Wulandari, Catur and Dr. dr. Shahdevi Nandar K,, Sp.S (K) and dr. Rodhiyan Rakhmatiar,, Sp.S and dr. Rulli Rosandi,, Sp.PD and Dr. dr. Siswanto,, M.Sc (2018) Uji Diagnostik Quantitative Sensory Testing (Qst) Untuk Mengidentifikasi Polineuropati Pada Pasien Diabetes Melitus Tipe 2. Magister thesis, Universitas Brawijaya.
Abstract
Latar Belakang: Neuropati diabetes merupakan komplikasi diabetes yang serius dan paling sering terjadi. Polineuropati DM merupakan bentuk yang paling banyak ditemukan pada neuropati diabetes (sekitar 75%). Pemeriksaan ENMG cukup mahal, tidak banyak tersedia, dan memerlukan tenaga ahli khusus. Penelitian ini mengevaluasi nilai diagnostik Quantitative Sensory Testing Vibration Perception Threshold (VPT), Warm Perception Threshold (WPT), dan Cold Perception Threshold (CPT) untuk mengidentifikasi polineuropati pada pasien DM tipe 2. Metode: Penelitian cross sectional ini dilaksanakan di poliklinik endokrin RSUD dr. Saiful Anwar (RSSA) Malang sejak Maret hingga Oktober 2018. Total 113 subyek memenuhi kriteria inklusi dan tidak didapatkan kriteria ekslusi diperiksa pada penelitian ini. Seluruh subyek penelitian dilakukan pemeriksaan VPT, WPT, dan CPT yang dibandingkan dengan kriteria polineuropati DM menurut American Academy of Neurology (AAN). Hasil: Prevalensi polineuropati DM menurut kriteria AAN adalah 80%. Nilai sensitivitas VPT sebesar 83% dan spesifisitas 39%. Sensitivitas WPT sebesar 83% dengan spesifisitas 52%. Sensitivitas CPT sebesar 88% dan spesifisitas 52%. Sensitivitas kombinasi VPT dan CPT sebesar 93% dan spesifisitas 26%. Nilai sensitivitas kombinasi VPT dan WPT sebesar 92% dan spesifisitas 26%. Sensitivitas kombinasi WPT dan CPT sebesar 89% dan spesifisitas 52%. Nilai sensitivitas kombinasi VPT, WPT dan CPT sebesar 94% dan spesifisitas 26%. Kesimpulan: Tes kuantitas sensoris VPT, WPT, dan CPT memiliki sensitivitas serta akurasi yang baik dalam mendeteksi polineuropati DM. Idealnya dilakukan evaluasi pada ketiga modalitas (VPT, WPT, dan CPT) dalam mendeteksi polineuropati DM. Pada kondisi yang tidak memungkinkan dilakukan ketiga modalitas, pemeriksaan CPT atau kombinasi WPT dan CPT dapat dipertimbangkan sebagai pemeriksaan yang dipilih
English Abstract
Background: Diabetic neuropathy is serious and the most common complication of diabetes. Diabetic polyneuropathy is the most common type of diabetic neuropathy (75%). Electroneuromyography is expensive, not widely available, and requires special expert. This study evaluates diagnostic feature of Quantitative Sensory Testing Vibration Perception Threshold (VPT), Warm Perception Threshold (WPT), and Cold Perception Threshold (CPT) to identify polyneuropathy on type 2 diabetes mellitus. Methods: This cross sectional study was conducted in endocrine outpatient department Saiful Anwar General Hospital Malang since March to October 2018. A total of 113 subjects who were met inclusion criteria and didn’t have any exclusion criteria were included in this study. The data of VPT, WPT, and CPT from all subjects were obtained and compared with polyneuropathy criteria from American Academy of Neurology (AAN). Result: VPT displayed sensitivity 83%, specificity 39%, and accuracy 74%. WPT displayed sensitivity 83%, specificity 52% and accuracy 77%. CPT displayed sensitivity 88%, specificity 52% and accuracy 81%. Combination VPT and CPT displayed sensitivity 93%, specificity 26% and accuracy 80%. Combination VPT and WPT displayed sensitivity 92%, specificity 26% and accuracy 79%. Combination WPT and CPT displayed sensitivity 89%, specificity 52% and accuracy 81%. Combination VPT, WPT and CPT displayed sensitivity 94%, specificity 26% and accuracy 81%. Conclusion: QST VPT, WPT, and CPT have good sensitivity and accuracy to detect diabetic polyneuropathy. Ideally all of three modalities were evaluate to detect diabetic polyneuropathy. If a full evaluation wasn’t possible we can consider CPT or combination of WPT and CPT as a choice.
| Item Type: | Thesis (Magister) |
|---|---|
| Identification Number: | TES/616.462 4/WUL/u/2018/041901089 |
| Uncontrolled Keywords: | Polineuropati DM, VPT, WPT, CPT,Diabetic polyneuropathy, VPT, WPT, CPT |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.8 Diseases of nervous system and mental disorders |
| Divisions: | Profesi Kedokteran > Spesialis Neurologi, Fakultas Kedokteran |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 03 Oct 2022 08:09 |
| Last Modified: | 03 Oct 2022 08:09 |
| URI: | http://repository.ub.ac.id/id/eprint/195286 |
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