Pengaruh Pemberian Platelet Rich Plasma Pada Tindakan Micrografting Terhadap Proses Epitelisasi

Viona, Regine (2016) Pengaruh Pemberian Platelet Rich Plasma Pada Tindakan Micrografting Terhadap Proses Epitelisasi. Magister thesis, Universitas Brawijaya.

Abstract

Latar Belakang: Proses penyembuhan luka bakar saat ini menjadi kajian utama . Beban kesakitan dan kecacatan mendorong penanganan luka bakar yang lebih efektif, salah satunya dengan tindakan micrografting. Penggunaan Platelet Rich Plasma (PRP) pada tindakan micrografting mengoptimalkan penyembuhan luka bakar. Metode: Penelitian ini merupakan penelitian eksperimental klinis post test only control group. Pada 9 pasien luka bakar yang dilakukan tindakan micrografting diberikan 2 macam perlakuan, pada separuh luasan diberikan PRP dan pada separuh luasan lainnya tidak diberikan PRP. Penilaian epitelisasi diukur dengan secara histologi: makrofag, fibroblas dan kolagen; secara klinis berupa kategori dan graft take. Hasil: Terdapat peningkatan rerata makrofag (dengan PRP sebesar 11,222 dan NON PRP sebesar 4,111), fibroblas (kelompok PRP sebesar 16,444 dan NON PRP sebesar 6,556) dan kolagen (kelompok PRP sebesar 6,778 dan NON PRP sebesar 1,994) dengan p<0,05. Pada variabel klinis pengamatan hari ke 5 diperoleh nilai Wilcoxon sebesar -2,236 (p=0,025) sedangkan pengamatan hari ke 10 diperoleh nilai Wilcoxon sebesar -2,000 (p=0,046). Didapatkan juga peningkatan rerata graft take pada kelompok PRP sebesar 82,222 dan NON PRP sebesar 72,778 (p=0,001). Pemberian PRP pada tindakan micrografting menunjukkan perbedaan yang signifikan secara histologi dan klinis. Kesimpulan: Pemberian Platelet Rich Plasma dapat mengoptimalkan proses penyembuhan luka melalui peningkatan makrofag, fibroblas, kolagen yang mempercepat terjadinya epitelisasi.

English Abstract

Objectives: Wound healing process especially for burn injury had been talked about recently, pain burden and disability of burn injury encouraged for an effective treatment, one of the treatment include micrografting. The application of Platelet Rich Plasma on micrografting are able to speed up wound healing in burn injury. Methods: This study is a clinical experimental study, post test only control group. Nine patients with burn injury who underwent micrografting are treated in two different manner, first half of total area covered with micrografting are given platelet rich plasma, while the other half are left as it is. Epithelization are measured histologically by the appearance of macrophage, fibroblast and collagen; clinically and graft take. Results: Significant increased p<0,05 on histology appearance; macrophage in platelet rich plasma group are 11.222 and 4,111 in non platelet rich plasma group; fibroblast in platelet rich plasma group are 16,444 and 6,556 in non platelet rich plasma group respectively; and collagen in platelet rich plasma group account for 6,778 and 1,994 in non platelet rich plasma group. The result on clinical evaluation on the 5th and 10th days are -2,236 (p=0,025) and- 2,000 (p=0,046) respectively. Graft take are also increasing significantly in platelet rich plasma group with 82,222 and non platelet rich plasma group 72,778 (p=0.001). The application of Platelet Rich Plasma on micrografting demonstrated a significant difference on histologically and clinically. Conclusion: Platelet rich plasma are efficacious towards wound healing process through increasing of macrophage, fibroblast and collagen that can speed up epithelization.

Other obstract

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Item Type: Thesis (Magister)
Identification Number: TES/615.39/VIO/p/2016/041811546
Uncontrolled Keywords: micrografting, platelet rich plasma, makrofag, fibroblas, kolagen, epitelisasi, graft take
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.39 Human blood products and their substitutes
Divisions: Profesi Kedokteran > Spesialis Ilmu Bedah, Fakultas Kedokteran
Depositing User: Endang Susworini
Date Deposited: 18 Jul 2022 03:13
Last Modified: 18 Jul 2022 03:13
URI: http://repository.ub.ac.id/id/eprint/192160
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