N. Kurnianingsih, - Purple Sweet Potatoes from East Java of Indonesia Revealed the Macronutrient, Anthocyanin Compound and Antidepressant Activity Candidate.
Abstract
Purple Sweet Potatoes from East Java of Indonesia Revealed the Macronutrient 94 ORIGINAL PAPER | MEd ARch. 2021 APR; 75(2): 94-100 Purple Sweet Potatoes from East Java of Indonesia Revealed the Macronutrient, Anthocyanin Compound and Antidepressant Activity Candidate Nia Kurnianingsih1,2,6, Retty Ratnawati2, Tommy Alfandy Nazwar3, Mulyohadi Ali4, Fatchiyah Fatchiyah5,6 ABSTRAcT Introduction: The development of new antidepressant is crucial to overcome the remis - sion rate limitation. Anthocyanin on purple sweet potatoes (PSP) from East Java cultivar previously demonstrated a behavioural effect. However, the certain mechanism and the nutritional compound need further exploration. Aim: This study aimed to characterize mac- ronutrient content, amino acids, anthocyanin, and revealed the potential of PSP from East Java-Indonesia as antidepressant agent through D2-dopamine receptor (D2DR). Methods: This study was characterized the macronutrient content using proximate analysis. The amino acids were analysed using Ultra-Performance Liquid Chromatography (UPLC) and High-Performance Liquid Chromatography (HPLC). Anthocyanin was identified using Ultra High-Performance Liquid Chromatography (UHPLC). Molecular docking was conducted to predict the interaction between anthocyanins and D2 dopamine receptor. Results: We were found the predominance of water on proximate analysis. Alanine was demonstrated as the highest content of amino acid. Cyanidin, cyanidin-3-O-glucoside and peonidin-3-O-gluco - side were identified as major anthocyanin content. Molecular docking was showed that cyanidin bound to similar binding site with dopamine on D2DR with stronger interaction than cyanidin-3-glucoside. Conclusion: Current study was indicated that cyanidin as major anthocyanin from purple sweet potatoes has potential health beneficial as antidepressant potential candidate
English Abstract
Purple Sweet Potatoes from East Java of Indonesia Revealed the Macronutrient 94 ORIGINAL PAPER | MEd ARch. 2021 APR; 75(2): 94-100 Purple Sweet Potatoes from East Java of Indonesia Revealed the Macronutrient, Anthocyanin Compound and Antidepressant Activity Candidate Nia Kurnianingsih1,2,6, Retty Ratnawati2, Tommy Alfandy Nazwar3, Mulyohadi Ali4, Fatchiyah Fatchiyah5,6 ABSTRAcT Introduction: The development of new antidepressant is crucial to overcome the remis - sion rate limitation. Anthocyanin on purple sweet potatoes (PSP) from East Java cultivar previously demonstrated a behavioural effect. However, the certain mechanism and the nutritional compound need further exploration. Aim: This study aimed to characterize mac- ronutrient content, amino acids, anthocyanin, and revealed the potential of PSP from East Java-Indonesia as antidepressant agent through D2-dopamine receptor (D2DR). Methods: This study was characterized the macronutrient content using proximate analysis. The amino acids were analysed using Ultra-Performance Liquid Chromatography (UPLC) and High-Performance Liquid Chromatography (HPLC). Anthocyanin was identified using Ultra High-Performance Liquid Chromatography (UHPLC). Molecular docking was conducted to predict the interaction between anthocyanins and D2 dopamine receptor. Results: We were found the predominance of water on proximate analysis. Alanine was demonstrated as the highest content of amino acid. Cyanidin, cyanidin-3-O-glucoside and peonidin-3-O-gluco - side were identified as major anthocyanin content. Molecular docking was showed that cyanidin bound to similar binding site with dopamine on D2DR with stronger interaction than cyanidin-3-glucoside. Conclusion: Current study was indicated that cyanidin as major anthocyanin from purple sweet potatoes has potential health beneficial as antidepressant potential candidate
| Item Type: | Article |
|---|---|
| Depositing User: | soegeng sugeng |
| Date Deposited: | 16 Dec 2021 04:15 |
| Last Modified: | 16 Dec 2021 04:15 |
| URI: | http://repository.ub.ac.id/id/eprint/187408 |
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