Rafika, Nadia (2019) Pengaruh Nanotransfersom Ekstrak Kulit Jeruk Nipis (Citrus aurantifolia Swingle) terhadap Epitelisasi pada Penyembuhan Luka Mukosa Labial Tikus Wistar. Sarjana thesis, Universitas Brawijaya.
Abstract
Latar belakang: Ulkus traumatik merupakan hilangnya seluruh ketebalan epitel sehingga jaringan ikat dibawahnya terbuka serta menyebabkan terbentuknya luka dan memerlukan pergantian jaringan baru agar fungsi jaringan kembali normal, salah satunya dengan proliferasi epitel pada area perlukaan. Kulit jeruk nipis memiliki kandungan flavonoid yang dapat meningkatkan epitelisasi. Efektifitas obat dapat ditingkatkan dengan mengubah senyawa menjadi nanotransfersome. Nanotransfersome merupakan system pembawa obat. Tujuan: Mengetahui pengaruh pemberian nanotransfersome ekstrak kulit jeruk nipis (Citrus aurantifolia Swingle) terhadap epitelisasi pada penyembuhan luka mukosa labial tikus wistar. Metode: Metode penelitian menggunakan true experimental in vivo dengan induksi termal mukosa labial tikus, dibagi menjadi 4 kelompok dengan time series hari 3 dan 7, yaitu kelompok kontrol negatif (K(-)3 dan K(-)7), kelompok kontrol positif diberi triamcinolone acetonida 0,1% (K(+)3 dan K(+)7), kelompok perlakuan yang diberi ekstrak kulit jeruk nipis (P3A dan P7A), dan kelompok perlakuan yang diberi nanotransfersome ekstrak kulit jeruk nipis (P3B dan P7B). Ketebalan epitel diamati menggunakan mikroskop digital perbesaran 400x dan diukur ketebalannya dengan mikrometer digital. Hasil: Analisa data menggunakan uji One-way ANOVA menunjukkan terdapat perbedaan ketebalan epitel pada hari ke-3 dan ke-7. Kesimpulan: Nanotransfersome ekstrak kulit jeruk nipis (Citrus aurantifolia Swingle) berpengaruh terhadap epitelisasi pada penyembuhan luka mukosa labial tikus wistar.
English Abstract
Background: Traumatic ulcers is the opening of underlying connective tissue in the epithelium and can cause the formation of the wound and requires new tissue replacement until the function can return to normal, one of the main phase is the proliferation of epithelium in injury area. Lime peel contains flavonoids which can increase epithelialization. The effectiveness of the drug can be increased by changing the compounds into nanotransfersome. Nanotransfersome is a drug-delivery system. Purpose: To determine the effect of nanotransfersome lime peel extract (Citrus aurantifolia Swingle) to epithelialization for wound healing on labial mucosa in wistar rats. Method: This research used true experimental method in vivo with thermal induction of wistar rats labial mucous, divided into 4 groups with time series 3rd and 7th, that were negative control groups (K (-) 3 and K (-) 7), positive control groups that was given triamcinolone acetonide 0.1% (K (K ( +) 3 and K (+) 7), treatment groups that was given extracts of lime peel (P3A and P7A) and treatment groups that was given nanotransfersome extract of lime peel (P3B and P7B). Epithelial thickness was observed using a digital microscope with 400x magnification and the thickness obtained with digital micrometer. Result: Data analysis using the One-way ANOVA test showed differences in epithelial levels on days 3rd and 7th. Conclusion: Nanotransfersome lime peel extract (Citrus aurantifolia Swingle) has effects to epithelialization in healing wounds on labial mucosa of wistar rats.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2019/63/052001817 |
| Uncontrolled Keywords: | Epitelisasi, flavonoid, nanotransfersome ekstrak kulit jeruk nipis (Citrus aurantifolia Swingle), ulkus traumatik-Epithelialization, flavonoids, nanotransfersome lime peel extract (Citrus aurantifolia Swingle), traumatic ulcers. |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.66 Extraction / Teeth--Extraction |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 19 Jul 2020 07:10 |
| Last Modified: | 23 Oct 2021 04:11 |
| URI: | http://repository.ub.ac.id/id/eprint/179352 |
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