Perbedaan jumlah fibroblas pada penyembuhan ulkus traumatik tikus wistar (rattus novergicus) setelah pemberian nanogel getah jarak ja (jatropha multifida l).

Arifin, Zainal (2018) Perbedaan jumlah fibroblas pada penyembuhan ulkus traumatik tikus wistar (rattus novergicus) setelah pemberian nanogel getah jarak ja (jatropha multifida l). Sarjana thesis, Universitas Brawijaya.

Abstract

Sariawan atau ulser merupakan inflamasi yang terjadi pada mukosa rongga mulut meliputi gingiva, mukosa pipi, mukosa palatum, lidah bibir dan dasar mulut. Proses penyembuhan ulser sangat dipengaruhi sel fibroblas. Ekstrak nanogel getah jarak cina mengandung senyawa kimia alkanoid, latexonin, tanin dan flavonoid sebagai antioksidan, antibakteri, antiinflamasi, dan meningkatkan kolagen tipe sehingga mampu mempercepat penyembuhan luka ulser pada mukosa. Tujuan dari penelitian ini untuk mengetahui perbedaan jumlah fibroblas pada penyembuhan ulkus traumatik tikus wistar (Rattus norvegicus) setelah pemberian ekstrak gel getah jarak cina (Jatropha multifida L). Penelitian ini menggunakan desain Randomized Post-Test Only Control Group Design yang dibagi menjadi empat kelompok yaitu kelompok kontrol (K1) dan kelompok perlakuan yang diberi ekstrak nanogel getah jarak cina ( P1, P2, dan P3) . Pada hari kelima tikus didekaputasi dan dibuat preparat histologi jaringan untuk menghitung jumlah fibroblas. Uji homogenitas dan normalitas menunjukkan bahwa data homogen dan berdistribusi normal. Uji One Way ANOVA menunjukkan nilai signifikansi 0,000 artinya ada perbedaan signifikan jumlah sel fibroblas pada tiap kelompok. Berdasarkan penelitian ini dapat disimpulkan bahwa ada perbedaan jumlah sel fibroblas pada tikus wistar (Rattus norvegicus) terhadap pemberian ekstrak nanogel getah jarak cina (Jatropha multifida L).

English Abstract

Thrush or ulceration is inflammation that occurs in the oral mucosa including the gingiva, cheek, palate, lip tongue and mouth floor. Wound healing process is strongly influenced by fibroblast cells. Nanogel Jarak Cina latex extract contains alkanoid, latexonin, tannin and flavonoid as antioxidants, antibacterial, anti-inflammatory, and increases collagen type 1 that it can accelerate wound healing of ulceration. The aim of this study was to determine the differences in the number of fibroblasts in healing traumatic ulcer wistar (Rattus norvegicus) mice after the administration of jarak cina latex extract (Jatropha multifida L). This study used the Randomized Post-Test Only Control Group Design which was divided in four groups, there are control group (K1) and the treatment group which were given jarak cina latex nanogels extraction (P1, P2, and P3). On the fifth day mice were decaputated and tissue histology preparations were made to count the number of fibroblasts. Homogeneity and normality tests show that the data is homogeneous and normally distributed. One Way ANOVA test showed a significance value of 0,000, the meaning there was a significant difference in the number of fibroblast cells in each group. Based on this study it can be concluded that there are differences in the number of fibroblast cells in wistar (Rattus norvegicus) rats for the administration of jarak cina nanogel extract (Jatropha multifida L).

Item Type:	Thesis (Sarjana)
Identification Number:	SKR/FKG/2019/8/052001762
Uncontrolled Keywords:	Ekstrak nanogel getah jarak cina (Jatropha multifida L), Fibroblas, Penyembuhan luka-Jarak cina nanogel latex extract (Jatropha multifida L), fibroblasts, wound healing.
Subjects:	600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.66 Extraction / Teeth--Extraction > 617.660 6 Teeth--Extraction--Treatment
Divisions:	Fakultas Kedokteran Gigi > Kedokteran Gigi
Depositing User:	soegeng sugeng
Date Deposited:	19 Jul 2020 07:10
Last Modified:	23 Oct 2021 04:48
URI:	http://repository.ub.ac.id/id/eprint/179416

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