Sabillah, Jihan Izzati (2018) Analisis Cost-Effectiveness terhadap Penggunaan Antibiotik Empiris Sefuroksim dan Seftriakson pada Pasien Community- Acquired Pneumonia Dewasa di Ruang Rawat Inap RSUD Bangil. Sarjana thesis, Universitas Brawijaya.
Abstract
Pneumonia merupakan penyakit infeksi yang paling banyak terjadi di RSUD Bangil. Pilihan terapi lini pertama untuk pneumonia rawat inap di RSUD Bangil adalah sefuroksim dan seftriakson, dimana kedua antibiotik ini merupakan antibiotik yang sensitif terhadap bakteri penyebab pneumonia, dibanding antibiotik lainnya. Walaupun kedua antibiotik tersebut efektif untuk terapi pneumonia, namun cost-effective dari kedua antibiotik belum diketahui. Tujuan penelitian ini, untuk mengetahui antibiotik yang lebih cost-effective antara sefuroksim dan seftriakson, untuk terapi CAP di RSUD Bangil. Penelitian ini merupakan penelitian observasional analitik dengan metode pengumpulan data secara retrospektif, menggunakan perspektif penyedia layanan kesehatan. Sampel dipilih dengan teknik total sampling, dengan kriteria inklusi, pasien rawat inap usia 40-80 tahun di RSUD Bangil periode Januari-Desember 2017 dengan status pembayaran JKN. Sampel yang didapatkan sebanyak 26 pasien. Hasil ACER, menunjukkan antibiotik sefuroksim lebih hemat biaya dari segi lama respiration rate kembali normal, antibiotik seftriakson lebih hemat biaya dari segi lama rawat inap. Berdasarkan perhitungan ICER, diketahui bahwa diperlukan tambahan biaya Rp 159.750 bagi seftriakson untuk menghasilkan pengurangan 1 hari lama rawat inap, Rp 559.180. bagi sefuroksim untuk menghasilkan pengurangan 1 hari lama respiration rate kembali normal. Hasil uji komparatif terhadap lama rawat inap (p)=0.021, terhadap lama respiration rate kembali normal (p)=0.531. Hal ini menunjukkan adanya perbedaan signifikan berdasarkan lama rawat inap, dimana lama rawat inap pasien yang menggunakan sefuroksim lebih cepat dibanding pasien yang menggunakan seftriakson. Namun tidak ada perbedaan signifikan berdasarkan lama respiration rate kembali normal. Berdasarkan penelitian yang telah dilakukan, dapat disimpulkan bahwa seftriakson lebih cost-effective dibanding sefuroksim berdasarkan lama rawat inap.
English Abstract
Pneumonia is the most common infectious disease in RSUD Bangil. First-line therapy for pneumonia inpatient is cefuroxime and ceftriaxone, where both antibiotics are sensitive to treat pneumonia compared to others. Although both antibiotics are effective for pneumonia, but the cost-effectiveness is unknown. This study aims to determine the more cost-effective antibiotics between cefuroxime and ceftriaxone, for CAP therapy in RSUD Bangil. This study was an observational analytic study with retrospective data collection methods, using health care providers perspective. The samples were chosen by total sampling technique, with inclusion criteria, 40-80 years old inpatient at RSUD Bangil in January-December 2017 with JKN payment status. The sample was 26 patients. ACER results show that cefuroxime was more cost-effective in terms of respiration rates back to normal, ceftriaxone antibiotics was more cost-effective in terms of length of stay. Based on ICER, known that additional cost Rp 159,750 was needed for ceftriaxone to reduce 1 day of length of stay, Rp 559,180 was needed for sefuroxime to reduce 1 day of respiration rate back to normal. Comparative test result on length of stay (p) = 0.021, on duration respiration rate back to normal (p) = 0.531. This suggests significant difference based on length of stay, where the length of stay of patients using cefuroxime is faster than ceftriaxone. However, there was no significant difference based on duration of respiration rate back to normal. Based on the research, it can be concluded that ceftriaxone is more cost-effective than cefuroxime based on length of stay.
| Item Type: | Thesis (Sarjana) |
|---|---|
| Identification Number: | SKR/FK/2018/318/051808216 |
| Uncontrolled Keywords: | sefuroksim, seftriakson, analisis cost-effectiveness, pneumonia-cefuroxime, ceftriaxone, cost-effectiveness analysis, pneumonia |
| Subjects: | 600 Technology (Applied sciences) > 616 Diseases > 616.2 Diseases of respiratory system |
| Divisions: | Fakultas Kedokteran > Farmasi |
| Depositing User: | soegeng sugeng |
| Date Deposited: | 05 Nov 2019 07:31 |
| Last Modified: | 21 Oct 2021 07:49 |
| URI: | http://repository.ub.ac.id/id/eprint/167467 |
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