Anggraeni, Trisha Astari (2019) Perbedaan Kadar Transaminase Pada Penderita Tuberkulosis Anak Sebelum Dan Sesudah Terapi Intensif. Sarjana thesis, Universitas Brawijaya.
Abstract
Penyakit Tuberkulosis (TBC) menjadi masalah kesehatan global yang besar dan masuk dalam 10 besar penyakit penyebab kematian di dunia. Menurut World Health Organization, Indonesia menduduki peringkat kesembilan di dunia. Isoniazid, Rifampisin dan Pirazinamid merupakan regimen terapi yang standar digunakan untuk pasien TBC anak. Hepatotoksisitas merupakan efek samping paling serius, ditandai dengan meningkatnya kadar transaminase. Penelitian ini bertujuan untuk mengetahui perbedaan kadar SGOT dan SGPT pada pasien TBC sebelum dan sesudah pemberian OAT fase intensif. Desain penelitian yang digunakan adalah desain observasional analitik dengan rancangan pre-post test SGOT dan SGPT diperiksa pada serum menggunakan metode kolorimetri. Pengamatan dilakukan sebelum dan sesudah terapi intensif OAT menggunakan Isoniazid 50 mg, Rifampisin 75 mg, dan Pirazinamid 150 mg selama 2 bulan. Data yang didapat kemudian dianalisis dengan uji Wilcoxon, uji Kruskall-Wallis dan uji Mann-Whitney. Kadar SGOT dan SGPT diperiksa sebelum dan sesudah terapi OAT fase intensif. Hasil penelitian pada 30 subjek menunjukkan perbedaan kadar SGOT yang signifikan (p=0,019; α < 0,05), SGOT yang lebih tinggi dari normal bukan berarti ada gangguan pada hepar, karena SGOT tidak hanya ada di hepar; kadar SGPT tidak signifikan (p=0,223; α < 0,05), maka penghentian OAT tidak perlu dilakukan. OAT diberikan kembali jika fungsi hepar kembali normal, dengan dosis lebih kecil yang masih masuk dalam rentang terapi, dengan tetap memonitor kadar enzim terapi (Kementerian Kesehatan Republik Indonesia, 2016).
English Abstract
Tuberculosis (TB) is a major global health problem and is one of the 10 leading causes of death in the world. According to the World Health Organization, Indonesia is ranked ninth in the world. Isoniazid, Rifampicin and Pirazinamid are standard therapeutic regimens used for pediatric TB patients known as directly observed treatment short-course (DOTS). Hepatotoxicity is the most serious side effect, characterized by increased levels of transaminases. This study aims to determine the difference of SGOT and SGPT level in TB patients before and after administration of intensive phase of DOTS. The study design used was an analytic observational design with a pre-post SGOT and SGPT pre-test design examined for serum using the colorimetric method. Observations were made before and after intensive DOTS therapy using Isoniazid 50 mg, Rifampicin 75 mg, and Pirazinamid 150 mg for 2 months. The data obtained were then analyzed using the Wilcoxon test, the Kruskall-Wallis test and the Mann-Whitney test. SGOT and SGPT levels were examined before and after intensive phase of DOTS. The results of the study on 30 subjects showed significant differences in SGOT levels (p = 0.019; α <0.05), elevation of SGOT level doesn’t mean any liver injuries, since SGOT can also be found at other organs; while SGPT levels were not significant (p = 0.223; α <0.05), therefore DOTS no need to be stopped. It is re-administered if liver function returns to normal, with smaller doses that are still in the therapeutic range, while monitoring enzyme level.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/491/052001302 |
| Uncontrolled Keywords: | Tuberkulosis, SGOT, SGPT, terapi intensif-Tuberculosis, SGOT, SGPT, intensive therapy |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.64 Orthodontics and pediatric dentistry |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 10 Aug 2020 07:27 |
| Last Modified: | 22 Oct 2021 06:43 |
| URI: | http://repository.ub.ac.id/id/eprint/180041 |
Preview |
Text
Trisha Astari Anggraeni.pdf Download (8MB) | Preview |
Actions (login required)
 |
View Item |