Aldi, Alfin Septia Putri (2019) Pengaruh Suplementasi Besi (Fe) Dosis Tinggi terhadap Kondisi Sel Beta Pankreas pada Tikus Putih (Rattus Norvegicus) Strain Wistar Bunting. Sarjana thesis, Universitas Brawijaya.
Abstract
Selama masa kehamilan, ibu hamil membutuhkan berbagai zat gizi. Salah satu zat gizi yang diperlukan yaitu zat besi. Zat besi berfungsi untuk pembentukan hemoglobin. Kelebihan zat besi dapat meningkatkan radikal bebas dan memicu stress oksidatif. Penelitian ini bertujuan untuk mengetahui efek pemberian suplementasi besi dosis tinggi terhadap kondisi sel beta pankreas tikus putih (Rattus novergicus) strain wistar bunting. Kondisi sel beta pankreas yang dilihat adalah jumlah sel beta dihitung menggunakan mikroskop dengan perbesaran 400x. Suplementasi besi diberikan 18 hari dengan 3 dosis berbeda (0,54mg, 1,08mg, dan 2,16mg). Jumlah sel beta pankreas berbeda signifikan antar kelompok kontrol dan perlakuan (p=0,000), rerata jumlah sel beta pankreas terkecil pada kelompok (P3) 12,17. Suplementasi besi dapat menurunkan jumlah sel beta pankreas pada tikus putih (Rattus novergicus) strain wistar bunting.
English Abstract
During pregnancy, pregnant women need various nutrients. One of the nutrients need is iron. Iron functions for the formation of hemoglobin. Excess iron can increase free radicals and trigger oxidative stress. The aim of this study was to determine the effect of high doses of iron supplementation on the condition of the beta cells pancreas of the pregnant wistar white rat (Rattus novergicus). The condition of pancreatic beta cells seen is the number of beta cells calculated using a microscope with 400x magnification. Iron supplementation was given 18 days with 3 different doses (0.54mg, 1.08mg, and 2.16mg). The number of pancreatic beta cells differed significantly between the control and treatment groups (p = 0,000), the mean number of the smallest pancreatic beta cells in the group (P3) 12,17. Iron supplementation can reduce the number of pancreatic beta cells in pregnant wistar white rat (Rattus novergicus).
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2019/111/051909210 |
| Uncontrolled Keywords: | Zat Besi(Fe), Sel beta pankreas, Stress Oksidatif, Iron suplementation, number of pancreatic beta cells, oxidative stress |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.107 24 Experimental research |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 19 Jul 2020 04:21 |
| Last Modified: | 11 Mar 2022 07:19 |
| URI: | http://repository.ub.ac.id/id/eprint/175234 |
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