Damayanti, Trisnani Adini (2018) Pengaruh Ekstrak Daun Sambiloto (Andrographis panniculata) Sebagai Antifungi Terhadap Candida albicans Pada Basis Akrilik Peranti Lepasan Ortodonti. Sarjana thesis, Universitas Brawijaya.
Abstract
Peranti ortodonti lepasan mempunyai banyak komponen. salah satu nya adalah basis akrilik. Akrilik tersebut, pada dasarnya mempunyai sifat mikroporositas, sehingga mikroorganisme yang terjebak pada mikroporositas tersebut akan terlalu sulit apabila dibersihkan hanya dengan menyikat nya saja. Dengan demikian, prevalensi pasien pengguna peranti lepasan ortodonti dengan kebersihan mulut yang buruk, ,untuk menderita kandidiasis akan lebih tinggi. Perendaman peranti ortodonti lepasan pada bahan kimia tertentu yang mempunyai efek antifungi, mampu menghambat bahkan membunuh fungi penyebab kandidiasis. Akan tetapi, biaya untuk mendapatkan bahan kimia tersebut relatif mahal, dan sudah banyak diketahui bahwa bahan kimia yang beredar di pasaran sudah menyebabkan resistensi. Untuk memcahkan masalah ini, dapat digunakan tanaman obat herbal sebagai agen antifungi pengganti bahan kimia. Daun smabiloto, dikenal mempunyai efek herbal untuk pengobatan. Dari penelitian yang telah dilakukan Sawitti dkk (2013) menyatakan bahwa daun smabiloto mengandung saponin, alkaloid, dan tanin. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui pada konsentrasi mana, ekstrak daun sambiloto mampu mengahambat pertumbuhan Candida albicans pada basis akrilik cold cured. Metode: sampel akrilik cold cured yang sudah terkontaminasi oleh Candida albicans direndam dalam tabung yang berisi ekstrak daun sambiloto dengan berbagai konsentrasi, kontrol positif dan kontrol negatif. Konsentrasi: 10%, 20%, 30%, 40%, 50%, aquadest dan Khlorhexidine sebagai kelompok kontrol. Hasil : terdapat perbedaan yang bermakna antar tiap kelompok konsentrasi. Kesimpulan: ekstrak daun sambiloto pada konsentrasi 30% mampu menghambat pertumbuhan Candida albicans pada basis akrilik peranti ortodonti lepasan.
English Abstract
Removable orthodontic appliances have many components. One of them, is acrylic base. The acrylic, basically has the properties of microporosity, so that microorganisms trapped in the microporosity will be too difficult if cleaned only by brushing it. Thus, the prevalence of patients using orthodontic devices with poor oral hygienes will be high risk to suffer candidiasis. Soaking removable orthodontic devices on certain chemicals that have antifungal effects can inhibit and even kill the causes of candidiasis. However, the cost of obtaining these chemicals is relatively expensive and it is well known that chemicals in the market have caused resistance. To solve this problem, herbal plants can be used as antifungal agents instead of chemicals. Sambiloto leaves, known to have herbal effects for treatment. From the research conducted by Sawitti et al (2013), it was stated that the smabiloto leaves contained saponins, alkaloids, and tannins. Objective: The aim of this study was to determine at which concentration, sambiloto leaf extract was able to inhibit the growth of Candida albicans on a self cured acrylic base. Methods: Cold cured acrylic samples that were contaminated by Candida albicans were soaked in tubes containing sambiloto leaf extract with various concentrations, positive controls and negative controls. Concentrations: 10%, 20%, 30%, 40%, 50%, aquadest and chlorhexidine as the control group. Results: there were significant differences between each concentration group. Conclusion: bitter leaf extract at a concentration of 30% was able to inhibit the growth of Candida albicans on the acrylic base of orthodontic removable devices.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FKG/2018/90/051900439 |
| Uncontrolled Keywords: | Candida albicans, daun sambiloto, akrilik cold cured, peranti ortodonti lepasan Candida albicans, Sambiloto leaves, cold cured acrylic base, removable orthodontic appliances. |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms |
| Divisions: | Fakultas Kedokteran Gigi > Kedokteran Gigi |
| Depositing User: | Budi Wahyono Wahyono |
| Date Deposited: | 11 May 2020 06:00 |
| Last Modified: | 22 Oct 2021 13:10 |
| URI: | http://repository.ub.ac.id/id/eprint/167771 |
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