Prototipe Hand Sanitizer Nanoemulsi Berbasis Surfaktan Alami Lerak (Sapindus rarak) sebagai Antibakteri

Putri, Dinisa Eka (2018) Prototipe Hand Sanitizer Nanoemulsi Berbasis Surfaktan Alami Lerak (Sapindus rarak) sebagai Antibakteri. Sarjana thesis, Universitas Brawijaya.

Abstract

Telah dilakukan optimasi komposisi bahan dalam pembuatan nanoemulsi Hand Sanitazer dengan menggunakan pendekatan metoda permukaan respons. Bahan-bahan tersebut terdiri dari ekstrak lerak yang mempunyai aktivitas antibakteri Staphylococcus aureus, etanol dan Tween 80. Ketiga bahan tersebut diformulasikan menurut metoda permukaan respons Box-Behken sehingga dihasilkan 17 formula yang kemudian diuji karakternya meliputi ukuran nanoemulsi, kejernihan larutan, kestabilan larutan, kelngketan dan kecepatan kering. Pembentukan nanoemulsi dengan surfaktan Lerak pada prototipe hand sanitizer dengan dibantu proses sonikasi selama 2 jam dapat menghasilkan distribusi nanoemulsi berukuran 296 - 1000 nm sebanyak 1%. Optimasi hasil prototipe nanoemulsi hand sanitizer yang dilakukan menggunakan Design Expert 6.0.8 Portable menghasilkan komposisi optimum etanol 86,18%, ekstrak Lerak 2% dan tween 80 0,21%. Pada komposisi tersebut menghasilkan titik optimal yang diprediksi memiliki ukuran nanoemulsi sebesar 667 nm dengan tingkat kejernihan 60,60%, stabilitas nanoemulsi lebih besar 5 jam 61,48%. Respon panellist terhadap kelengketan sebesar 52,42% (tidak lengket) dan kecepatan kering kurang dari 1 menit sebesar 89,88%.

English Abstract

An optimization of the material composition has been made for Hand Sanitizer nanoemulsion by using surface response method approach. The ingredients consisted of extracts of Lerak which had an antibacterial activity of Staphylococcus aureus, ethanol and Tween 80. The three materials were formulated according to Box-Behnken response surface method so that 17 formulas were obtained then tested against to the characteristic of the formula including size of nanoemulsion, tansmittance of solution, stability of nanoemulsion, sticky power and long dryness. The formation of nanoemulsion with surfactant on the hand sanitizer was performed by using sonication for 2 hours, that can result the size of nanoemulsion around 296 - 1000 nm at 1% distribution level. The Design Expert 6.0.8 was used for optimal composition of the prototype. The result show that the composition was at optimum emulsion consist of 86.18% ethanol, 2% Lerak extract and 0.21% Tween 80. This composition was predicted to have the size of nanoemulsion was at 667 nm with a tansmittance of solution 60,60%, the stability of nanoemulsion 61,48%, sticky power 52,42% and long dryness 89,88%.

Item Type: Thesis (Sarjana)
Identification Number: SKR/MIPA/2018/353/051807406
Uncontrolled Keywords: Ekstrak Lerak, Nanoemulsi, Metode Permukaan Respon. Lerak extract, Nanoemulsion, Surface Response Method
Subjects: 600 Technology (Applied sciences) > 668 Technology of other organic products > 668.1 Surface-active agents (surfactants)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam > Kimia
Depositing User: Budi Wahyono Wahyono
Date Deposited: 22 Jul 2020 06:30
Last Modified: 18 Oct 2021 03:48
URI: http://repository.ub.ac.id/id/eprint/168822
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