IL-6 dan TGF-β1 serum is measured by ELISA method from Biolegend with units of measurement is pg/ml. Results: Patient that meet the inclusion and exclusion criteria and follow the study until finish in placebo group was 20 patient and in Curcuma xanthorriza group was 19 patient,1 patient was dropout from the study because low of compliance. There was significant increase of vitamin D and significant decrease of FSS score and VAS-F score in both group compared before and after study but there was no significant difference between delta of these group (p= 0.166), FSS, (p=0.300), VAS-F (p=0.085). Vitamin D level post treatment increase significant in placebo group rather than in Curcuma xanthorriza group (p=0.047*). Decrease of IL-6 significant before and after study in both groups but if we compare each other there was no significant difference (p=0.061). There also no significant difference between increase of TGF-β1 in each group (p=0.535). We found positive correlation between FSS and VAS-F score (r=0.571, p=0.001*) but we couldn’t found correlation between fatigue and IL-6 and TGF-β1 serum. Conclusion: Supplementation of Curcuma xanthorriza and vitamin D3 in SLE patient with hypovitaminosis D was not significantly differ compared to vitamin D3 only in decrease fatigue, decrease IL-6 and increase TGF-β1 serum.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/615.324 39/SAV/p/2017/041704826 |
| Uncontrolled Keywords: | CURCUNA, LUPUS ERYTHEMATOSUS, VITAMIN D, INTERLEUKIN-6, TRANSFORMING GROWTH FACTOR, FATIQUE |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.324 39 Drugs derived from specific plants (Ginger, Musaceae, Zingiberales) |
| Divisions: | S2/S3 > Magister Ilmu Biomedis, Fakultas Kedokteran |
| Depositing User: | Nur Cholis |
| Date Deposited: | 17 Jul 2017 02:26 |
| Last Modified: | 29 Dec 2020 04:21 |
| URI: | http://repository.ub.ac.id/id/eprint/265 |
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