Efektivitas Antibakteri Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Pertumbuhan Bakteri Aggregatibacter actinomycetemcomitans Secara In Vitro

Auladana, Earnest Nur Zainun (2018) Efektivitas Antibakteri Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Pertumbuhan Bakteri Aggregatibacter actinomycetemcomitans Secara In Vitro. Sarjana thesis, Universitas Brawijaya.

Abstract

Periodontitis agresif merupakan infeksi bakteri yang merusak ligamen periodontal dan tulang alveolar secara luas dan singkat dalam waktu yang sangat cepat. Sering terjadi pada pasien dengan usia kurang dari 30 tahun. Pada gigi sulung, onset terjadi periodontitis agresif belum diketahui dengan pasti, tetapi kemungkinan muncul sekitar atau sebelum usia 4 tahun. Salah satu bakteri dominan penyebab periodontitis agresif adalah Aggregatibacter actinomycetemcomitans. Daun kenikir (Cosmos caudatus) merupakan salah satu tanaman yang mengandung senyawa aktif flavonoid, terpenoid, saponin, tanin dan alkaloid yang berpotensi sebagai antimikroba. Tujuan dari penelitian ini untuk mengetahui efektivitas ekstrak daun kenikir (Cosmos caudatus) sebagai antibakteri dalam menghambat pertumbuhan Aggregatibacter actinomycetemcomitans secara in vitro. Penelitian ini adalah eksperimental laboratoris dengan metode difusi sumuran untuk mendapatkan diameter zona hambat pertumbuhan bakteri Aggregatibacter actinomycetemcomitans. Konsentrasi ekstrak daun kenikir yang digunakan adalah 0%, 30%, 45%, 60%, 75%, 90% dan 100%. Analisis data menggunakan One- Way ANOVA menunjukkan adanya perbedaan yang signifikan pada perubahan konsentrasi ekstrak daun kenikir terhadap zona hambat pertumbuhan bakteri Aggregatibacter actinomycetemcomitans. Semakin meningkatnya konsentrasi ekstrak maka daya antibakteri semakin efektif. Berdasarkan penelitian ini, dapat disimpulkan bahwa ekstrak daun kenikir mempunyai efek sebagai antibakteri terhadap bakteri Aggregatibacter actinomycetemcomitans.

English Abstract

Aggressive periodontitis is a bacterial infection that damages periodontal ligaments and alveolar bone extensively and rapidly in a very short time. Usually affecting patients under 30 years old. In primary dentition, the exact time of onset is unknown but it appears to arise around or before 4 years old. One of the dominant bacteria that cause aggressive periodontitis is Aggregatibacter actinomycetemcomitans. The kenikir leaf (Cosmos caudatus) is one of the plants that contain active compounds of flavonoids, terpenoids, saponins, tannins and alkaloids that have antimicrobial potency. The purpose of this study to determine the effectiveness of kenikir leaf extract (Cosmos caudatus) as antibacterial in inhibiting the growth of Aggregatibacter actinomycetemcomitans. This research was a laboratory experimental study using well diffusion method to obtain the inhibition zone diameter of Aggregatibacter actinomycetemcomitans bacteria. The concentration of leaves extract used were 0%, 30%, 45%, 60%, 75%, 90% and 100%. Data analysis using One-Way ANOVA showed a significant difference in the concentration of kenikir leaf extract (Cosmos caudatus) to inhibition zone of bacterial growth of Aggregatibacter actinomycetemcomitans. The increasing concentration of extract the more effective antibacterial potency. Based on this research, in can be concluded that kenikir leaf extract (Cosmos caudatus) has antibacterial potency against Aggregatibacter actinomycetemcomitans.

Other obstract

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Item Type: Thesis (Sarjana)
Identification Number: SKR/FKG/2018/38/051805682
Uncontrolled Keywords: Aggregatibacter actinomycetemcomitans, daun kenikir (Cosmos caudatus), antibakteri, zona hambat Aggregatibacter actinomycetemcomitans, kenikir leaf (Cosmos caudatus), antibacterial, inhibition zone
Subjects: 600 Technology (Applied sciences) > 617 Surgery, regional medicine, dentistry, ophthalmology, otology, audiology > 617.6 Dentistry > 617.63 Dental diseases > 617.632 Diseases of gums and tooth sockets / Periodontics
Divisions: Fakultas Kedokteran Gigi > Kedokteran Gigi
Depositing User: Budi Wahyono Wahyono
Date Deposited: 25 May 2020 23:37
Last Modified: 22 Oct 2021 14:10
URI: http://repository.ub.ac.id/id/eprint/167827
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