Effendi, dr. Tiar Oktavian and dr. Iin Noor Chozin,, Sp.P(K) and dr. Suryanti Dwi Pratiwi,, Sp.P(K) and Prof. Drs. Arinto Yudi Ponco Wardoyo,, M.Sc, Ph.D and Dr. dr. Nanik Setijowati,, M.Kes (2022) Analisis Kadar Volatile Organic Compounds (VOC) pada Penderita COVID-19 Berdasarkan Derajat Keparahan Penyakit. Magister thesis, Universitas Brawijaya.
Abstract
Latar belakang : Lebih dari 2 tahun sejak pertama kali kasus COVID-19 dilaporkan di tahun 2019. Diagnosis dari COVID-19 merupakan kunci utama dalam mengontrol pandemi yang terjadi. Sampel yang digunakan untuk pemeriksaan COVID-19 umumnya diambil dari prosedur swab naso-oro-faring. Prosedur ini seringkali menimbulkan rasa tidak nyaman dan memerlukan pemeriksan yang terlatih. Udara ekspirasi pernapasan mengandung ribuan volatile organic compounds (VOC) yang mungkin dapat berubah selama proses infeksi. Penelitian ini bertujuan untuk menganalisa perbedaan kadar VOC pada udara pernapasan penderita COVID-19 dengan kelompok kontrol, serta menganalisa hubunngan kadar VOC dengan derajat keparahan COVID-19. Metode : Penelitian cross-sectional dilakukan dengan total 90 subjek terkonfirmasi COVID-19 dan 42 subjek kontrol. Sampel udara pernapasan ditampung dalam 500 ml kantong udara pada kedua kelompok. Sampel kemudian dianalisa menggunakan breath analyzer untuk menilai konsentrasi dari kadar CO2, C7H8, C6H14, CH2O, NH4, TVOC, NO2, PM1.0, CO, NH3 dan Acetone. Hasil : Median dari CO2, C6H14, NH4, TVOC, NO2, dan Acetone ditemukan secara signifikan lebih rendah pada kelompok COVID-19 (secara berurutan 607,3 vs 1175,1; 0,0 vs 0,47; 0,0 vs 1,05; 0,05 vs 146,6; 0,04 vs 1,55; 0,0 vs 0,23) sedangkan C7H8, CH2O, CO, and NH3 secara signfikan lebih tinggi (secara berurutan 0,92 vs 0,0; 0,55 vs 0,01; 0,24 vs 0,0; 1,99 vs 0,67). Analisa lebih lanjut menunjukkan kadar NH4, Acetone, NH3, dan CO berkorelasi positif dengan derajat keparahan COVID-19, sedangkan CO2 dan TVOC berkorelasi negatif. Kesimpulan : Kadar VOC yang ditemukan pada penderita COVID-19 berbeda dengan kelompok kontrol, dan berkorelasi dengan derajat keparahan penyakit.
English Abstract
Background: More than 2 years since COVID-19’s first cases were reported in 2019. Diagnosis of COVID-19 is a key to controlling the pandemic. Sample for COVID-19 testing is collected by naso-oro-pharyngeal swab. This procedure is often uncomfortable and requires a trained examiner. Exhaled breath contains thousands of volatile organic compounds (VOC) which are likely to change during infection. This study aims to analyze the difference of VOC in the exhaled breath between COVID-19 and healthy subjects. Methods: A cross-sectional study was carried out recruiting 90 confirmed cases of COVID-19 and 42 healthy subjects. A sample of exhaled breath was collected by using a 500 ml airbag in both groups. Sample was analyzed using an arrayed sensor breath analyzer to quantify the concentration of CO2, C7H8, C6H14, CH2O, NH4, TVOC, NO2, PM1.0, CO, NH3 and Acetone. Results: The median of CO2, C6H14, NH4, TVOC, NO2, and Acetone are significantly lower in COVID-19 patients compared to healthy subjects (respectively 607.3 vs 1175.1; 0.0 vs 0.47; 0.0 vs 1.05; 0.05 vs 146.6; 0.04 vs 1.55; 0.0 vs 0.23) while C7H8, CH2O, CO, and NH3 are significantly higher (respectively 0.92 vs 0.0; 0.55 vs 0.01; 0.24 vs 0.0; 1.99 vs 0.67; all with p-value of <0.05.). Furthermore, we found NH4, Acetone, NH3, and CO are positively correlate with severity of COVID-19, while CO2 and TVOC are negatively correlate. Conclusions: COVID-19 patients emit distinctive VOC profiles in comparison with healthy subjects, and it is related to the severity of the disease.
Other obstract
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| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | 0422060185 |
| Uncontrolled Keywords: | Volatile organic compounds, VOC, COVID-19, Diagnosa COVID-19 |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system > 616.24 Diseases of Lungs / Lungs--Diseases |
| Divisions: | Profesi Kedokteran > Spesialis Pulmonologi dan Kedokteran Respirasi, Fakultas Kedokteran |
| Depositing User: | Endang Susworini |
| Date Deposited: | 10 May 2023 01:32 |
| Last Modified: | 10 May 2023 01:32 |
| URI: | http://repository.ub.ac.id/id/eprint/199167 |
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