Evelyn, Maria (2018) Efek Pemberian Ekstrak Etanol Daun Cocor Bebek (Bryophyllum pinnatum) terhadap Ulkus Peptikum Lambung Tikus Strain Wistar yang Diinduksi Indometasin. Sarjana thesis, Universitas Brawijaya.
Abstract
Kandungan fitokimia daun cocor bebek (Bryophyllum pinnatum) dilaporkan mengandung bebagai zat seperti saponin, flavonoid, dan tanin yang memiliki berbagai manfaat di antaranya sebagai antiinflamasi, antioksidan, antialergi, antikarsinogenik, dan lain-lain. Inflamasi adalah mekanisme utama yang mendasari terbentuknya ulkus peptikum akibat induksi indometasin. Tujuan penelitian ini adalah untuk mengetahui efek pemberian ekstrak etanol daun cocor bebek dalam memperbaiki ulkus peptikum pada lambung tikus strain wistar yang diinduksi indometasin. Rancangan penelitian ini menggunakan metode true experimental post test-only control group design. Penentuan sampel secara randomisasi, yaitu menggunakan 25 ekor tikus putih jenis Rattus norvegicus, yang dibagi dalam 5 kelompok. Kelompok kontrol negatif tidak diberikan perlakuan apapun, kelompok kontrol positif diberikan indometasin 30 mg/kgBB, kelompok perlakuan 1, 2, dan 3, diberikan indometasin 30mg/kgBB dan ekstrak etanol daun cocor bebek 100mg/kgBB, 200mg/kgBB, dan 300mg/kgBB masing-masing secara berurutan. Parameter yang dinilai adalah skor keparahan lesi perdarahan secara makroskopis, karena perdarahan submukosa adalah manifestasi awal dari ulkus peptikum. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan (P<0,05) pada gambaran makroskopis lesi mukosa lambung antara kelompok kontrol positif dengan kelompok perlakuan 1 (100mg/kgBB) dan 2 (200mg/kgBB). Namun, tidak ditemukan adanya perbedaan yang signifikan (P>0,05) antara kontrol positif dengan kelompok perlakuan 3 (300mg/kgBB). Maka dapat disimpulkan bahwa ekstrak etanol daun cocor bebek dapat memperbaiki gambaran makroskopis lesi mukosa lambung tikus yang diinduksi indometasin pada pemberian dosis 100mg/kgBB hingga 200mg/kgBB, namun penambahan dosis hingga 300mg/kgBB diduga dapat meningkatkan resiko rusaknya integritas mukosa lambung terlihat dari meningkatnya derajat keparahan lesi.
English Abstract
Phytochemical composition of Bryophyllum pinnatum leaves has been reported showing the presence of bioactive substituents including saponins, flavonoids, and tannins which have various medicinal benefits as an inflammatory agent, antioxidant, antiallergy, anticarcinogenic, etc. Inflammation is the basic mechanism underlying the formation of indomethacin induced peptic ulcer. The purpose of this study is to determine the effect of administrating the ethanol extract of Bryophyllum pinnatum leaves on indomethacin induced peptic ulcer on wistar rat. This study used the true experimental post test-only control group design method. Randomly selected sample of 25 male wistar rat were than classified into 5 groups, the negative control group without any intervention given, the positive control group with 30mg/kgb.w. indomethacin administration, while the experimental groups 1, 2, 3 were administered with 30mg/kgb.w. indomethacin and Bryophyllum pinnatum leaves extract at dosage 100mg/kgb.w., 200mg/kgb.w., 300mg/kgb.w., respectively. The parameter assessed was the score of hemorrhagic lesion severity, remember that gastric hemorrhage is the early manifestation of peptic ulcer. The result of this study represents a significant difference in the macroscopic view of gastric mucosal lesions between the positive control group with the experimental group 1 (100mg/kgb.w.) and 2 (200mg/kgb.w.). However, there is no significant difference (P>0.05) between positive control group and experimental group 3 (300mg/kgb.w.). It can be concluded that, the ethanol extract of Bryophyllum pinnatum leaves at dosage 100mg/kgb.w. to 200mg/kgb.w. potentially improves the macroscopic view of rats’ gastric mucosal lesion induced by indomethacin, but adding the doses up to 300mg/kgb.w. can increase the risk of gastric mucosal damage featured by the increasing score in the severity of the lesion.
Other obstract
-
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/386/051811810 |
| Uncontrolled Keywords: | Cocor bebek, Bryophyllum pinnatum, Indometasin, Ulkus peptikum, Lesi perdarahan lambung, Bryophyllum pinnatum, Indomethacin, Peptic ulcer, Gastric hemorrhage lesio |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 72 Drugs derived from specific plants (Crassulaceae) |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 10 Jul 2019 02:11 |
| Last Modified: | 21 Oct 2021 05:49 |
| URI: | http://repository.ub.ac.id/id/eprint/168045 |
![[thumbnail of Maria Evelyn Suganda.pdf]](http://repository.ub.ac.id/style/images/fileicons/text.png) |
Text
Maria Evelyn Suganda.pdf Download (5MB) |
![[thumbnail of Thumbnails conversion from text to thumbnail_lightbox]](http://repository.ub.ac.id/168045/2/lightbox.jpg) |
Other (Thumbnails conversion from text to thumbnail_lightbox)
lightbox.jpg Download (40kB) |
![[thumbnail of Thumbnails conversion from text to thumbnail_preview]](http://repository.ub.ac.id/168045/3/preview.jpg) |
Other (Thumbnails conversion from text to thumbnail_preview)
preview.jpg Download (14kB) |
![[thumbnail of Thumbnails conversion from text to thumbnail_medium]](http://repository.ub.ac.id/168045/4/medium.jpg) |
Other (Thumbnails conversion from text to thumbnail_medium)
medium.jpg Download (4kB) |
![[thumbnail of Thumbnails conversion from text to thumbnail_small]](http://repository.ub.ac.id/168045/5/small.jpg) |
Other (Thumbnails conversion from text to thumbnail_small)
small.jpg Download (1kB) |
Actions (login required)
 |
View Item |