Uji Efektivitas Terapi Hepatitis B Kronis Terhadap Penurunan Derajat Fibrosis Hati Berdasarkan Skor APRI, FIB-4, dan Fibroscan di RSUD Dr. Saiful Anwar Malang.

Permatasari, An Nisa Rizqa (2019) Uji Efektivitas Terapi Hepatitis B Kronis Terhadap Penurunan Derajat Fibrosis Hati Berdasarkan Skor APRI, FIB-4, dan Fibroscan di RSUD Dr. Saiful Anwar Malang. Sarjana thesis, Universitas Brawijaya.

Abstract

Hepatitis merupakan peradangan hati akibat virus Hepatitis B yang banyak menyerang penduduk Indonesia. Penderita hepatitis B berpotensi mengalami sirosis hati apabila tidak tertangani dengan baik. Diperlukan adanya evaluasi kerusakan sel hati pada terapi pasien hepatitis B kronis. Metode non invasif menjadi salah satu metode dalam pengukuran kerusakan sel hati. Penelitian ini bertujuan mengetahui gambaran setiap derajat fibrosis pada skor APRI dan FIB-4 serta gambaran efektivitas terapi antihepatitis terhadap fibrosis hati. Penelitian dilakukan retrospektif menggunakan data sekunder berupa rekam medis pasien. Diambil 27 pasien dengan diagnosis hepatitis B kronis tanpa koinfeksi, berusia 21-70 tahun, dan telah diberi terapi antivirus maupun imunomodulator selama ± 24 minggu. Pengukuran derajat fibrosis hati menggunakan skor APRI dan FIB-4 menunjukkan korelasi positif terhadap Fibroscan (p APRI = 0,831; p FIB-4 = 0,686). Perubahan derajat fibrosis hati pada terapi tenofovir; telbivudin; dan Peg IFN α sebesar 0,143 ± 0,378; 0,778 ± 0,808; dan -1,500 ± 0,707 (p = 0,001). Pada penelitian ini disimpulkan bahwa terdapat perbedaan derajat fibrosis hati menggunakan skor APRI dan FIB-4, serta terdapat penurunan derajat fibrosis pada pemberian antivirus namun tidak pada pemberian imunomodulator.

English Abstract

Hepatitis is an inflammation of the liver due to the Hepatitis B virus which attacks many Indonesian. Hepatitis B sufferers potentially have liver cirrhosis if not handled properly. Evaluation of liver cell damage is needed in the treatment of chronic hepatitis B. The non-invasive method is one method for measuring liver cell damage. This study aims to determine the description of each degree of fibrosis in APRI and FIB-4 scores and an overview of the effectiveness of anti-hepatitis therapy in liver fibrosis. The study was conducted retrospectively using secondary data in the form of patient medical records. 27 patients were taken with a non-co-infected chronic hepatitis B diagnosis, aged 21-70 years, and had been given antiviral or immunomodulatory therapy for ± 24 weeks. Measuring the degree of liver fibrosis using APRI and FIB-4 scores showed a positive correlation to fibroscan (p APRI = 0.831; p FIB-4 = 0.686). Changes in the degree of liver fibrosis on tenofovir therapy; telbivudine; and Peg IFN α are 0.143 ± 0.378; 0.778 ± 0.808; and -1,500 ± 0,707 (p = 0,001). In this study, it was concluded that there were differences in the degree of liver fibrosis using APRI and FIB-4 scores, and there was a decrease in the degree of fibrosis in antiviral administration but not in immunomodulatory administration.

Other obstract

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Item Type: Thesis (Sarjana)
Identification Number: SKR/FK/2019/248/051909331
Uncontrolled Keywords: Hapatitis B Kronis, APRI, FIB-4, Fibroscan, fibrosis hati, Chronic Hepatitis B, APRI, FIB-4, Fibroscan, Liver fibrosis
Subjects: 600 Technology (Applied sciences) > 616 Diseases > 616.3 Diseases of digestive system > 616.36 Diseases of biliary tract and liver
Divisions: Fakultas Kedokteran > Farmasi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 26 Aug 2020 04:28
Last Modified: 22 Oct 2021 03:24
URI: http://repository.ub.ac.id/id/eprint/175429
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