Rusti, Hafidh Fahreza (2018) Hubungan Pemeriksaan Who Disability Grading Dengan Kadar P75ntr Sebagai Marker Kerusakan Saraf Pada Lepra Tipe Multibasiler Dan Tipe Pausibasiler. Sarjana thesis, Universitas Brawijaya.
Abstract
Lepra merupakan penyakit menular kronis yang disebabkan oleh Mycobacterium leprae dan menyebabkan kerusakan pada saraf perifer, terutama sel Schwann. Pengobatan lepra hanya berguna untuk eradikasi bakteri, namun tidak dapat memulihkan atau mencegah kerusakan saraf sehingga deteksi dini kerusakan saraf untuk melihat keberadaan bakteri menjadi penting. Kami memeriksa kadar P75NTR sebagai deteksi awal dari kerusakan saraf tepi pada lepra denga skor WHO Disabilty Grading sebagai pembanding. Kami memeriksa pasien di Rumah Sakit Kusata Kediri. Studi Eksperimental ini memakai Uji korelasi spearman. ELISA digunakan untuk mengukur kadar P75NTR sebagai variable independen. Variabel dependen diukur berdasarkan skor pada WHO Disability Grading. Uji korelasi antara P75NTR dengan WHO Disability Grading menunjukkan koefisien korelasi sebesar 0.958 yang berarti terdapat korelasi yang sangat kuat karena mendekati angka 1 dengan p= 0.000 (p<0.05) yang menunjukkan signifikansi yang kuat pada Lepra tipe multibasiler. Sedangkan pada pasien Lepra tipe pausibasiler didapati nilai koefisien korelasi 0.977 yang berarti terapat korelasi yang sangat kuat dengan nilai signifikansi p= 0.000 (p<0.05). Lepra merupakan penyakit menular kronis yang menyebabkan kerusakan saraf perifer terutama sel Schwann. Deteksi dini kerusakan saraf sangat dibutuhkan. Pemeriksaan kadar P75NTR dapat digunakan sebagai deteksi awal kerusakan saraf tepi berkolerasi dengan WHO Disability Grading.
English Abstract
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and cause damage in peripheral nerve, especially Schwann Cell. Leprosy treatment is only useful for the bacterial eradication, but it cannot recover or prevent peripheral nerve damage so early neurological damage detection to determine the presence of bacteria is necessary. We examined the level of P75NTR as early detection of peripheral nerve damage in leprosy with WHO Disability Grading as comparison. We examined patient at Kediri Leprosy Hospital. The Experimental study using spearman correlation test. ELISA was used to measure the level of P75NTR as Independent Variable. The dependent variable was measured based on score of WHO Disability Grading. The Correlation test results between rate of P75NTR with WHO Disability Grading on MB showed the correlation coefficient value of 0.958 with p= 0.000. This means that there is very strong correlation between P75 and WHO Disability Grading on MB patients. The Correlation test results between rate of P75NTR with WHO Disability Grading on PB showed the correlation coefficient value of 0.977 with p= 0.000. This means that there is very strong correlation between P75 and WHO Disability Grading on PB patients. Leprosy is a chronic infectious disease that cause damage in peripheral nerve especially Schwann cells. Early detection of peripheral nerve damage is needed. Examination of P75NTR may be used for early detection correlated with WHO disability grading.
Other obstract
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| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/531/051900993 |
| Uncontrolled Keywords: | Lepra, WHO Disability Grading, P75NTR, Leprosy, WHO Disability Grading, P75NTR |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.9 Other disease > 616.99 Tumors and miscellaneous communicable diseases > 616.998 Hansen's disease (Leprosy) > 616.998 06 Leprosy--Treatment |
| Divisions: | Fakultas Kedokteran > Pendidikan Dokter |
| Depositing User: | Nur Cholis |
| Date Deposited: | 18 May 2020 16:48 |
| Last Modified: | 21 Oct 2021 07:32 |
| URI: | http://repository.ub.ac.id/id/eprint/167674 |
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