Lebang, Melita Nono and Prof. Dr. Ir. Chanif Mahdi, MS and drh. Fajar Shodiq Permata, M. Biotech (2020) Pengaruh Terapi Tepung Tapioka Terhadap Kadar Malondialdehyde dan Gambaran Histopatologi Organ Lambung pada Tikus (Rattus norvegicus) Model IBD Hasil Induksi Indometasin. Sarjana thesis, Universitas Brawijaya.
Abstract
IBD merupakan kondisi inflamasi pada saluran pencernaan yang dapat disebabkan efek samping obat non steroidal anti-inflammatory drugs, seperti indometasin. Pati resisten dalam tepung tapioka berperan sebagai mukoprotektan pada mukosa lambung. Penelitian ini bertujuan untuk mengetahui pengaruh terapi tepung tapioka terhadap penurunan kadar Malondialdehida MDA dan gambaran histopatologi lambung tikus (Rattus novergicus) model IBD hasil induksi indometasin. Penelitian ini bersifat eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL). Hewan coba menggunakan tikus (Rattus norvegicus) jantan strain wistar berumur 8-12 minggu dengan berat 150-200 gram. Tikus dibagi dalam 5 kelompok perlakuan; kelompok kontrol, kelompok IBD, dan kelompok terapi masing-masing diinduksi indometasin dan terapi tepung tapioka dengan dosis masing-masing 0,9 mg/kg BB, 1,8 mg/kg BB, dan 3,6 mg/kg BB. Kadar MDA lambung dianalisa dengan oneway ANOVA dan histopatologi lambung dianalisa secara deskriptif. Hasil analisis data menunjukkan bahwa tidak terdapat perbedaan yang signifikan antar kelompok perlakuan terhadap penurunan kadar MDA (P>0,05). Kesimpulan penelitian ini adalah pemberian terapi tepung tapioka tidak dapat menurunkan kadar MDA, walaupun ada kecenderungan menurun dan juga pada perbaikan jaringan lambung pada tikus model Inflammatory Bowel Disease.
English Abstract
IBD is an inflammatory condition in the digestive tract that can be caused by side effects of non steroidal anti-inflammatory drugs, such as indomethacin. Resistant starch in tapioca flour acts as a mucoprotectant in the gastric mucosa. This study aims to determine the effect of tapioca flour therapy on decreasing levels of MDA Malondialdehyde and histopathological features of rats (Rattus novergicus) IBD indometacin induction model. This research is experimental by using a completely randomized design (CRD). Experimental animals use male rats (Rattus norvegicus) wistar strains aged 8-12 weeks weighing 150-200 grams. Rats were divided into 5 treatment groups; the control group, the IBD group, and the therapeutic group were induced by indomethacin and tapioca flour therapy with a dose of 0.9 mg / kg body weight, 1.8 mg / kg body weight, and 3.6 mg / kg body weight respectively. Gastric MDA levels were analyzed by oneway ANOVA and gastric histopathology was analyzed descriptively. The results of data analysis showed that there were no significant differences between the treatment groups for the reduction in MDA levels (P> 0.05). The conclusion of this study is the administration of tapioca flour therapy can not reduce MDA levels, although there is a downward trend and also in the improvement of gastric tissue in rat model of Inflammatory Bowel Disease.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2020/32/052003835 |
| Uncontrolled Keywords: | Inflamatory Bowel Disease, Indometasin, mukoprotektan, Tepung Tapioka, MDA dan Histopatologi Lambung. Inflammatory Bowel Disease, Indomethacin, mucoprotector, Tapioca Flour, MDA and Gastric Histopathology. |
| Subjects: | 600 Technology (Applied sciences) > 636 Animal husbandry > 636.08 Specific topics in animal husbandry > 636.085 Feeds and applied nutrition > 636.085 2 Applied nutrition |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 07:35 |
| Last Modified: | 11 Apr 2023 03:58 |
| URI: | http://repository.ub.ac.id/id/eprint/181304 |
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