Noviardi, Dira Intan Triayu Putri (2019) Hubungan Antara Kadar Procalcitonin dengan Derajat Keparahan Pneumonia di RSUD Dr.Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.
Abstract
Pneumonia merupakan penyakit infeksi akut disebabkan mikroorganisme yang terjadi pada saluran nafas mengenai jaringan paru-paru. Pada progesifitas penyakit Pneumonia terjadi peningkatan mediator proinflamasi (TNF-α, IL-6, IL-1) yang menginduksi peningkatan pengeluaran procalcitonin yang signifikan dari organ parenkim dan menyebabkan peradangan pada jaringan paru. peradangan ini menyebabkan alveoli mengalami konsolidasi sehingga alveoli terisi cairan dan padat. Hal ini menyebabkan pasokan oksigen yang masuk berkurang, nafas menjadi sulit dan terasa sakit. Procalcitonin (PCT) merupakan biomarker yang sensitiff dan spesifik dalam menentukan penyebab inflamasi. Peningkatan kadar PCT diduga berhubungan dengan derajat keparahan Pneumonia. penelitian ini bertujuan untuk mengetahui hubungan kadar procalcitonin dengan derajat keparahan pneumonia pada pediatric di RSUD Dr. Syaiful Anwar Malang dengan melakukan pengambilan data 48 pasien yang sudah tercatat di rekam medis rumah sakit. Data yang diambil meliputi kadar PCT dan Reapiratory rate, pernafasan cuping hidung serta ada tidaknya retraksi dinding dada untuk mengetahui derajat keparahan pneumonia yang ditentukan berdasarkan kriteria pada Buku Pedoman tatalaksana Pneumonia 2015. Hasil penelitian menunjukkan peningkatan kadar PCT secara signifikan dapat meningkatkan derajat keparahan Pneumonia.
English Abstract
Pneumonia is an acute infection disease due to mikroorganisms that occurs in the airways and affect the lungs. In the progession of pneumonia there is an increase in proinflammatory chemokine (TNF-α, IL-6, IL-1) which induces a significant increase in procalcitonin secretion from the parenchymal organs and cause inflammation in the lungs. This inflammation cause consolidation in the alveoli which makes alveoli are filled with fluid and solid. This causes a reduction in supply oxygen, breathing becomes difficult and painful. Procalcitonin (PCT) is a sensitive and specific biomarker in determining the cause of inflammation. High level of PCT is thought to be related to the severity of pneumonia. This research aims to know about the correlation between PCT level and the severity of pneumonia in pediatrics at Dr. Saiful Anwar Hospital Malang by taking data on 48 patients who had been recorded in hospital medical records. Data taken include PCT level and Respiratory rate, nasal breathing and the presence of chest wall retraction to determine the severity of pneumonia based on the 2015 pneumonia management book. The result showed a significant increase of PCT levels could increase the severity of pneumonia.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/394/052001239 |
| Uncontrolled Keywords: | Kadar Procalcitonin (PCT), Derajat Keparahan Pneumonia, Pediatric-Procalcitonin (PCT) level, Severity of pneumonia, Pediatrics. |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.929 7 Staphylococcal infections |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 18 Aug 2020 03:13 |
| Last Modified: | 22 Oct 2021 07:55 |
| URI: | http://repository.ub.ac.id/id/eprint/179884 |
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