Baskaren, Jivanathan A/L (2018) Efek Paparan Profilin Toxoplasma Gondii Terhadap Kadar Kolesterol Total Pada Tikus Rattus Norvegicus Strain Wistar Yang Diberikan Diet Normal Dan Diet Hiperkalori. Sarjana thesis, Universitas Brawijaya.
Abstract
Obesitas adalah akumulasi lemak tubuh yang abnormal dan memiliki banyak etiologi termasuk infeksi. Toxoplasma gondii adalah organisme parasit bersel tunggal yang dapat menginfeksi kebanyakan hewan dan burung. Berdasarkan penelitian sebelumnya, ada kemungkinan bahwa terdapat hubungan antara infeksi Toxoplasma gondii dan obesitas. T.gondii diklasifikasikan sebagai penyakit zoonosis dan mengandungi protein seperti profilin yang dapat merangsang sitokin pro-inflamasi sehingga terjadinya inflamasi dan diduga terkait dengan tingkat kadar kolesterol total. Penelitian ini dilakukan untuk mengetahui efek paparan profilin Toxoplasma gondii tehadap kadar kolesterol total pada tikus Rattus norvegicus Strain Wistar. Penelitian ini merupakan penelitian eksperimental laboratoris dengan rancangan true experimental-post test control group design. Hasil Uji Kruskal Wallis menunjukkan minimal ada satu pasang kelompok yang kadar kolesterolnya berbeda signifikan (P=0.012; α=≥0.05). Hasil uji Multiple Comparison (Post Hoc) – Dunn Bonferroni menunjukkan bahwa kelompok diet hiperkalori yang diinokulasi dua kali dengan profilin 30 μg/mL (D5) berbeda signifikan dengan kelompok diet normal yang diinokulasi dua kali dengan profilin 30 μg/mL (D2) dan kelompok normal diet yang diinokulasi dua kali dengan profilin 45 μg/mL (D3) (p=0.007; p=0.005, respectively). Dapat disimpulkan bahwa, kelompok yang diberikan diet hiperkalori maupun diet normal yang diinokulasi profilin 2 kali dan kelompok yang diberikan diet normal yang diinokulasi profilin 1 kali, kadar kolesterol total menurun akan tetapi pada kelompok yang diberikan diet normal yang diinokulasi profilin 1 kali, kadar kolesterol meningkat
English Abstract
Obesity is an abnormal body fat accumulation and has many etiologies including infection. Toxoplasma gondii is a single-celled parasitic organism that can infect most animals and birds. Based on previous research, there is a possibility that there is a relationship between Toxoplasma gondii infection and obesity. T.gondii is classified as a zoonotic disease and contains proteins such as profilin which can stimulate pro-inflammatory cytokines resulting in inflammation and is suspected to be associated with total cholesterol levels. This study was conducted to determine the effect of exposure profilin Toxoplasma gondii tehadap total cholesterol levels in Rattus norvegicus Strain Wistar rat. This research is a laboratory experimental research with true experimental-post test control group design. The results of Kruskal Wallis test showed there was at least one pair of groups whose cholesterol levels were significantly different (P = 0.012; α = ≥0.05). Multiple Comparison (Post Hoc) test results - Dunn Bonferroni showed that the rats inoculated twice and given hypercaloric diet group with 30 μg / mL (D5) profilin differed significantly from the normal diet group inoculated twice with profilin 30 μg / mL (D2) and the normal diet group which were inoculated twice with profilin 45 μg / mL (D3) (p = 0.007; p = 0.005, respectively). It can be concluded that the group given the hypercaloric diet as well as the normal diet inoculated profilin 2 times and the group given normal diet inoculated profilin 1 times, total cholesterol levels decreased but in the group given normal diet inoculated profilin 1 times, cholesterol level increased
Other obstract
-
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/24/051803010 |
| Uncontrolled Keywords: | Toxoplasma gondii, profilin, kolesterol total, Toxoplasma gondii, profilin, total cholesterol level |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.904 Special topics of communicable diseases > 616.904 1 Medical microbiology / Drug resistance in microorganisms |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 27 May 2020 12:49 |
| Last Modified: | 27 May 2020 12:49 |
| URI: | http://repository.ub.ac.id/id/eprint/167914 |
Actions (login required)
 |
View Item |