Ramadon, Agil Fajar (2019) Pengaruh Gel Ekstrak Daun Kersen (Muntingia calabura L.) terhadap Angiogenesis pada Penyembuhan Luka Pasca Pencabutan Gigi Tikus Putih (Rattus norvegicus). Sarjana thesis, Universitas Brawijaya.
Abstract
Angiogenesis berperan dalam penyembuhan luka untuk menyuplai oksigen dan nutrisi supaya dapat berproliferasi dengan baik. Gel ekstrak daun kersen (Muntingia calabura L.) mengandung senyawa flavonoid yang dapat membantu penyembuhan luka dan meningkatkan angiogenesis. Tujuan penelitan ini adalah untuk mengetahui pengaruh pemberian gel ekstrak daun kersen terhadap angiogenesis pada penyembuhan luka pasca pencabutan gigi tikus putih (Rattus norvegicus). Metode yang digunakan adalah true experimental secara in vivo. Sampel dipilih secara acak dan dibagi menjadi enam kelompok, yaitu kelompok yang tidak diberi gel ekstrak daun kersen (K3, K5, K7) dan kelomok yang diberi gel ekstrak daun kersen (P3, P5, P7), lalu dilakukan dekaputasi hari ketiga, kelima dan ketujuh. Soket gigi diambil dan dilakukan pewarnaan Hemaxtocylin-Eosin kemudian angiogenesis diamati menggunakan mikroskop digital. Hasil uji-t tidak berpasangan menunjukkan adanya perbedaan yang signifikan antara kelompok perlakuan dan kelompok kontrol (p<0,05). Berdasarkan hasil penelitian, dapat disimpulkan gel ekstrak daun kersen meningkatkan angiogenesis pada penyembuhan luka pasca pencabutan gigi tikus putih.
English Abstract
Angiogenesis plays a role in wound healing to supply oxygen and nutrients in order to proliferate well. Kersen leaf extract gel (Muntingia calabura L.) contains of flavonoids which can help wound healing and improve angiogenesis. The purpose of this study was to determine the effect of giving kersen leaf extract gel to the amount of angiogenesis in wound healing after tooth extraction in white rat. The study method was true experimental by using white rat (Rattus norvegicus). The sample was split randomly and divided into six groups, that was the control groups who were not given kersen leaf extract gel (K3, K5, K7) and the treatment groups was given a kersen leaf extract gel (P3, P5, P7) and each groups was decaputated in day third, fourth and seventh. Tooth sockets were taken and stained with Hematoxylin-Eosin then observed using a digital microscope. The results of the independet t-test showed there were significant differences between the treatments group and the control group (p<0,05). Based on this study, it can be concluded that kersen leaf extract gel enhances angiogenesis in wound healing after tooth extraction of white rat.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2019/68/052001822 |
| Uncontrolled Keywords: | Gel ekstrak daun kersen (Muntingia calabura L.), pencabutan gigi, angiogenesis-Kersen leaf extract gel (Muntingia calabura L.), tooth extraction, angiogenesis. |
| Subjects: | 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.66 Extraction / Teeth--Extraction |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 19 Jul 2020 07:01 |
| Last Modified: | 23 Oct 2021 04:08 |
| URI: | http://repository.ub.ac.id/id/eprint/179092 |
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