Muthia, Iffa Indah (2019) Efek Preventif Ekstrak Kulit Pisang Kepok (Musa Paradisiaca) Terhadap Kadar Trigliserida Dan Gambaran Histopatologi Aorta Pada Tikus Putih (Rattus Norvegicus) Model Hiperkolesterolemia. Sarjana thesis, Universitas Brawijaya.
Abstract
Hiperkolesterolemia merupakan kondisi dimana kadar kolesterol di dalam darah mengalami peningkatan dari batas normal. Ekstrak kulit pisang kepok (Musa paradisiaca) mengandung pektin, tanin, saponin, dan flavonoid yang memiliki efek preventif terhadap hiperkolesterolemia. Penelitian ini bertujuan untuk mengetahui efek preventif dari kulit pisang kepok (Musa paradisiaca) terhadap kadar trigliserida dan gambaran histopatologi aorta pada tikus putih (Rattus norvegicus) model hiperkolesterolemia. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 20 ekor tikus yang dikelompokkan menjadi kelompok kontrol negatif, kelompok hiperkolesterolemia, dan kelompok hiperkolesterolemia yang mendapat terapi ekstrak kulit pisang kepok (Musa paradisiaca) selama 21 hari dengan dosis 22,05mg/150gBB; 44,1mg/150gBB; dan 88,2mg/150gBB. Diet hiperkolesterolemia diberikan selama 14 hari (3,02g/150gBB) dengan komposisi minyak babi 10%, kuning telur puyuh 5% dan asam kholat 0,1%. Pemeriksaan kadar trigliserida menggunakan metode GPOPAP, dianalisis secara kuantitatif menggunakan uji ANNOVA (α=0,05) dan dilanjutkan dengan uji Tukey (p < 0,01). Sedangkan gambaran histopatologi aorta diamati dengan pewarnaan Hematoxilin-Eosin disajikan secara deskriptif. Hasil penelitian menunjukkan bahwa pemberian ekstrak kulit pisang kepok (Musa paradisiaca) pada masing-masing perlakuan secara sangat signifikan (p < 0,01) dapat menurunkan kadar trigliserida dan memperbaiki sel endotel dan tunika media pada gambaran histopatologi organ aorta. Kesimpulan dari penelitian ini adalah pemberian ekstrak kulit pisang kepok (Musa paradisiaca) dapat mencegah kenaikan kadar trigliserida dengan dosis terbaik adalah 88,2mg/150gBB serta memperbaiki gambaran histopatologi aorta.
English Abstract
Hypercholesterolemia is a condition where cholesterol levels in the blood have increased from normal limits. Kepok banana peel extract (Musa paradisiaca) contains pectin, tannins, saponins, and flavonoids which have a preventive effect on hypercholesterolemia. The purpose of this study was to determine the preventive effect of kepok banana peel (Musa paradisiaca) on triglyceride levels and aortic histopathological features in white rats (Rattus norvegicus) hypercholesterolemia models. This study use a Completely Randomized Design (CRD) with 20 rats grouped into the negative control group, the hypercholesterolemia group, and the hypercholesterolemia group who were treated with kepok banana peel extract for 21 days at a dose of 22,05mg/150gBB; 44,1mg/150gBB; and 88,2mg/150gBB. The hipercholesterolemic diet is given for 14 days (3,02g/150gBB) with 10% pork oil composition, 5% quail egg yolk and 0.1% cholic acid. Triglyceride level examination using the GPO-PAP method, analyzed quantitatively using the ANNOVA test (α = 0.05) and continued with the Tukey test (p <0.01). While the histopathology of aorta with Hematoxilin-Eosin staining will be presented descriptively. The result showed that administration of kepok banana peel extract (Musa paradisiaca) in each treatment gave very significantly different results (p<0,01) in preventing the increase in triglyceride levels and improve the endothelial cell and tunica media in the histopathological picture of aortic organ. The conclusion of this study is that administration of kepok banana peel (Musa paradisiaca) can prevent the increase in triglyceride levels with the best dose is 88,2 mg/150gBB and improve the histopathological picture of the aorta.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKH/2019/175/051910891 |
| Uncontrolled Keywords: | Ekstrak kulit pisang kepok, Hiperkolesterolemia, Histopatologi aorta, Kadar trigliserida, Aorta histopathology, Hypercholesterolemia, Kepok banana peel, Triglyseride level |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.321 Drugs derived from plants |
| Divisions: | Fakultas Kedokteran Hewan > Kedokteran Hewan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 19 Jul 2020 06:44 |
| Last Modified: | 21 Oct 2021 06:42 |
| URI: | http://repository.ub.ac.id/id/eprint/177011 |
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