Systematic Literature Review: Metode Preparasi dan Rasio Komponen Chitosan dalam Microneedle Patch untuk Transdermal Delivery System

Widyastuti, Ajeng (2021) Systematic Literature Review: Metode Preparasi dan Rasio Komponen Chitosan dalam Microneedle Patch untuk Transdermal Delivery System. Sarjana thesis, Universitas Brawijaya.

Abstract

Sistem penghantaran obat transdermal merupakan sistem penghantaran obat yang potensial untuk pemberian obat lokal dan sistemik. Namun, masih ada beberapa keterbatasan dalam system ini, terutama terkait dengan kebutuhan untuk meningkatkan penetrasi obat melalui kulit. Oleh karena itu, mekanisme penghantaran obat baru berdasarkan microneedle telah dikembangkan. Microneedles dianggap sebagai jawaban atas masalah metode sebelumnya, yaitu banyaknya obat yang tidak dapat menembus kulit untuk mencapai efek terapeutik. Microneedles biodegradable, terutama kitosan, dipilih sebagai bahan penyusun karena memiliki karakteristik biodegradabilitas, biokompatibilitas, tidak beracun, polikationik, dan aktivitas antibakteri. Namun metode dan perbandingan komponen kitosan dalam pembuatan microneedle patch belum banyak diketahui. Penelitian ini bertujuan untuk menentukan metode preparasi dan rasio komponen kitosan dalam microneedle patch untuk sistem penghantaran obat transdermal. Penelitian deskriptif menggunakan metode review artikel tersturuktur dilakukan pada tiga database digital: Google Scholar, Scopus, dan Crossref. 16 artikel dipilih sebagai sampel setelah proses seleksi dan critical appraisal dilakukan. Hasil sintesis dari 16 artikel akhir terpilih didapatkan bahwa micromolding menggunakan polydimethylsiloxane (PDMS) merupakan metode yang paling banyak digunakan untuk fabrikasi microneedle kitosan karena memungkinkan replikasi microneedle yang tepat dan akurat sesuai dengan spesifikasi tinggi dan diameter yang diinginkan serta memungkinkan produksi secara massal. Rasio komponen kitosan yang paling banyak digunakan adalah larutan kitosan 2% (b/v) dimana serbuk kitosan dilarutkan dalam larutan asam asetat 1% (v/v). Microneedle kitosan 2% memiliki kekuatan mekanik yang lebih rendah dibandingkan konsentrasi lainnya. Namun dengan kekuatan mekanik yang lebih rendah, microneedle kitosan 2% tetap dapat disisipkan ke dalam kulit. Kesimpulannya microneedles dapat dibuat dari kitosan umumnya dengan teknik micro-molding menggunakan PDMS dengan kitosan 2%. Berdasarkan penelitian ini, disarankan bagi penelitian lebih lanjut perlu ditambahkan jumlah sampel dan lama waktu penelitian serta menghubungkan efek sifat zat aktif dan komponen yang terkait metode preparasi terhadap karakteristik microneedle kitosan.

English Abstract

The transdermal drug delivery system is a potential delivery system for local and systemic drug administration by delivering compounds through the skin into the body. However, there are still some limitations, primarily related to the need to improve drug penetration through the skin. For this, new drug delivery mechanisms based on microneedles have been developed. Microneedles are considered the answer to the problem of previous methods, namely that many drugs are unable to penetrate the skin to achieve a therapeutic effect. Biodegradable microneedles, especially chitosan, were chosen as the basic material because of their recognized biodegradability, biocompatibility, nontoxic, polycationic, and antibacterial activity. However, the method and ratio of chitosan components in the production of microneedle patch are not widely known. This research was aimed to determine the preparation method and ratio of chitosan components in microneedle patches for transdermal delivery systems. Descriptive research using systematic literature review methods was performed on three digital databases: Google Scholar, Scopus, and Crossref. 16 articles were chosen as sample after the selection process and critical appraisal was conducted. The synthesis result of the 16 selected final articles found that micro molding using polydimethylsiloxane (PDMS) is the most widely used method for chitosan microneedle fabrication because it allows precise and accurate replication of microneedles according to the desired height and diameter specifications and can be mass-produced. The most widely used chitosan component ratio is 2% (w/v) chitosan solution in which chitosan powder is dissolved in 1% (v/v) acetic acid solution. Microneedle of 2% chitosan has lower mechanical strength than other concentrations. However, with lower mechanical strength, a microneedle of 2% chitosan can still be successfully inserted into the skin. In conclusion, microneedles can be fabricated from chitosan generally by micro-molding using PDMS with 2% chitosan. Based on this research, it is suggested that for further research, it is necessary to add the number of samples and the length of time of the study as well as to connect the effects related to the active substance and the components of the preparation method to the characteristics of chitosan microneedle

Item Type: Thesis (Sarjana)
Identification Number: 0521060295
Uncontrolled Keywords: Kitosan, microneedle patch, formulasi, Chitosan, microneedle patch, formulation
Subjects: 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica)
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 02 Feb 2022 07:29
Last Modified: 23 Feb 2022 07:51
URI: http://repository.ub.ac.id/id/eprint/189173
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