Gideon, Adolf (2018) Uji Efek Antiinflamasi Ekstrak Ethanol Daun Cocor Bebek (Bryophyllum pinnatum) pada Telapak Kaki Tikus Strain Wistar yang Diinduksi Ragi. Sarjana thesis, Universitas Brawijaya.
Abstract
Inflamasi merupakan mekanisme normal pertahanan tubuh terhadap luka jaringan yang disebabkan oleh trauma fisik, zat kimia yang merusak, atau zat-zat mikrobiologik. Cocor Bebek (Bryophyllum pinnatum) mengandung flavonoid, tanin dan saponin yang memiliki mekanisme sebagai antiinflamasi dengan menghambat mediator inflamasi seperti tirosin kinase, protein kinase c, phosphodiesterase, phospholipase A2, lipoxygenase dan cyclooxygenase serta tanin memiliki efek astrigent. Penelitian ini bertujuan untuk membuktikan bahwa cocor bebek memiliki efek antiinflamasi terhadap edema pada telapak kaki tikus yang diinduksi ragi. Penelitian ini merupakan studi eksperimental menggunakan post test only control group design yang dilakukan terhadap hewan coba tikus Wistar jantan. Sampel dipilih dan dibagi dalam 5 kelompok, yaitu kelompok kontrol negatif, kelompok kontrol positif yang diinduksi ragi, dan 3 kelompok perlakuan yang mendapat ekstrak ethanol cocor bebek masing-masing sebesar 50mg/kgBB, 100mg/kgBB, dan 200mg/kgBB. Variabel yang diukur adalah ukuran edema pada telapak kaki yang diinduksi oleh ragi dengan metode paw edema test. Hasil penelitian menunjukkan perbedaan ukuran edema pada telapak kaki tikus yang signifikan setelah diberi ekstrak ethanol cocor bebek (Anova, p=0.000). Uji Post Hoc Tukey menunjukkan perbedaan signifikan antara kelompok kontrol positif dengan kelompok yang mendapatkan ekstrak ethanol cocor bebek (p<0.05). Uji korelasi Pearson menunjukkan nilai korelasi Pearson -0.815 dan -0.841 masing-masing pada jam 1 dan 3 setelah pemberian ekstrak ethanol cocor bebek, yang berarti ada hubungan kuat dan berbanding terbalik menunjukkan bahwa semakin besar dosis cocor bebek, semakin kecil edema pada kaki tikus. Hasil uji regresi linear menunjukkan pengaruh ekstrak ethanol cocor bebek sebesar 70.7% terhadap edema pada telapak kaki tikus yang diinduksi ragi. Dapat disimpulkan bahwa ekstrak ethanol daun cocor bebek dapat memberikan efek antiinflamasi pada telapak kaki tikus model inflamasi yang diinduksi ragi.
English Abstract
Inflammation is a normal defense mechanism for our body to tissue injury due to physical trauma, damaging chemicals, or microbiological substances. Bryophyllum pinnatum contains flavonoids, tannins and saponins which have a mechanism as anti-inflammatory by inhibiting inflammatory mediators such as tyrosine kinase, protein kinase c, phosphodiesterase, phospholipase A2, lipoxygenase and cyclooxygenase and also tannins have an astrigent effect. This study aims to prove that cocor duck has an anti-inflammatory effect on edema in yeast-induced rat’s feet. This research is an experimental study using post test only control group design conducted on experimental male Wistar rats. Samples were choosen and divided into 5 group, which were negative control group, positive control group that induced by yeast, and 3 treatment groups which are given ethanol extract of Bryophyllum pinnatum each of 50mg/kg, 100mg/kg, and 200mg/kg. The variable measured was the size of edema in the soles of the feet induced by yeast using the paw edema test method. The results showed a significant difference in the size of edema in the soles of the rat's feet after being given ethanol extract of Bryophyllum pinnatum (Anova, p = 0.000). Post Hoc Tukey test showed a significant difference between the positive control group and the group that received ethanol extract of Bryophyllum pinnatum (p <0.05). Pearson correlation test showed Pearson correlation values of -0.815 and -0.841 respectively at 1 and 3 hours after administration of ethanol extract of Bryophyllum pinnatum, which means that there is a strong and inversely correlated relationship indicating that the greater the dose of Bryophyllum pinnatum, the smaller the edema in the rat's feet. Linear regression test result showed an effect of 70.7% of ethanol extract of Bryophyllum pinnatum on edema in yeast-induced rat’s feet. It can be concluded that the ethanol extract of Bryophyllum pinnatum can provide anti-inflammatory effects on yeast-induced rat’s feet.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/370/051811344 |
| Uncontrolled Keywords: | cocor bebek, inflamasi, paw edema test, telapak kaki, tikus, Bryophyllum pinnatum, inflammation, paw edema test, rat, soles of the feet |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.323 72 Drugs derived from specific plants (Crassulaceae) |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 10 Jul 2019 01:59 |
| Last Modified: | 21 Oct 2021 03:32 |
| URI: | http://repository.ub.ac.id/id/eprint/168004 |
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