Pitaloka, Anggun (2018) Efek Ekstrak Etanol Jahe Merah (Zingiber Officinale Var. Rubrum) Terhadap Tebal Sel Otot Polos Tuba Falopi Pada Tikus Putih Strain Wistar Betina (Rattus Norvegicus). Sarjana thesis, Universitas Brawijaya.
Abstract
Salah satu gangguan kesehatan reproduksi yang terjadi pada usia subur adalah infertilitas. WHO memperkirakan sekitar 50-80 juta pasutri memiliki masalah infertilitas, dan setiap tahun muncul sekitar 2 juta pasangan infertil. Di Indonesia, pasangan infertil pada tahun 2013 mencapai 50 juta pasangan atau 15- 20% dari seluruh pasangan yang ada. Masalah yang sering kali muncul biasanya dikarenakan adanya hambatan kontraktilitas pada tuba falopi. Kontraksi otot polos ini dipengaruhi oleh tiga sistem intertitial yaitu hormon estrogen-progesteron, sistem adrenergik-non adrenergik dan prostaglandin. Sebagai zat antiprostaglandin, kandungan yang ada pada tanaman jahe diperkirakan dapat menyebabkan penipisan sel otot polos tuba falopi. Penelitian ini menggunakan tikus putih Rattus novergicus betina dengan usia 8-12 minggu dan berat 150-200 gram. Penelitian dilakukan di Laboratorium Farmakologi dan Patologi Anatomi FKUB. Penelitian dilakukan selama 3 siklus estrus yang terdiri dari 4 kelompok yaitu kelompok kontrol, perlakuan dosis 0.3 gram/KgBB (PI), perlakuan dosis 0.6 gr/KgBB (PII), dan perlakuan dosis 1.2 gram/KgBB (PIII). Pemberian ekstrak jahe merah dilakukan peroral dengan sonde selama 3 siklus estrus.Tikus dibedah pada fase estrus siklus estrus ke empat. Pengamatan ketebalan sel otot polos tuba falopi dilakukan oleh peneliti pada 4 titik. Hasil uji One Way ANOVA, rerata ketebalan otot polos tuba falopi (p= 0,456) pada kelompok yang diberi perlakuan dosis 1 (PI) dan dosis 2 (PII) memiliki kecenderungan penurunan meskipun tidak secara signifikan jika dibandingkan dengan kelompok kontrol. Namun pada kelompok perlakuan dosis 3 (PIII) tidak menunjukkan adanya penurunan ketebalan sel otot polos jika dibandingkan dengan kelompok kontrol. Hasil penelitian ini menunjukkan bahwa pemberian ekstrak jahe merah memiliki kecenderungan untuk menurunkan ketebalan sel otot polos tuba falopi meskipun tidak signifikan.
English Abstract
One of the reproductive health disorders that occur in child-bearing age is infertility. WHO estimates that about 50-80 million couples have infertility problems, and annually there are about 2 million infertile couples. In Indonesia, infertile couples in 2013 reach 50 million couples or 15-20% of all couples. Problems that often arise are usually due to the constraints of contractility in the fallopian tubes. Contraction of smooth muscle is influenced by three intertitial systems of estrogenprogesterone, adrenergic-non adrenergic and prostaglandin. As an antiprostaglandin substance, the content present in ginger plants is thought to lead to thinning of the smooth muscle cells of the fallopian tubes. This study used white rat Rattus novergicus female with age 8-12 weeks and weight 150-200 gram. The research was conducted in Pharmacology and Pathology-Anatomy Laboratory of FKUB. The experiment was conducted for 3 estrus cycles consisting of 4 groups: control group, treatment group with dose 0.3 gram/KgBB (PI), treatment group with dose 0.6 gr/KgBB (PII), and treatment group with dose 1.2 gram/KgBB (PIII ). The administration of red ginger extract was performed peroral with sonde for 3 estrous cycles. The rats were dissected at the estrous phase of the fourth estrus cycle. Observation of smooth muscle cell thickness of fallopian tubes was done by researchers at 4 points. One way ANOVA test result, mean thickness of tubal muscle of fallopian tube (p = 0,456) in group treated with dose 1 (PI) and dose 2 (PII) have decreasing trend although not significantly compared to control group. However, in the treatment group dose 3 (PIII) did not show a decrease in smooth muscle cell thickness when compared with the control group. The results of this study concluded that the administration of red ginger extract has a tendency to decrease the thickness of smooth muscle cells of fallopian tubes although not significant
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/192/051805433 |
| Uncontrolled Keywords: | infertil, tuba falopi, prostaglandin, jahe merah, infertile, fallopian tubes, prostaglandins, red ginger |
| Subjects: | 600 Technology (Applied sciences) > 615 Pharmacology and therapeutics > 615.3 Organics drugs > 615.32 Drugs derived from plants and mikroorganisms > 615.324 39 Drugs derived from specific plants (Ginger, Musaceae, Zingiberales) |
| Divisions: | Fakultas Kedokteran > Kebidanan |
| Depositing User: | Nur Cholis |
| Date Deposited: | 11 Jul 2019 03:51 |
| Last Modified: | 19 Oct 2021 07:34 |
| URI: | http://repository.ub.ac.id/id/eprint/167491 |
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