Ramadani, Agung Febrian (2018) Optimasi Formula Fast Disintegrating Tablet (FDT) Mikrosfer Ekstrak Alga Cokelat (Hormophysa triquetra) menggunakan Superdisintegran Croscarmellose Sodium. Sarjana thesis, Universitas Brawijaya.
Abstract
Pasien dalam pengobatan kemoterapi mungkin mengalami mual yang sangat kuat, sehingga mempersulit konsumsi tablet yang biasanya dibantu dengan air. Salah satu strategi mengatasi masalah kesulitan mengonsumsi tablet pada pasien yang menjalani pengobatan kemoterapi adalah melalui pengembangan bentuk sediaan tablet yang didesain cepat hancur saat dalam rongga mulut yaitu Fast Disintegrating Tablet (FDT). Dalam penelitian ini FDT akan diaplikasikan sebagai teknologi penghantaran untuk mikrosfer ekstrak alga cokelat (Hormophysa triquetra). Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi Croscarmellose sodium terhadap sifat fisik FDT ekstrak Hormophysa triquetra sehingga diperoleh formula yang optimum. Sediaan FDT dibuat dengan menggunakan metode kempa langsung dengan variasi konsentrasi Croscarmellose sodium yaitu F1 (0%), F2 (2,5%), F3 (5%), dan F4 (15%). FDT ekstrak Hormophysa triquetra yang diperoleh kemudian diuji sifat fisiknya meliputi kerapuhan, waktu hancur, dan waktu keterbasahan. Hasil uji sifat fisik dianalisis menggunakan uji One-Way ANOVA pada derajat kepercayaan ɑ = 0,05. Pengaruh variasi konsentrasi Croscarmellose sodium terhadap sifat fisik FDT ekstrak Hormophysa triquetra dianalisis dengan uji Tukey untuk menghasilkan FDT ekstrak Hormophysa triquetra yang memiliki sifat fisik optimum. Hasil penelitian menunjukkan variasi konsentrasi Croscarmellose sodium dapat mempercepat waktu disintegrasi FDT ekstrak Hormophysa triquetra dan memberikan sifat fisik tablet yang optimum. Formula optimum FDT ekstrak Hormophysa triquetra berdasarkan hasil penelitian yang didapatkan adalah formula 2, 3, dan 4 dengan konsentrasi croscarmellose sodium secara berurutan 2,5%, 5%, dan 15%.
English Abstract
Patients in chemotherapy treatment may experience very strong nausea, which makes it difficult to consume tablets which are usually assisted with water. One strategy to overcome the problem of difficulty consuming tablets in patients undergoing chemotherapy treatment is through the development of tablet dosage forms that are designed to quickly disintegrate in the oral cavity, namely Fast Disintegrating Tablet (FDT). In this study, FDT will be applied as a delivery technology for microspheres of brown algae extract (Hormophysa triquetra). The purpose of this study was to determine the effect of variations in the concentration of croscarmellose sodium on the physical properties of FDT extract of Hormophysa triquetra so the optimum formula is obtained. FDT preparations were made using the direct compression method with variations in the concentration of croscarmellose sodium that is F1 (0%), F2 (2,5%), F3 (5%), and F4 (15%). FDT extract of Hormophysa triquetra has been obtained, then tested for physical properties including friability, disintegration time, and wetting time. The results of the physical properties test were analyzed using the One-Way ANOVA test at ɑ = 0,05. The effect of variations in the concentration of croscarmellose sodium on the physical properties of FDT extract of Hormophysa triquetra was analyzed by Tukey test to produce FDT extract of Hormophysa triquetra which have optimum physical properties. The results showed that variations in the concentration of Croscarmellose sodium can accelerate the disintegration time of FDT extract from Hormophysa triquetra and provide optimum physical properties of tablets. The optimum formula for FDT extract of Hormophysa triquetra based on the results of the research obtained are formulas 2, 3, and 4 with concentrations of croscarmellose sodium sequentially 2,5%, 5%, and 15%.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/491/051900643 |
| Uncontrolled Keywords: | Fast Disintegrating Tablet (FDT), Hormophysa triquetra, Croscarmellose sodium |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.1 Drugs (materia medica) > 615.19 Pharmaceutical chemistry |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 19 May 2020 14:22 |
| Last Modified: | 19 May 2020 14:22 |
| URI: | http://repository.ub.ac.id/id/eprint/167713 |
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